The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
The chemical repertoire of natural ribozymes
Abstract
Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity--they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages of life on Earth.
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“Today, RNA serves as the sole genetic molecule in many viruses, and the number of reactions catalyzed by RNA enzymes (“ribozymes”) is ever increasing (Doudna and Cech, 2002; Chen et al., 2007).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Doudna and Cech, 2002
In the citing paper
“Today, RNA serves as the sole genetic molecule in many viruses, and the number of reactions catalyzed by RNA enzymes (“ribozymes”) is ever increasing (Doudna and Cech, 2002; Chen et al., 2007).”
From The Astrobiology Primer v2.0 (2016) · cites this paper as Doudna and Cech, 2002
Citations
Cites
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
Ban, N., Nissen, P., Hansen, J., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.905 · Cited by 3,327
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684
Kruger, K., Grabowski, P. J., Zaug, A. J., Sands, J., Gottschling, D. E., & Cech, T. R. (1982) · Cell · doi:10.1016/0092-8674(82)90414-7 · Cited by 2,331
Self-citationThe Structural Basis of Ribosome Activity in Peptide Bond Synthesis
Nissen, P., Hansen, J., Ban, N., Moore, P. B., & Steitz, T. A. (2000) · Science · doi:10.1126/science.289.5481.920 · Cited by 2,269
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
Cate, J. H. D., Gooding, A. R., Podell, E. R., Zhou, K., Golden, B. L., Kundrot, C. E., Cech, T. R., & Doudna, J. A. (1996) · Science · doi:10.1126/science.273.5282.1678 · Cited by 1,249
Self-citationMichel, F., & Westhof, É. (1990) · Journal of Molecular Biology · doi:10.1016/0022-2836(90)90386-z · Cited by 1,239
In Vitro Selection of Functional Nucleic Acids
Wilson, D. S., & Szostak, J. W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.611 · Cited by 1,217
Three-dimensional structure of a hammerhead ribozyme
Pley, H. W., Flaherty, K. M., & McKay, D. (1994) · Nature · doi:10.1038/372068a0 · Cited by 946
Reversible Unfolding of Single RNA Molecules by Mechanical Force
Liphardt, J., Onoa, B., Smith, S. B., Tinoco, I., & Bustamante, C. (2001) · Science · doi:10.1126/science.1058498 · Cited by 931
Crystal structure of a hepatitis delta virus ribozyme
Ferré-D’Amaré, A. R., Zhou, K., & Doudna, J. A. (1998) · Nature · doi:10.1038/26912 · Cited by 790
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Functional Nucleic Acid Sensors
Liu, J., Cao, Z. C., & Lu, Y. (2009) · Chemical Reviews · doi:10.1021/cr030183i · Cited by 2,188
RNAstructure: software for RNA secondary structure prediction and analysis
Reuter, J. S., & Mathews, D. H. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-129 · Cited by 2,018
Synthetic biology: applications come of age
Khalil, A. S., & Collins, J. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2775 · Cited by 1,413
Rauch, F., & Glorieux, F. H. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16051-0 · Cited by 1,202
Biologically Active Molecules with a “Light Switch”
Mayer, G., & Heckel, A. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600387 · Cited by 1,113
Metadata
- Authors
- Doudna, J. A., & Cech, T. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Nature
- Published
- 2002-07
- Volume
- 418
- Issue
- 6894
- Pages
- 222-228
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1980410097
- Cited by
- 745
- References
- 99
- Citations by year
- 2026: 28 · 2025: 21 · 2024: 25 · 2023: 14 · 2022: 23 · 2021: 24 · 2020: 24 · 2019: 29 · 2018: 15 · 2017: 29 · 2016: 17 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 26
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- ribozymes, RNA catalysis, RNA chemistry, origin of life, RNA evolution, phosphodiester bond cleavage
- MeSH terms
- Animals, Catalysis, Endoribonucleases, Humans, Introns, Models, Molecular, Nucleic Acid Conformation, Ribonucleoproteins, RNA Splicing, Substrate Specificity, RNA, Catalytic, Ribonuclease P
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