Doudna, Jennifer A.

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 17,116

The new frontier of genome engineering with CRISPR-Cas9

Doudna, J. A., & Charpentier, E. (2014) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 7,062

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

Qi, L. S., Larson, M. H., Gilbert, L. A., Doudna, J. A., Weissman, J. S., Arkin, A. P., & Lim, W. A. (2013) · Cell

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 5,016

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Chen, J. S., Ma, E., Harrington, L. B., Da Costa, M., Tian, X., Palefsky, J. M., & Doudna, J. A. (2018) · Science

CRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniques

Cited by 4,507

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

Gilbert, L. A., Larson, M. H., Morsut, L., Liu, Z., Brar, G. A., Torres, S. E., Stern-Ginossar, N., Brandman, O., Whitehead, E. H., Doudna, J. A., et al. (2013) · Cell

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 3,696

RNA-programmed genome editing in human cells

Jinek, M., East, A., Cheng, A., Lin, S., Ma, E., & Doudna, J. (2013) · eLife

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,098

CRISPR–Cas9 Structures and Mechanisms

Jiang, F., & Doudna, J. A. (2017) · Annual Review of Biophysics

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,029

RNA-guided genetic silencing systems in bacteria and archaea

Wiedenheft, B., Sternberg, S. H., & Doudna, J. A. (2012) · Nature

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 1,851

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

Pattanayak, V., Lin, S., Guilinger, J. P., Ma, E., Doudna, J. A., & Liu, D. R. (2013) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,487

CRISPR-Cas guides the future of genetic engineering

Knott, G. J., & Doudna, J. A. (2018) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,410

Structures of Cas9 endonucleases reveal RNA-mediated conformational activation

Jinek, M., Jiang, F., Taylor, D. W., Sternberg, S. H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., et al. (2014) · Science

CRISPR and Genetic EngineeringEnzyme Structure and Function

Cited by 1,230

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

Lin, S., Staahl, B. T., Alla, R. K., & Doudna, J. A. (2014) · eLife

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,189

Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

Chen, J. S., Dagdas, Y. S., Kleinstiver, B. P., Welch, M. M., Sousa, A. A., Harrington, L. B., Sternberg, S. H., Joung, J. K., Yildiz, A., & Doudna, J. A. (2017) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,168

The promise and challenge of therapeutic genome editing

Doudna, J. A. (2020) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,126

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Richter, M. F., Zhao, K. T., Eton, E., Lapinaite, A., Newby, G. A., Thuronyi, B. W., Wilson, C., Koblan, L. W., Zeng, J., Bauer, D. E., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,020

Applications of CRISPR technologies in research and beyond

Barrangou, R., & Doudna, J. A. (2016) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,005

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

Lee, K., Conboy, M., Park, H. M., Jiang, F., Kim, H. J., Dewitt, M. A., Mackley, V. A., Chang, K., Rao, A., Skinner, C., et al. (2017) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 755

The chemical repertoire of natural ribozymes

Doudna, J. A., & Cech, T. R. (2002) · Nature

RNA and protein synthesis mechanismsOrigins and Evolution of Life

Cited by 745

A prudent path forward for genomic engineering and germline gene modification

Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R. A., Church, G., Corn, J. E., Daley, G. Q., Doudna, J. A., Fenner, M., et al. (2015) · Science

CRISPR and Genetic EngineeringBiomedical Ethics and Regulation

Cited by 733

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

Schumann, K., Lin, S., Boyer, E., Simeonov, D. R., Subramaniam, M., Gate, R. E., Haliburton, G. E., Ye, C. J., Bluestone, J. A., Doudna, J. A., et al. (2015) · Proceedings of the National Academy of Sciences

CRISPR and Genetic EngineeringCAR-T cell therapy research

Cited by 702

Conformational control of DNA target cleavage by CRISPR–Cas9

Sternberg, S. H., LaFrance, B., Kaplan, M., & Doudna, J. A. (2015) · Nature

CRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry

Cited by 627

CasX enzymes comprise a distinct family of RNA-guided genome editors

Liu, J.-J., Orlova, N., Oakes, B. L., Ma, E., Spinner, H. B., Baney, K. L. M., Chuck, J., Tan, D., Knott, G. J., Harrington, L. B., et al. (2019) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 446

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes

Staahl, B. T., Benekareddy, M., Coulon-Bainier, C., Banfal, A. A., Floor, S. N., Sabo, J. K., Urnes, C., Munares, G. A., Ghosh, A., & Doudna, J. A. (2017) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 355

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

Dagdas, Y. S., Chen, J. S., Sternberg, S. H., Doudna, J. A., & Yildiz, A. (2017) · Science Advances

CRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry

Cited by 293