Embryo editing sparks epic debate

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

Liang, P., Xu, Y., Zhang, X., Ding, C., Huang, R., Zhang, Z., Lv, J., Xie, X., Chen, Y., Li, Y., et al. (2015) · Protein & Cell · doi:10.1007/s13238-015-0153-5 · Cited by 1,135 · see citing works

A prudent path forward for genomic engineering and germline gene modification

Baltimore, D., Berg, P. R., Botchan, M. R., Carroll, D., Charo, R. A., Church, G. M., Corn, J. E., Daley, G. Q., Doudna, J. A., Fenner, M. W., et al. (2015) · Science · doi:10.1126/science.aab1028 · Cited by 711 · see citing works

Don’t edit the human germ line

Lanphier, E., Urnov, F., Haecker, S. E., Werner, M., & Smolenski, J. (2015) · Nature · doi:10.1038/519410a · Cited by 530 · see citing works

CRISPR–Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing

Gostimskaya, I. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922080090 · Cited by 224 · see citing works

Nanobiohybrids: Materials approaches for bioaugmentation

Guo, Z., Richardson, J. J., Kong, B., & Liang, K. (2020) · Science Advances · doi:10.1126/sciadv.aaz0330 · Cited by 179 · see citing works

Hereditary Nephrogenic Diabetes Insipidus: Pathophysiology and Possible Treatment. An Update

Milano, S., Carmosino, M., Gerbino, A., Svelto, M., & Procino, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112385 · Cited by 91 · see citing works

Highly efficient and precise base editing in discarded human tripronuclear embryos

Li, G., Liu, Y., Zeng, Y., Li, J., Wang, L., Yang, G., Chen, D., Shang, X., Chen, J., Huang, X., et al. (2017) · Protein & Cell · doi:10.1007/s13238-017-0458-7 · Cited by 77 · see citing works

Development and application of CRISPR/Cas9 technologies in genomic editing

Zhang, C., Quan, R., & Wang, J. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy120 · Cited by 77 · see citing works

The genome editing revolution: A CRISPR‐Cas TALE off‐target story

Stella, S., & Montoya, G. (2016) · BioEssays · doi:10.1002/bies.201670903 · Cited by 64 · see citing works

Why Gene Editors Like CRISPR/Cas May Be a Game-Changer for Neuroweapons

DiEuliis, D., & Giordano, J. J. (2017) · Health Security · doi:10.1089/hs.2016.0120 · Cited by 55 · see citing works

Genetic Moderation of Stress Effects on Corticolimbic Circuitry

Bogdan, R., Pagliaccio, D., Baranger, D. A. A., & Hariri, A. R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.216 · Cited by 48 · see citing works

The ethics of clinical applications of germline genome modification: a systematic review of reasons

van Dijke, I., Bosch, L., Bredenoord, A. L., Cornel, M. C., Repping, S., & Hendriks, S. (2018) · Human Reproduction · doi:10.1093/humrep/dey257 · Cited by 44 · see citing works

Is CRISPR an Ethical Game Changer?

Schultz-Bergin, M. (2018) · Journal of Agricultural and Environmental Ethics · doi:10.1007/s10806-018-9721-z · Cited by 41 · see citing works

Recent advances in mammalian reproductive biology

Wen, L., Liu, Q., Xu, J.-J., Liu, X., Shi, C.-Y., Yang, Z., Zhang, Y., Xu, H., Liu, J., Yang, H., et al. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-1572-7 · Cited by 33 · see citing works

Synthetic biology and occupational risk

Howard, J., Murashov, V. V., & Schulte, P. A. (2016) · Journal of Occupational and Environmental Hygiene · doi:10.1080/15459624.2016.1237031 · Cited by 25 · see citing works

Ethical Challenges and Controversies in the Practice and Advancement of Gene Therapy

Ansah, E. O. (2022) · Advances in Cell and Gene Therapy · doi:10.1155/2022/1015996 · Cited by 25 · see citing works

CRISPR-Cas9: A multifaceted therapeutic strategy for cancer treatment

Kaushik, I., Ramachandran, S., & Srivastava, S. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.04.018 · Cited by 24 · see citing works

US Competitiveness in Synthetic Biology

Grönvall, G. K. (2015) · Health Security · doi:10.1089/hs.2015.0046 · Cited by 24 · see citing works

CRISPR/Cas9 system and its applications in human hematopoietic cells

Hu, X. (2016) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2016.09.003 · Cited by 20 · see citing works

Next-generation CRISPR technology for genome, epigenome and mitochondrial editing

Lau, C., Liang, Q., & Zhu, H. (2024) · Transgenic Research · doi:10.1007/s11248-024-00404-x · Cited by 18 · see citing works

Gender-specific medicine in the genomic era

Legato, M. J. (2015) · Clinical Science · doi:10.1042/cs20150551 · Cited by 18 · see citing works

Ethical issues in human germline gene editing: a perspective from China

Zhang, D., & Lie, R. K. (2018) · Bioethics News · doi:10.1007/s40592-018-0091-0 · Cited by 18 · see citing works

Genome editing and international regulatory challenges: Lessons from Mexico

Chan, S., & Arellano, M. D. J. M. (2016) · Ethics Medicine and Public Health · doi:10.1016/j.jemep.2016.05.001 · Cited by 18 · see citing works

From the first human gene-editing to the birth of three-parent baby

Zhang, X., & Wang, S. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-0358-3 · Cited by 9 · see citing works

A double-edged sword: CRISPR-Cas9 is emerging as a revolutionary technique for genome editing

Li, C., & Qian, H. (2015) · Military Medical Research · doi:10.1186/s40779-015-0054-1 · Cited by 8 · see citing works

Editing the Genome of Human Being

de Araújo, M. (2017) · Journal of Ethics and Emerging Technologies · doi:10.55613/jeet.v27i1.65 · Cited by 8 · see citing works

From hacking the human genome to editing organs

Tobita, T., Guzman‐Lepe, J., & de l’Hortet, A. C. (2015) · Organogenesis · doi:10.1080/15476278.2015.1120047 · Cited by 7 · see citing works

Voting on Embryonic Stem Cell Research: Citizens More Supportive than Politicians

Stadelmann, D., & Torgler, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170656 · Cited by 6 · see citing works

Recent Advances in Therapeutic Genome Editing in China

Yang, Y., Wang, Q., Li, Q., Men, K., He, Z., Deng, H., Ji, W., & Wei, Y. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.210 · Cited by 6 · see citing works

The genome editing revolution: A CRISPR-Cas TALE off-target story

Stella, S., & Montoya, G. (2015) · Inside the Cell · doi:10.1002/icl3.1038 · Cited by 6 · see citing works

Gene Editing in Clinical Practice

Mittal, R. D. (2017) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-017-0720-z · Cited by 6 · see citing works

Not just “a clever way to detect whether DNA really made RNA”1: The invention of DNA–RNA hybridization and its outcome1Judson (1979, p. 440).

Fisher, S. (2015) · Studies in History and Philosophy of Science Part C Studies in History and Philosophy of Biological and Biomedical Sciences · doi:10.1016/j.shpsc.2015.07.002 · Cited by 5 · see citing works

Impact of Gene Editing Tools, Like CRISPR/Cas9, on the Public Health Response to Disease Outbreaks

Pope, S. M. (2016) · Disaster Medicine and Public Health Preparedness · doi:10.1017/dmp.2016.123 · Cited by 5 · see citing works

CRISPR/Cas9: Edición Genética vs. Bioética

Yabar, M. L. P. (2019) · Apuntes de bioética · doi:10.35383/apuntes.v2i1.238 · Cited by 4 · see citing works

Emerging Life Sciences: New Challenges to Strategic Stability

Kosal, M. E. (2019) · Advanced sciences and technologies for security applications · doi:10.1007/978-3-030-28342-1_3 · Cited by 4 · see citing works

Biotechnology: Discoveries and Their Applications in Societal Welfare

Kumar, H. (2020) · Ecoproduction · doi:10.1007/978-3-030-36130-3_1 · Cited by 4 · see citing works

Governance of Emerging Biotechnologies: Lessons from Two Chinese Cases

Zhang, H., Cuilian, Z., Wang, J., Yang, Y., Wei, Y., Zhang, Z., & Yu-ming, W. (2021) · The American Journal of Bioethics · doi:10.1080/15265161.2021.2001110 · Cited by 4 · see citing works

Gene Editing and Germ-line Intervention: The Need for Novel Responses to Novel Technologies

Addison, C., & Taylor‐Alexander, S. (2015) · Molecular Therapy · doi:10.1038/mt.2015.185 · Cited by 3 · see citing works

Crossing the Germline Barrier: The Three Genome Baby

Krimsky, S. (2015) · Ethics in Biology Engineering and Medicine An International Journal · doi:10.1615/ethicsbiologyengmed.2016016331 · Cited by 3 · see citing works

Between Moral Hazard and Legal Uncertainty

Braun, M., Schickl, H., & Dabrock, P. (2018) · Technikzukünfte, Wissenschaft und Gesellschaft · doi:10.1007/978-3-658-22660-2_1 · Cited by 3 · see citing works

What Does It Mean to Be Human? (Biological Sciences, Biotechnology, and Other Considerations)

Luokkala, B. B. (2019) · Science and fiction · doi:10.1007/978-3-030-29393-2_6 · Cited by 2 · see citing works

Nephrogenic Diabetes Insipidus Affecting Three Males in Two Generations—Case Report and Review of the Literature

Stroescu, R. F., Chiriță-Emandi, A., Puiu, M., Chisavu, F., Steflea, R. M., Doros, G. S., & Gafencu, M. (2025) · Children · doi:10.3390/children12020195 · Cited by 1 · see citing works

CRISPR/Cas9-Mediated Genome Nano-Surgery: An Update

Mokbel, K., & Mokbel, K. (2017) · Biochemistry & Molecular Biology Journal · doi:10.21767/2471-8084.100042 · Cited by 1 · see citing works

Excitation et crispations autour de CRISPR : lorsque la réalité dépasse la science-fiction

Kaplan, J. (2016) · Les Cahiers de Myologie · doi:10.1051/myolog/201613015 · Cited by 1 · see citing works

Determining HIV-1 quasispecies genomic variability to optimize gRNA excision using the CRISPR/Cas9 gene editing system

DeSimone, M. F., Dampier, W., & Saçan, A. (2015) · doi:10.17918/etd-6497

In vivo imaging of the early embryonic cortex in rodents

Yuryev, M. V. (2017) · Työväentutkimus Vuosikirja

Medical Humanity and Inhumanity in the German-Speaking World

Schonfield, E. (2020) · UCL Press eBooks · doi:10.14324/111.9781787357716

CRISPR/CAS και η επέμβαση στο ανθρώπινο γονιδίωμα: περί φύσης και έξης

Χασαπάκου, Δ., Προϊκάκη, Σ., Μπόμπολα, Μ., & Lambrou, G. Ι. (2018) · Bioethica · doi:10.12681/bioeth.19696

CRISPR-Cas systems ushered in an era of facile DNA-free genome editing

Ajay, J., & Rai, V. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.09.007

The Legal Framework of New Zealand Concerning Germline Interventions

Sargent, A. (2019) · Veröffentlichungen des Instituts für Deutsches, Europäisches und Internationales Medizinrecht, Gesundheitsrecht und Bioethik der Universitäten Heidelberg und Mannheim · doi:10.1007/978-3-662-59028-7_11

The ART of Authenticity

Beck, B. (2020) · The International Library of Bioethics · doi:10.1007/978-3-030-56703-3_6

A human rights analysis of clustered regularly interspaced short palindromic repeats germline-editing for disease prevention

Shaver, L. G., Sundly, A., & Saif, A. O. (2020) · Journal of Public Health and Primary Care · doi:10.4103/jphpc.jphpc_21_20

Faculty Opinions recommendation of Hereditary nephrogenic diabetes insipidus: pathophysiology and possible treatment. an update.

Valenti, G., & Tamma, G. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732099898.793555510

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原始科研创新是发展中国高质量学术期刊的必由之路

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Chinese scientists genetically modify human embryos

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Genes & cells: Editing human germline cells debated: New techniques for modifying genes raise ethical questions

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Ethics of embryo editing paper divides scientists

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Scientists split over value of moratorium on editing the human germline

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