Base excision repair pathways of bacteria: New promise for an old problem
Abstract
Infectious diseases continue to be a major cause of human mortality. With the emergence of drug resistance, diseases that were long thought to have been curable by antibiotics are resurging. There is an urgent clinical need for newer antibiotics that target novel cellular pathways to overcome resistance to currently used therapeutics. The base excision repair (BER) pathways of the pathogen restore altered bases and safeguard the genomic integrity of the pathogen from the host's immune response. Although the BER machinery is of paramount importance to the survival of the pathogens, its potential as a drug target is largely unexplored. In this review, we discuss the importance of BER in different pathogenic organisms and the potential of its inhibition with small molecules.
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Both prokaryotes and eukaryotes utilize homologous proteins with similar function for efficient repair.
“Both prokaryotes and eukaryotes utilize homologous proteins with similar function for efficient repair.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [110]
Eukaryotes possess several additional enzymes for BER.
“However, eukaryotes possess several additional enzymes [110].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [110]
BER is a highly conservative pathway responsible for repair of damage arising during alkylation, deamination, and oxidation of DNA bases.
“Base excision repair is highly conservative pathway responsible for the repair of damage that arise during alkylation, deamination, and oxidation of DNA bases.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [110]
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1 of the 119 references couldn’t be matched to a known paper.
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Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies
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Functional Characterization of Uracil-DNA Glycosylase from Staphylococcus aureus
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- Authors
- Kurthkoti, K., Kumar, P., Sang, P. B., & Varshney, U.
- Affiliations
- Rajiv Gandhi Centre for Biotechnology (IN)
- Rutgers, The State University of New Jersey (US)
- Indian Institute of Science Bangalore (IN)
- Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2020-02
- Volume
- 12
- Issue
- 4
- Pages
- 339-355
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- OpenAlex
- W3004520234
- Cited by
- 12
- References
- 119
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Future Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- NOT FOUND REPOSITORY (Indian Institute of Science Bangalore) (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- base excision repair, bacterial DNA repair, drug resistance, antibiotic targets, small molecule inhibitors, pathogenic bacteria, genome stability, novel antibiotics
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Communicable Diseases, DNA Damage, DNA Repair, Humans, Microbial Sensitivity Tests, Drug Resistance, Bacterial, Small Molecule Libraries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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