The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
Abstract
To evaluate the utility of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a cancer therapeutic, we created leucine zipper (LZ) forms of human (hu) and murine (mu) TRAIL to promote and stabilize the formation of trimers. Both were biologically active, inducing apoptosis of both human and murine target cells in vitro with similar specific activities. In contrast to the fulminant hepatotoxicity of LZ-huCD95L in vivo, administration of either LZ-huTRAIL or LZ-muTRAIL did not seem toxic to normal tissues of mice. Finally, repeated treatments with LZ-huTRAIL actively suppressed growth of the TRAIL-sensitive human mammary adenocarcinoma cell line MDA-231 in CB.17 (SCID) mice, and histologic examination of tumors from SCID mice treated with LZ-huTRAIL demonstrated clear areas of apoptotic necrosis within 9-12 hours of injection.
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“MDA-231 cells have been shown to be TRAIL-sensitive because the injection of recombinant TRAIL into MDA-231 tumor-bearing mice led to significant antitumor effects and increased mouse survival (360).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [360]
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Self-citationFas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
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Self-citationThe TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
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Self-citationOld, L. J. (1985) · Science · doi:10.1126/science.2413547 · Cited by 1,885
Lethal effect of the anti-Fas antibody in mice
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Self-citationInduction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family
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The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Safety and antitumor activity of recombinant soluble Apo2 ligand
Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6926 · Cited by 2,213
Death and anti-death: tumour resistance to apoptosis
Igney, F. H., & Krammer, P. H. (2002) · Nature reviews. Cancer · doi:10.1038/nrc776 · Cited by 2,073
Cytokines in cancer pathogenesis and cancer therapy
Dranoff, G. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1252 · Cited by 1,660
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
Ashkenazi, A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc821 · Cited by 1,351
Metadata
- Authors
- Walczak, H., Miller, R. E., Ariail, K., Gliniak, B., Griffith, T. S., Kubin, M., Chin, W., Jones, J., Woodward, A., Le, T., Smith, C., Smolak, P., Goodwin, R. G., Rauch, C. T., Schuh, J. C. L., & Lynch, D. H.
- Corresponding author
- Lynch, David H.
- ORCID
- Venue
- Nature Medicine
- Published
- 1999-02
- Volume
- 5
- Issue
- 2
- Pages
- 157-163
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- DOI
- 10.1038/5517
- OpenAlex
- W1484817497
- Cited by
- 2,497
- References
- 48
- Citations by year
- 2026: 20 · 2025: 24 · 2024: 33 · 2023: 58 · 2022: 47 · 2021: 57 · 2020: 57 · 2019: 63 · 2018: 64 · 2017: 73 · 2016: 76 · 2015: 80 · 2014: 84 · 2013: 94 · 2012: 96
- FWCI
- 41.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Toxin Mechanisms and Immunotoxins
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, leucine zipper, Fas ligand, apoptosis, tumor growth inhibition, hepatotoxicity, SCID mice, TNF receptor, cancer therapy
- MeSH terms
- Animals, Antineoplastic Agents, Dose-Response Relationship, Drug, Humans, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Protein Conformation, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Mice, SCID, Apoptosis, Apoptosis Regulatory Proteins, Mice, TNF-Related Apoptosis-Inducing Ligand, Fas Ligand Protein
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