Cited by 12DNA Repair MechanismsBacterial Genetics and BiotechnologyBiochemical and Molecular Research

Base excision repair pathways of bacteria: New promise for an old problem

Kurthkoti, Krishna, Kumar, Pradeep, Sang, Pau Biak, Varshney, Umesh·2020·Future Medicinal Chemistry

Abstract

Infectious diseases continue to be a major cause of human mortality. With the emergence of drug resistance, diseases that were long thought to have been curable by antibiotics are resurging. There is an urgent clinical need for newer antibiotics that target novel cellular pathways to overcome resistance to currently used therapeutics. The base excision repair (BER) pathways of the pathogen restore altered bases and safeguard the genomic integrity of the pathogen from the host's immune response. Although the BER machinery is of paramount importance to the survival of the pathogens, its potential as a drug target is largely unexplored. In this review, we discuss the importance of BER in different pathogenic organisms and the potential of its inhibition with small molecules.

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Crossref · 10.4155/fmc-2019-0267

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118 of 118 references verified0 citation errors · 0 not checkable

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Authors
Kurthkoti, K., Kumar, P., Sang, P. B., & Varshney, U.
Affiliations
  • Rajiv Gandhi Centre for Biotechnology (IN)
  • Rutgers, The State University of New Jersey (US)
  • Indian Institute of Science Bangalore (IN)
  • Jawaharlal Nehru Centre for Advanced Scientific Research (IN)
Venue
Future Medicinal Chemistry
Published
2020-02
Volume
12
Issue
4
Pages
339-355
ISSN
  • 1756-8919 (ISSN-L)
  • 1756-8927
OpenAlex
W3004520234
Cited by
12
References
119
Citations by year
2026: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1
FWCI
0.19
Type
journal article
Language
en
Open access
closed
Locations
  • Future Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • NOT FOUND REPOSITORY (Indian Institute of Science Bangalore) (acceptedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords
base excision repair, bacterial DNA repair, drug resistance, antibiotic targets, small molecule inhibitors, pathogenic bacteria, genome stability, novel antibiotics
MeSH terms
Anti-Bacterial Agents, Bacteria, Communicable Diseases, DNA Damage, DNA Repair, Humans, Microbial Sensitivity Tests, Drug Resistance, Bacterial, Small Molecule Libraries

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