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The chemical repertoire of natural ribozymes

Doudna, Jennifer A., Cech, Thomas R.·2002·Nature

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Abstract

Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity--they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages of life on Earth.

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Authors: Doudna, J. A., & Cech, T. R.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Doudna, Jennifer A.
Cech, Thomas R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-07
Volume: 418
Issue: 6894
Pages: 222-228
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/418222a
OpenAlex: W1980410097
Cited by: 745
References: 99
Citations by year: 2026: 28 · 2025: 21 · 2024: 25 · 2023: 14 · 2022: 23 · 2021: 24 · 2020: 24 · 2019: 29 · 2018: 15 · 2017: 29 · 2016: 17 · 2015: 22 · 2014: 18 · 2013: 26 · 2012: 26
FWCI: 3.90
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: ribozymes, RNA catalysis, RNA chemistry, origin of life, RNA evolution, phosphodiester bond cleavage
MeSH terms: Animals, Catalysis, Endoribonucleases, Humans, Introns, Models, Molecular, Nucleic Acid Conformation, Ribonucleoproteins, RNA Splicing, Substrate Specificity, RNA, Catalytic, Ribonuclease P

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The chemical repertoire of natural ribozymes

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