Cech, Thomas R.

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

Cech, T. R., & Steitz, J. A. (2014) · Cell

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 2,524

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena

Kruger, K., Grabowski, P. J., Zaug, A. J., Sands, J., Gottschling, D. E., & Cech, T. R. (1982) · Cell

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 2,331

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,256

Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase

Lingner, J., Hughes, T. R., Shevchenko, A., Mann, M., Lundblad, V., & Cech, T. R. (1997) · Science

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,269

Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans

Baumann, P., & Cech, T. R. (2001) · Science

Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid Chemistry

Cited by 1,028

The chemical repertoire of natural ribozymes

Doudna, J. A., & Cech, T. R. (2002) · Nature

RNA and protein synthesis mechanismsOrigins and Evolution of Life

Cited by 745

The POT1-TPP1 telomere complex is a telomerase processivity factor.

Wang, F., Podell, E. R., Zaug, A. J., Yang, Y., Baciu, P., Cech, T. R., & Lei, M. (2007) · Nature

Telomeres, Telomerase, and SenescenceDNA and Nucleic Acid Chemistry

Cited by 704

The Ribosome Is a Ribozyme

Cech, T. R. (2000) · Science

RNA and protein synthesis mechanismsOrigins and Evolution of Life

Cited by 382

Telomerase and the maintenance of chromosome ends

Bryan, T. M., & Cech, T. R. (1999) · Current Opinion in Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 301

Peptide bond formation by in vitro selected ribozymes

Zhang, B., & Cech, T. R. (1997) · Nature

RNA and protein synthesis mechanismsOrigins and Evolution of Life

Cited by 299

TERT promoter mutations and telomerase reactivation in urothelial cancer

Borah, S., Xi, L., Zaug, A. J., Powell, N. M., Dancik, G. M., Cohen, S. B., Costello, J. C., Theodorescu, D., & Cech, T. R. (2015) · Science

Telomeres, Telomerase, and SenescenceBladder and Urothelial Cancer Treatments

Cited by 292

The RNA Worlds in Context

Cech, T. R. (2012) · Cold Spring Harbor Perspectives in Biology

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 244

In vitro splicing of the ribosomal RNA precursor in nuclei of tetrahymena

Zaug, A. J., & Cech, T. R. (1980) · Cell

RNA Research and SplicingNuclear Structure and Function

Cited by 115

The structure of human CST reveals a decameric assembly bound to telomeric DNA

Lim, C. J., Barbour, A. T., Zaug, A. J., Goodrich, K. J., McKay, A. E., Wuttke, D. S., & Cech, T. R. (2020) · Science

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 111

Structural basis for inactivation of PRC2 by G-quadruplex RNA

Song, J., Gooding, A. R., Hemphill, W. O., Kasinath, V., & Cech, T. R. (2023) · Science

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 73

Structural basis for inactivation of PRC2 by G-quadruplex RNA

Song, J., Gooding, A. R., Hemphill, W. O., Love, B. D., Robertson, A., Yao, L., Zon, L. I., North, T. E., Kasinath, V., & Cech, T. R. (2023) · Science

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 73

Toward predicting self-splicing and protein-facilitated splicing of group I introns

Vicens, Q., Paukstelis, P. J., Westhof, E., Lambowitz, A. M., & Cech, T. R. (2008) · RNA

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 49

A natural ribozyme with 3’,5’ RNA ligase activity

Vicens, Q., & Cech, T. R. (2009) · Nature Chemical Biology

RNA and protein synthesis mechanismsOrigins and Evolution of Life

Cited by 37