Diabetes: Encapsulating the problem

Dolgin, Elie

doi:10.1038/540s60a

Cited by 43Pancreatic function and diabetesDiabetes and associated disordersDiabetes Management and Research

Diabetes: Encapsulating the problem

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Dolgin, Elie·2016·Nature

DOI 10.1038/540s60a

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Some endocrine cells were observed, but fibrosis around the capsule resulted in graft loss, and no insulin secretion from the device was detected.
“While some endocrine cells were observed, fibrosis around the capsule resulted in graft loss, and no insulin secretion from the device was detected.33,34”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [34]
In “Bounding into the Clinic” (page not specified), the paper says pancreatic precursors in ViaCyte’s device grew into insulin-producing β-cells in many recipients, but often died after a few months because of a fibrotic reaction on the device exterior. It does not say that no insulin secretion from the device was detected. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Macroencapsulation devices can promote fibrosis around the implant, further preventing nutrient diffusion.
“these macroencapsulation devices can also promote fibrosis around the implant, further preventing nutrient diffusion.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [34]

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Authors: Dolgin, E.
Corresponding author: Dolgin, Elie
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2016-12
Volume: 540
Issue: 7632
Pages: S60-S62
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/540s60a
OpenAlex: W2560772808
Cited by: 43
References: 6
Citations by year: 2026: 1 · 2025: 3 · 2024: 5 · 2023: 2 · 2021: 6 · 2020: 5 · 2019: 10 · 2018: 4 · 2017: 7
FWCI: 7.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 1 diabetes, cell therapy, immune system, autoimmunity, diabetes cure
MeSH terms: Alginates, Animals, Diabetes Mellitus, Type 1, Graft Rejection, Hexuronic Acids, Humans, Islets of Langerhans, Islets of Langerhans Transplantation, Glucuronic Acid, Induced Pluripotent Stem Cells, Cell- and Tissue-Based Therapy

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Diabetes: Encapsulating the problem

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