The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.
Abstract
Mutations of mitochondrial DNA (mtDNA) cause several well-recognized human genetic syndromes with deficient oxidative phosphorylation and may also have a role in ageing and acquired diseases of old age. We report here that hallmarks of mtDNA mutation disorders can be reproduced in the mouse using a conditional mutation strategy to manipulate the expression of the gene encoding mitochondrial transcription factor A (Tfam, previously named mtTFA), which regulates transcription and replication of mtDNA. Using a loxP-flanked Tfam allele (TfamloxP) in combination with a cre-recombinase transgene under control of the muscle creatinine kinase promoter, we have disrupted Tfam in heart and muscle. Mutant animals develop a mosaic cardiac-specific progressive respiratory chain deficiency, dilated cardiomyopathy, atrioventricular heart conduction blocks and die at 2-4 weeks of age. This animal model reproduces biochemical, morphological and physiological features of the dilated cardiomyopathy of Kearns-Sayre syndrome. Furthermore, our findings provide genetic evidence that the respiratory chain is critical for normal heart function.
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In the citing paper
“Loss of Tfam causes depletion of mtDNA, loss of mitochondrial transcripts, loss of mtDNA-encoded polypeptides, and severe respiratory chain deficiency (8)(9)(10)(11)(12).”
From Increased mitochondrial mass in mitochondrial myopathy mice (2002) · cites this paper as [9]
In the citing paper
“Mice with the genotype Tfam loxP ͞Tfam loxP , hereafter referred to as ''control mice,'' were used as controls and have been shown previously to have normal Tfam expression, normal mtDNA copy number, and normal respiratory chain function in different tissues (9).”
From Increased mitochondrial mass in mitochondrial myopathy mice (2002) · cites this paper as [9]
In the citing paper
“We have studied a variety of mouse models with decreased mtDNA expression (10, 12–18) and such mice have increased cell death with little or no increase of oxidative stress (18, 30).”
From Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons (2007) · cites this paper as [13]
In the citing paper
“Skeletal muscle-specific Tfam deficiency is accompanied by increased AMP kinase activation and increased glycolysis, indicating that compensatory mechanisms to maintain ATP levels are activated in response to impaired mitochondrial energetics (282).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [282]
In the citing paper
“Similarly, skeletal and cardiac muscle-specific deletion of Tfam causes severe OXPHOS deficits, dilated cardiomyopathy, and death during early postnatal life (282).”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [282]
In the citing paper
“In these mice, insulin sensitivity is normal and glucose tolerance is enhanced, consistent with a need for enhanced fuel utilization in response to inefficient mitochondrial ATP production.”
From The role of mitochondria in the pathogenesis of type 2 diabetes (2010) · cites this paper as [282]
Citations
Cites
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
Larsson, N.-G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G. S., & Clayton, D. A. (1998) · Nature Genetics · doi:10.1038/ng0398-231 · Cited by 1,594
Self-citationBiochemical and molecular investigations in respiratory chain deficiencies
Rustin, P., Chrétien, D., Bourgeron, T., Gérard, B., Rötig, A., Saudubray, J., & Münnich, A. (1994) · Clinica Chimica Acta · doi:10.1016/0009-8981(94)90055-8 · Cited by 1,265
Self-citationMitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?
Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,262
Replication And Transcription Of Vertebrate Mitochondrial Dna
Clayton, D. A. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.002321 · Cited by 652
Self-citationGraham, B. H., Waymire, K. G., Cottrell, B. A., Trounce, I. A., MacGregor, G. R., & Wallace, D. C. (1997) · Nature Genetics · doi:10.1038/ng0797-226 · Cited by 556
Hayashi, J., Ohta, S., Kikuchi, A., Takemitsu, M., Goto, Y., & Nonaka, I. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10614 · Cited by 553
Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins
Parisi, M. A., & Clayton, D. A. (1991) · Science · doi:10.1126/science.2035027 · Cited by 548
Self-citationMOLECULAR GENETIC ASPECTS OF HUMAN MITOCHONDRIAL DISORDERS
Larsson, N.-G., & Clayton, D. A. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.001055 · Cited by 493
Self-citationMammalian mitochondrial genetics: heredity, heteroplasmy and disease
Lightowlers, R. N., Chinnery, P. F., Turnbull, D. M., & Howell, N. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01266-3 · Cited by 469
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Items 301–400 of 433
Estrés oxidativo mitocondrial y envejecimiento cardíaco
Martín‐Fernández, B., & Gredilla, R. (2018) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2017.12.002 · Cited by 12
Skeletal phenotypes and molecular mechanisms in aging mice
Guan, Q., 上海体育大学运动健康学院, 上. 2., Zhang, Y., Wang, Z., Liu, X.-H., Zou, J., & Zhang, L.-L. (2024) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2023.397 · Cited by 13
Szalárdy, L., Molnar, M. F., Maszlag-Török, R., Zádori, D., Kovács, G. G., Vécsei, L., & Klivènyi, P. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.021 · Cited by 10
Mitochondrial oxidative stress and cardiac ageing
Martín‐Fernández, B., & Gredilla, R. (2018) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2017.12.002 · Cited by 10
Tissue-Specific Knockout Model for Study of Mitochondrial DNA Mutation Disorders
Trifunović, A., & Larsson, N. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)53065-2 · Cited by 10
Self-citationZhu, W., Lepore, J. J., Saba, S., JOSEPH, S., Link, M. S., Homoud, M. K., Estes, N. A. M., Wang, P. J., & Leiden, J. M. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2003.02002.x · Cited by 10
Hood, D. A., & Hood, D. A. (2013) · Cited by 10
Ishikawa, K., & Nakada, K. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129835 · Cited by 9
Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model
Nakada, K., Sato, A., & Hayashi, J. (2008) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.84.155 · Cited by 9
Mechanistic aspects of mammalian cell size control
Yamamoto, K., & Mak, T. W. (2016) · Development Growth & Differentiation · doi:10.1111/dgd.12334 · Cited by 10
The Direct Tri-Iodothyronine Mitochondrial Pathway: Science Or Mythology?
Wrutniak‐Cabello, C., Casas, F., & Cabello, G. (2000) · Thyroid · doi:10.1089/thy.2000.10.965 · Cited by 9
Liu, Y., Zhao, Y., Tang, R., Jiang, X., Wang, Y., & Gu, T. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11593 · Cited by 8
Nakada, K., Ono, T., & Hayashi, J. (2002) · Mitochondrion · doi:10.1016/s1567-7249(02)00007-7 · Cited by 8
Mitochondrial Gene Expression in Diabetes Mellitus: Effect of Nutrition
Berdanier, C. D. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2001.tb06990.x · Cited by 8
Cardiología pediátrica en la era de la genómica
Marı́n-Garcı́a, J. (2004) · Revista Española de Cardiología · doi:10.1016/s0300-8932(04)77112-2 · Cited by 8
Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion
Hu, S., Tang, X., Zhu, F., Chen, L., Wang, S., Wang, H., Li, P., & Li, Y. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101282 · Cited by 7
Heiat, F., Ahmadi, A., & Shojaeifard, M. B. (2023) · BioMed Research International · doi:10.1155/2023/3631458 · Cited by 8
Au, H., Yeh, T., Kao, S., Shih, C.-M., Hsieh, R., & Tzeng, C. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.03.072 · Cited by 7
Butyrate extends health and lifespan in mice with mitochondrial deficiency
Gabandé‐Rodríguez, E., Heras, M. M. G. D. L., de Erenchun, P. R.-R., Simó, C., García‐Cañas, V., Inohara, N., Berenguer, I., Enriquez-Zarralanga, V., Fernández-Almeida, Á., Oller, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70547-4 · Cited by 7
Preimplantation death of xenomitochondrial mouse embryo harbouring bovine mitochondria
Kawahara, M., Koyama, S., Iimura, S., Yamazaki, W., Tanaka, A., Kohri, N., Sasaki, K., & Takahashi, M. (2015) · Scientific Reports · doi:10.1038/srep14512 · Cited by 6
New Roles of Mitochondrial Transcription Factor A in Cancer
Yoshida, Y., & Hoshino, S. (2012) · Journal of Physical Chemistry & Biophysics · doi:10.4172/2161-0398.1000101 · Cited by 6
Ziemann, M., Wu, W., Deng, X., & Du, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.921610 · Cited by 6
[Genetics and molecular biology of the congenital, and acquired heart disease].
Cruz‐Robles, D., de la Peña-Dı́az, A., Arce-Fonseca, M., Trejo, J. D. J. G., Mendez, O., & Vargas‐Alarcón, G. (2005) · PubMed · Cited by 6
Mitochondrial Disorders: Nuclear Gene Mutations
Ghezzi, D., & Zeviani, M. (2011) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0005540.pub2 · Cited by 6
Boräng, S., Andersson, T., Thelin, A., Odeberg, J., & Lundeberg, J. (2004) · Pathobiology · doi:10.1159/000074426 · Cited by 5
Development of Animal Models of Drug‐Induced Mitochondrial Toxicity
Boelsterli, U. A., & Lee, Y. H. (2008) · doi:10.1002/9780470372531.ch23 · Cited by 5
Yu, T., Gao, Q., Zhang, G., Li, T., Liu, X., Li, C., Zheng, L., Sun, X., Wu, J., Cao, H., et al. (2024) · Frontiers of Medicine · doi:10.1007/s11684-024-1065-7 · Cited by 4
Tamashiro, H., Ishikawa, K., Sadotomo, K., Ogasawara, E., & Nakada, K. (2025) · Aging Cell · doi:10.1111/acel.70085 · Cited by 4
Targeted Mitochondrial Genome Elimination
Bacman, S. R., Pereira, C. V., & Moraes, C. T. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_24 · Cited by 4
Marı́n-Garcı́a, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00012-3 · Cited by 4
An experimental approach to study the function of mitochondria in cardiomyopathy
Chung, Y. W., & Kang, S. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.10.153 · Cited by 4
Human mitochondrial transcription and translation
Fontanesi, F., Tigano, M., Fu, Y., Sfeir, A. J., & Barrientos, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819656-4.00002-4 · Cited by 5
Illuminating mitochondrial translation through mouse models
Hughes, L. A., Rackham, O., & Filipovska, A. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae020 · Cited by 4
Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function
Kelly, D. P., & Scarpulla, R. C. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381510-1.00016-8 · Cited by 4
Mitochondrial Disease: Maintenance of Mitochondrial Genome and Molecular Diagnostics
Kang, D., & Hamasaki, N. (2006) · Advances in clinical chemistry · doi:10.1016/s0065-2423(06)42006-0 · Cited by 4
Mitochondrial Calcium Signalling: Role in Oxidative Phosphorylation Diseases
Oulès, B., Prete, D., & Mouni, C. (2012) · InTech eBooks · doi:10.5772/32117 · Cited by 4
Shimizu, A., Enoki, S., Ishikawa, K., Mito, T., Obata, K., Nagashima, R., Yonekawa, H., Nakada, K., & Hayashi, J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.072 · Cited by 4
Mitochondrial encephalomyopathy
Goto, Y. (2000) · Neuropathology · doi:10.1046/j.1440-1789.2000.00304.x · Cited by 4
Mitochondrial DNA depletion syndrome and its cardiac complication
Bao, S., Ye, J., Zhou, J., Chen, Z., Xu, Y., & Sun, C. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1582219 · Cited by 3
Heart Mitochondria: A Receiver and Integrator of Signals
Marı́n-Garcı́a, J. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9461-5_8 · Cited by 3
Retracted: Mitochondria, the missing link between body and soul: Proteomic prospective evidence
Warda, M., & Han, J. (2008) · PROTEOMICS · doi:10.1002/pmic.200700695 · Cited by 3
RetractedGENE KICKED MOUSE: KNOCK OUT MOUSE AND ITS APPLICATION
Rajashekar, B., Suhasini, K., & Pattar, J. (2013) · International Research Journal of Pharmacy · doi:10.7897/2230-8407.04703 · Cited by 3
Pediatric Cardiology in the Genomic Era
Marı́n-Garcı́a, J. (2004) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(06)60158-8 · Cited by 3
Gozalo, A. S., Zerfas, P. M., Elkins, W. R., & Gieseck, R. L. (2020) · Comparative Medicine · doi:10.30802/aalas-cm-19-000059 · Cited by 3
Mitochondria in Diabetes Mellitus
Lee, H. K. (2005) · Oxidative stress and disease · doi:10.1201/9781420028843.ch8 · Cited by 3
Genética y medicina molecular en cardiología
Rojas‐Martínez, A., Ortíz-López, R., & Delgado‐Enciso, I. (2001) · Revista Española de Cardiología · doi:10.1016/s0300-8932(01)76268-9 · Cited by 3
Conway, R. M., Cursiefen, C., Behrens, J., Naumann, G. O. H., & Holbach, L. (2003) · Ophthalmologica · doi:10.1159/000068239 · Cited by 3
Жейкова, Т. В., Golubenko, M. V., Буйкин, С. В., Makeeva, O. A., Александрович, Л. А., Цимбалюк, И. В., Shipulin, V. V., & Puzyryov, V. P. (2012) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2012-6-47-50 · Cited by 2
Modeling Mitochondrial Dysfunction in Neurodegenerative Disease
Komen, J. C., & Thorburn, D. R. (2011) · Springer eBooks · doi:10.1007/978-0-85729-701-3_12 · Cited by 2
Conservation in mitochondrial DNA: Parallelized estimation and alignment influence
Merino-Casallo, F., Álvarez-Jarreta, J., & Mayordomo, E. (2015) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm.2015.7359887 · Cited by 2
Generating Mouse Models of Mitochondrial Disease
Ylikallio, E., & Tyynismaa, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405195-9.00043-3 · Cited by 2
Wilson, T. J., Lazner, F., Kola, I., & Hertzog, P. J. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4657-3_5 · Cited by 2
Reactive Oxygen Species in Mitochondrial Encephalomyopathy: Mechanisms and Effects
Park, S. Y., & Haller, R. G. (2010) · Humana Press eBooks · doi:10.1007/978-1-60327-514-9_15 · Cited by 2
Rumyantseva, A., Tippetts, T. S., Wilhalm, A., Carter, W., Moedas, M. F., Rosenberger, F. A., Moore, D., Végvári, Á., Hinze, Y., Muellner-Wong, L., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeg8792 · Cited by 3
Animal Models of OXPHOS Disorders
Hance, N., & Larsson, N. (2007) · Springer eBooks · doi:10.1007/0-387-26992-4_9 · Cited by 1
Self-citationAn Introduction to Mitochondria and the Heart
Marı́n-Garcı́a, J. (2005) · Developments in cardiovascular medicine · doi:10.1007/0-387-25575-3_1 · Cited by 1
Animal Models of Mitochondrial Diseases Associated with Nuclear Gene Mutations
Averina, O. A., Kuznetsova, S. A., Permyakov, O. A., & Владимирович, С. П. (2024) · Acta Naturae · doi:10.32607/actanaturae.25442 · Cited by 2
Cardiomyopathy and Heart Failure in Aging
Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_7 · Cited by 2
Marı́n-Garcı́a, J. (2007) · Elsevier eBooks · doi:10.1016/b978-012373698-7/50013-9 · Cited by 1
Thyroid Hormone and Myocardial Mitochondria
Marín-García, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_22 · Cited by 2
Targeting the Mitochondria in Cardiovascular Diseases
Marı́n-Garcı́a, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_23 · Cited by 1
Marı́n-Garcı́a, J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-147-9_7 · Cited by 1
Mouse Models of Receptor Tyrosine Kinases
Holcmann, M., Amberg, N., Drobits, B., Glitzner, E., Komposch, K., Robson, J., Savarese, F., Srivatsa, S., Stulnig, G., & Sibilia, M. C. (2014) · Springer eBooks · doi:10.1007/978-1-4939-2053-2_11 · Cited by 1
Fatty Acid and Glucose Metabolism in Cardiac Disease
Marín-García, J. (2007) · Elsevier eBooks · doi:10.1016/b978-012373698-7/50016-4 · Cited by 1
Diabetic conditions induce intolerance to accumulation of pathogenic mitochondrial DNAsPreprint
Ogasawara, E., Katada, S., Mito, T., Hayashi, J., & Nakada, K. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/790956 · Cited by 2
Hong, Y. S., Longchamps, R. J., Zhao, D., Castellani, C. A., Loehr, L. R., Chang, P. P., Matsushita, K., Grove, M. L., Boerwinkle, E., Arking, D. E., et al. (2019) · medRxiv · doi:10.1101/19012013 · Cited by 1
Models of Cardiac Disease in the Mouse
Ikeda, Y., & Ross, J. (2001) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-1653-8_21 · Cited by 1
Fatty Acid and Glucose Metabolism in Cardiac Disease
Marı́n-Garcı́a, J. (2005) · Developments in cardiovascular medicine · doi:10.1007/0-387-25575-3_7 · Cited by 1
Atrioventricular Conduction Disturbances
Bergfeldt, L. (1999) · Cardiac Electrophysiology Review · doi:10.1023/a:1009992822507 · Cited by 1
Jongbloed, R. J. E., van den Bosch, B. J. C., de Coo, I. F. M., & Smeets, H. J. M. (2001) · Developments in cardiovascular medicine · doi:10.1007/978-94-010-1019-1_11 · Cited by 1
Das Herz bei primären Muskelkrankheiten
Feiden, W. (2000) · Spezielle pathologische Anatomie · doi:10.1007/978-3-642-56944-9_14 · Cited by 1
MittoSAM-dependent lipoylation controls postnatal heart development via metabolic remodelingPreprint
Rumyantseva, A., Wilhalm, A., Carter, W., Tippetts, T. S., Moedas, M., Rosenberger, F., Moore, D., Végvári, Á., Hinze, Y., Muellner-Wong, L. S., et al. (2026) · bioRxiv · doi:10.64898/2026.04.20.719537 · Cited by 1
Bioenergetics and Metabolic Changes in the Failing Heart
Marı́n-Garcı́a, J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-147-9_4
Patho-genetic characterization of the muscular dystrophy gene myotilin
Garvey, S. M. (2007) · DukeSpace (Duke University)
The Role of Schwann Cell Mitochondrial Metabolism in Schwann Cell Biology and Axonal Survival
Viader, A. (2011) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7319sxj
Indrieri, A. (2010) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/8451
Bauer, B. S. (2008) · University Library - University of Saskatchewan (University of Saskatchewan)
Mitochondrial dysfunction in neurodegeneration
Ekstrand, M. I. (2005) · Figshare
Mechanism and Regulation of Mitochondrial Transcription in Animal Cells
Polosa, P. L., Roberti, M., & Cantatore, P. (2011) · Springer eBooks · doi:10.1007/978-3-642-22380-8_11
Vitamin A and Mitochondrial Gene Expression
Everts, H. B., & Berdanier, C. D. (2001) · CRC Press eBooks · doi:10.1201/9781420039108-14
Chapter 6 Pathophysiology of Mitochondrial Disease as Illuminated by Animal Models
Wallace, D. (2002) · Blue books of practical neurology · doi:10.1016/s1877-3419(09)70065-0
Heart Mitochondria: Receivers and Transmitters of Signals
Marı́n-Garcı́a, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_8
The Multidimensional Role of Mitochondria in Heart Failure
Marı́n-Garcı́a, J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-147-9_5
Freiberg, F. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-9773
Dying without mitochondrial gene expression
Weitzman, J. B. (2001) · Genome biology · doi:10.1186/gb-spotlight-20010330-02
Mitochondria Play an Essential Role in Heart Failure
Marı́n-Garcı́a, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_18
The pathophysiology of respiratory chain dysfunction
Silva, J. P. (2005) · Figshare
Generació d'un model de malaltia mitocondrial humana en "Drosophila melanogaster"
Guitart, T. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Synthetic Thyroid Hormone and Thyroid Hormone Analogues for Treatment of Heart Failure
Pingitore, A., Lionetti, V., & Forini, F. (2009) · Springer eBooks · doi:10.1007/978-88-470-1143-4_20
Exercise and regulation of mitochondrial biogenesis factors in human skeletal muscle
Norrbom, J. (2008) · Figshare
EUROPEAN SCHOOL OF MOLECULAR MEDICINE
Napoli, S. D. (2010)
Animal Models of Heart Failure
Marı́n-Garcı́a, J. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-147-9_6
The Molecular Cardiology of Heart Block
Hamilton, R. M. (2000) · Developments in cardiovascular medicine · doi:10.1007/978-1-4615-4517-0_8
Identification of novel signaling pathways for cardiomyocyte differentiation and growth
Ye, J. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Síndromes y cardiopatías congénitas en el adulto
Colmenero, J. C. (2002) · Revista Portuguesa de Pneumologia
Current Progress and Future Perspectives: Toward Mitochondrial Medicine
Marı́n-Garcı́a, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_24
On Glucose Metabolism in Patients with the m.3243A>G Mutation
Lindroos, M. M. (2013) · UTUPub (University of Turku)
Age-Related Mitochondrial DNA Depletion and the Impact on Pancreatic Beta Cell
Nile, D. L., Brown, A. E., Kumaheri, M. A., Blair, H., Miwa, S., Cree, L. M., Payne, B. A. I., Chinnery, P. F., Brown, L., Gunn, D. A., et al. (2014)
Metadata
- Authors
- Wang, J., Wilhelmsson, H., Graff, C., Li, H., Oldfors, A., Rustin, P., Brüning, J. C., Kahn, C. R., Clayton, D. A., Barsh, G. S., Thorén, P., & Larsson, N.-G.
- Affiliations
- Karolinska University Hospital (SE)
- Sahlgrenska University Hospital (SE)
- Inserm (FR)
- Joslin Diabetes Center (US)
- Howard Hughes Medical Institute (US)
- Karolinska Institutet (SE)
- Corresponding author
- Larsson, Nils-Göran
- ORCID
- Venue
- Nature Genetics
- Published
- 1999-01
- Volume
- 21
- Issue
- 1
- Pages
- 133-137
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- DOI
- 10.1038/5089
- OpenAlex
- W1548912336
- Cited by
- 435
- References
- 31
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 12 · 2023: 9 · 2022: 7 · 2021: 13 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 16 · 2014: 16 · 2013: 9 · 2012: 21
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r37gm033088-25)
- National Institute of General Medical Sciences (R37-GM33088-28)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- dilated cardiomyopathy, atrioventricular block, mitochondrial DNA mutations, TFAM, Kearns-Sayre syndrome, conditional gene targeting, respiratory chain deficiency, oxidative phosphorylation, mouse model
- MeSH terms
- Animals, Cardiomyopathy, Dilated, Creatine Kinase, Electron Transport Complex IV, Disease Models, Animal, DNA-Binding Proteins, DNA, Mitochondrial, Female, Gene Expression Regulation, Heart, Heart Block, High Mobility Group Proteins, Humans, Male, Mice, Transgenic, Myocardium, Nuclear Proteins, Transcription Factors, Viral Proteins, Trans-Activators, NAD(P)H Dehydrogenase (Quinone), Muscle, Skeletal, Integrases, Mitochondrial Proteins, Xenopus Proteins, Mice
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