Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, Gabriel T., Jackson-Lewis, Vernice, Vukosavic, Slobodanka, Mandir, Allen S., Vila, Miquel, McAuliffe, W. Geoffrey, Dawson, Valina L., Dawson, Ted M., Przedborski, Serge·1999·Nature Medicine

DOI 10.1038/70978

Cited by (1,000)

Items 601–700 of 1,000

The Central Role of Biometals Maintains Oxidative Balance in the Context of Metabolic and Neurodegenerative Disorders
Michal Pokusa, Alzbeta Kralova Trancikova · 2017 · Oxidative Medicine and Cellular Longevity
Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson's disease
Carla Nunes, João A.N. Laranjinha · 2021 · Archives of Biochemistry and Biophysics
Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: From experimental models to neurodegenerative diseases
Paolo Gubellini, Barbara Picconi, Massimiliano Di Filippo, Paolo Calabresi · 2009 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
The inflammatory response in the Parkinson brain
Stéphane Hunot, Andreas Hartmann, Étienne C. Hirsch · 2001 · Clinical Neuroscience Research
Effects of estrogen against LPS-induced inflammation and toxicity in primary rat glial and neuronal cultures
Meytal Tenenbaum, Abed N. Azab, JACOB KAPLANSKI · 2007 · Journal of Endotoxin Research
Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one), a Radical Scavenger, Prevents 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Neurotoxicity in the Substantia Nigra but Not the Striatum
Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Akemichi Baba, Toshio Matsuda · 2007 · Journal of Pharmacology and Experimental Therapeutics
Viral-toxin interactions and Parkinson’s disease: poly(I:C) priming enhanced the neurodegenerative effects of paraquat
Jessica Bobyn, Emily N. Mangano, Anusha Gandhi, Eric Nelson, Kerry Moloney, Melanie Clarke, Shawn P. Hayley · 2012 · Journal of Neuroinflammation
Inflammation in parkinson’s disease
Andreas Hald, Johan van Beek, Julie Lotharius · 2007 · Sub-cellular biochemistry/Subcellular biochemistry
Activation of constitutive nitric oxide synthase(s) and absence of inducible isoform in aged rat brain
Henryk M. Jęśko, Małgorzata Chalimoniuk, Joanna Benigna Strosznajder · 2002 · Neurochemistry International
Establishment of modified chimeric mice using GFP bone marrow as a model for neurological disorders
Tsuyoshi Furuya, Ryota Tanaka, Takao Urabe, Jun Hayakawa, Makoto Migita, Takashi Shimada, Yoshikuni Mizuno, Hideki Mochizuki · 2003 · Neuroreport
Therapeutic Effect of Neuronal Nitric Oxide Synthase Inhibitor (7-Nitroindazole) against MPTP Neurotoxicity in Mice
Y. Muramatsu, R. Kurosaki, T. Mikami, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai, Hisanori Kato, Yasuto Itoyama, Tsutomu Araki · 2002 · Metabolic Brain Disease
Mitochondrial damage by nitric oxide is potentiated by dopamine in PC12 cells
Fernando Antunes, Derick Han, Daniel Rettori, Enrique Cadenas · 2002 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson’s Disease
Heeyoung An, Hyowon Lee, Seulkee Yang, Woojin Won, Changjoon Justin Lee, Min‐Ho Nam · 2021 · Experimental Neurobiology
Acute Neuroimmune Modulation Attenuates the Development of Anxiety-Like Freezing Behavior in an Animal Model of Traumatic Brain Injury
Krista M. Rodgers, Florencia M. Bercum, Danielle L. McCallum, Jerry W. Rudy, Lauren C. Frey, Kirk W. Johnson, Linda R. Watkins, Daniel S. Barth · 2012 · Journal of Neurotrauma
Toxicity of MPTP on neurotransmission in three mouse models of Parkinson's disease
Stéphanie Pain, Alice Gochard, Sylvie Bodard, Zuhal Gulhan, Caroline Prunier‐Aesch, Sylvie Chalon · 2012 · Experimental and Toxicologic Pathology
Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats
K.S. Madathil, Saravanan S. Karuppagounder, Reena Haobam, Merina Varghese, Usha Rajamma, Kochupurackal P. Mohanakumar · 2013 · Neurochemistry International
Opposite Effects of Bone Marrow-Derived Cells Transplantation in MPTP-rat Model of Parkinson's Disease: A Comparison Study of Mononuclear and Mesenchymal Stem Cells
Caroline Santos Capitelli, Carolina Salomão Lopes, Angélica Cristina Alves, Janaína K. Barbiero, Lucas Felipe de Oliveira, Valdo José Dias da Silva, Maria A.B.F. Vital · 2014 · International Journal of Medical Sciences
Long-term Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson’s Disease
Dongping Huang, Zishan Wang, Jiabin Tong, Mo Wang, Jinghui Wang, Jing Xu, Xiaochen Bai, Heng Li, Yulu Huang, Yufei Wu et al. · 2017 · Neuroscience
Alterations in Energy Metabolism, Neuroprotection and Visual Signal Transduction in the Retina of Parkinsonian, MPTP-Treated Monkeys
Laura Campello, Julián Esteve-Rudd, Roque Bru‐Martínez, María Trinidad Herrero, Emiliano Fernández‐Villalba, Nicolás Cuenca, José Martín‐Nieto · 2013 · PLoS ONE
Gene Deletion of nos2 Protects Against Manganese-Induced Neurological Dysfunction in Juvenile Mice
Karin M. Streifel, Julie A. Moreno, William H. Hanneman, Marie E. Legare, Ronald B. Tjalkens · 2011 · Toxicological Sciences
Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis
David L. Carbone, Katriana A. Popichak, Julie A. Moreno, Stephen H Safe, Ronald B. Tjalkens · 2008 · Molecular Pharmacology
Bimodal induction of dopamine-mediated striatal neurotoxicity is mediated through both activation of D1 dopamine receptors and autoxidation
Christophe Wersinger, Jun Chen, Anita Sidhu · 2003 · Molecular and Cellular Neuroscience
NOS2A and the modulating effect of cigarette smoking in Parkinson's disease
Dana B. Hancock, E. Martin, K. Fujiwara, Mark A. Stacy, B. Scott, J. Stajich, Rita M. Jewett, Yi-Ju Li, Michael A. Hauser, J. Vance et al. · 2006 · Annals of Neurology
A neurotherapeutic approach with Lacticaseibacillus rhamnosus E9 on gut microbiota and intestinal barrier in MPTP-induced mouse model of Parkinson’s disease
Büşra Aktaş, Belma Aslım, Deniz Ateş Özdemir · 2024 · Scientific Reports
Effects of simvastatin on the expression of inducible nitric oxide synthase and brain-derived neurotrophic factor in a lipopolysaccharide-induced rat model of Parkinson disease
Tan Wang, Cao Xue-bin, Tian Zhang, Xiaowu Chen, Huang Peipei, Zhibin Chen, Tang Beisha · 2015 · International Journal of Neuroscience
Meloxicam protects cell damage from 1-methyl-4-phenyl pyridinium toxicity via the phosphatidylinositol 3-kinase/Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells
Yoshikazu Tasaki, Tomohiro Omura, Takehiro Yamada, Tomoko Ohkubo, Manabu Suno, Shinya Iida, Tomoki Sakaguchi, Masaru Asari, Keiko Shimizu, Kazuo Matsubara · 2010 · Brain Research
Attenuation of neuroinflammatory responses and behavioral deficits by Ligusticum officinale (Makino) Kitag in stimulated microglia and MPTP-induced mouse model of Parkinson׳s disease
Byung-Wook Kim, Sushruta Koppula, Shin‐Young Park, Yon-Suk Kim, Pyo‐Jam Park, Ji-Hong Lim, In‐Su Kim, Dong‐Kug Choi · 2014 · Journal of Ethnopharmacology
Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice
Xijun He, Kazuyuki Uchida, Chiaki Megumi, Nobuaki Tsuge, Hiroyuki Nakayama · 2015 · Journal of Toxicologic Pathology
Parkinson Disease: Translating Insights from Molecular Mechanisms to Neuroprotection
Sheila K. Pirooznia, Liana S. Rosenthal, Valina Lynn Dawson, Ted M. Dawson · 2021 · Pharmacological Reviews
Ghrelin protects dopaminergic neurons against MPTP neurotoxicity through promoting autophagy and inhibiting endoplasmic reticulum mediated apoptosis
Wang, Huiqing, Dou, Shanshan, Zhu, Junge, Shao, Ziqi, Wang, Chunmei, Cheng, Baohua · 2020 · Brain Research
Development of Urea and Thiourea Kynurenamine Derivatives: Synthesis, Molecular Modeling, and Biological Evaluation as Nitric Oxide Synthase Inhibitors
Mariem Chayah, María Dora Carriòn, Miguel Á. Gallo, Rosario Jiménez, Juan Duarte, María Encarnación Camacho · 2015 · ChemMedChem
Effects of Ranolazine on Astrocytes and Neurons in Primary Culture
Martı́n Aldasoro, Sol Guerra‐Ojeda, Diana Aguirre-Rueda, María Dolores Mauricio, José M. Vila, Patricia Marchio, Antonio Iradi, Constanza Aldasoro, Adrián Jorda, Elena Obrador et al. · 2016 · PLoS ONE
Puerarin prevents inflammation and apoptosis in the neurocytes of a murine Parkinson's disease model
M. Jiang, Q. Yun, G. Niu, Yi Gao, Fei Shi, S. Yu · 2016 · Genetics and Molecular Research
N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice
Rosalia Crupi, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Giovanna Casili, Maurizio Evangelista, Salvatore Cuzzocrea · 2018 · Molecular Neurobiology
Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model
Jing Lu, Liyan Hou, Dongdong Zhang, Sheng Li, Zhengzheng Ruan, Xiaomeng Zhang, Jau‐Shyong Hong, Qingshan Wang · 2021 · Journal of Inflammation Research
Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease
Jason R. Richardson, Muhammad M. Hossain · 2013 · Neural Plasticity
Current Development of Acupuncture Research in Parkinson's Disease
Bai‐Yun Zeng, Sarah Salvage, Peter G. Jenner · 2013 · International review of neurobiology
The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease
Neus Rabaneda‐Lombarte, Joan Serratosa, Jordi Bové, Miquel Vila, Josep Saura, Carme Solà · 2021 · Journal of Neuroinflammation
Proliferation of microglial cells induced by 1‐methyl‐4‐phenylpyridinium in mesencephalic cultures results from an astrocyte‐dependent mechanism: role of granulocyte macrophage colony‐stimulating factor
Carmen Henze, Andreas Hartmann, Thomas Lescot, Étienne C. Hirsch, Patrick Pierre Michel · 2005 · Journal of Neurochemistry
Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy
Mendes, Mariana Oliveira, Rosa, Alexandra Isabel, Carvalho, Andreia Neves, Nunes, Maria João, Dionísio, Pedro, Rodrigues, Elsa, Costa, Daniela, Duarte-Silva, Sara, Maciel, Patrícia, Rodrigues, Cecília Maria Pereira et al. · 2019 · Molecular and Cellular Neuroscience
Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo
Xiaolong Hu, Jun Lin, Xian-Yu Lv, Jiahao Feng, Xiao‐Qi Zhang, Hao Wang, Wen‐Cai Ye · 2018 · European Journal of Medicinal Chemistry
Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions
Stefania Kalampokini, Anouck Becker, Klaus C Fassbender, Epameinondas Lyros, Marcus Michael Unger · 2019 · Parkinson s Disease
Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review
Mobina Fathi, Kimia Ghazi Vakili, Shirin Yaghoobpoor, Mohammad Sadegh Qadirifard, Mohammadreza Kosari, Navid Naghsh, Afsaneh Asgari Taei, Andis Klegeris, Mina Dehghani, Ashkan Bahrami et al. · 2022 · Frontiers in Aging Neuroscience
2,5-Hexanedione induces dopaminergic neurodegeneration through integrin αMβ2/NADPH oxidase axis-mediated microglial activation
Cong Zhang, Liyan Hou, Jie Yang, Yuning Che, Fuqiang Sun, Hui‐Hua Li, Qingshan Wang · 2018 · Cell Death and Disease
Diaminonaphthalene Boronic Acid (DANBA): New Approach for Peroxynitrite Sensing Site
Jiankang Gong, Xiaoyu Wang, Jiao Wu, Changyu Yoon, Yujin Kim, Jingwen Zou, Zhiqiang Mao, Jong Seung Kim · 2024 · Angewandte Chemie International Edition
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease
Brent James Ryan, Lara Lourenço Venda, Mark J. Crabtree, Ashley Hale, Keith M. Channon, Richard Wade‐Martins · 2013 · Free Radical Biology and Medicine
The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications
Katarzyna Z. Kuter, Maria Angela Cenci, Anna Rosa Carta · 2020 · Progress in brain research
The specific Na+/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells
Tetsuaki Nashida, Kazuhiro Takuma, Sayoko Fukuda, Toshiyuki Kawasaki, Teisuke Takahashi, Akemichi Baba, Yukio Ago, Toshio Matsuda · 2011 · Neurochemistry International
Strategic Selection of Neuroinflammatory Models in Parkinson's Disease: Evidence from Experimental Studies
Sandeep Vasant More, Hemant Kumar, In‐Su Kim, Sushruta Koppula, Byung-Wook Kim, Dong‐Kug Choi · 2013 · CNS & Neurological Disorders - Drug Targets
Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
Edel T. Kavanagh, Miguel Ángel Burguillos, Alejandro Carrillo-Jiménez, Maria José Oliva-Martín, Martiniano Santiago, Johanna Rodhe, Bertrand Joseph, Jose Luis Venero · 2015 · Aging
Novel insight into the mechanisms involved in the regulation of the m1 muscarinic receptor, iNOS and nNOS mRNA levels
Leonor Sterin‐Borda, Sabrina Ganzinelli, Alejandro Berra, Enri Borda · 2003 · Neuropharmacology
The Nitric Oxide-Cyclic GMP Pathway Regulates FoxO and Alters Dopaminergic Neuron Survival in Drosophila
Tomoko Kanao, Tomoyo Sawada, Shireen-Anne Davies, Hiroshi Ichinose, Kazuko Hasegawa, Ryōsuke Takahashi, Nobutaka Hattori, Yuzuru Imai · 2012 · PLoS ONE
Altered regulation of iron transport and storage in Parkinson’s disease
Étienne C. Hirsch · 2006 · Springer eBooks
Novel Anti-Inflammatory and Neuroprotective Agents for Parkinsons Disease
Li Lü, Fengqiao Li, Xiaomin Wang · 2010 · CNS & Neurological Disorders - Drug Targets
Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γAgonist against MPTP
Christine R. Swanson, Eric Yiwei Du, Delinda A. Johnson, Jeffrey Allan Johnson, Marina Elena Emborg · 2013 · PPAR Research
RETRACTED ARTICLE: Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism
Sathiya Sekar, Sugumar Mani, Barathidasan Rajamani, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Abid Bhat, Bipul Ray, Musthafa Mohamed Essa, Gilles J. Guillemin, Saravana Babu Chidambaram · 2018 · Neurotoxicity Research · Retracted
Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells
Shinrye Lee, Yu‐Mi Jeon, Myungjin Jo, Hyung‐Jun Kim · 2021 · Experimental Neurobiology
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation
Liyan Hou, Jianing Liu, Fuqiang Sun, Ruixue Huang, Rui Chang, Zhengzheng Ruan, Ying Wang, Jie Zhao, Qingshan Wang · 2023 · Journal of Neuroinflammation
TGFβ1 and TNFα potentiate nitric oxide production in astrocyte cultures by recruiting distinct subpopulations of cells to express NOS-2
Mary E. Hamby, Ariel R. Gragnolati, Sandra J. Hewett, James A. Hewett · 2007 · Neurochemistry International
Investigation of diverse interactions of amino acids (Asp and Glu) in aqueous Dopamine hydrochloride with the manifestation of the catecholamine molecule recognition tool in solution phase
Ananya Yasmin, Siti Barman, Biraj Kumar Barman, Mahendra Nath Roy · 2018 · Journal of Molecular Liquids
Effects of riluzole on combined MPTP?+?3-nitropropionic acid-induced mild to moderate striatonigral degeneration in mice
Elsa Diguet, Pierre‐Olivier Fernagut, Christoph Scherfler, Gregor Karl Wenning, François Tison · 2004 · Journal of Neural Transmission
Novel nitrates as NO mimetics directed at Alzheimer's disease
Gregory R. J. Thatcher, Brian M. Bennett, Hans C. Dringenberg, James N. Reynolds · 2005 · Journal of Alzheimer s Disease
1‐methyl‐4‐phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase
Martine Barkats, Philippe Horellou, Philippe Colin, Stéphanie Millecamps, Nicole Faucon Biguet, Jacques J. Mallet · 2005 · Journal of Neuroscience Research
Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline
Sylvie Cornet, Brigitte Spinnewyn, Sylvie Delaflotte, Christelle Charnet, Véronique Roubert, Christine Favre, Hamida Hider, Pierre Etienne Chabrier, Michel Auguet · 2004 · European Journal of Pharmacology
Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC)Implications for Parkinson's disease
Carla Nunes, Leonor M. Almeida, João A.N. Laranjinha · 2005 · Neurochemistry International
Astroglial Nitration after Postnatal Excitotoxic Damage: Correlation with Nitric Oxide Sources, Cytoskeletal, Apoptotic and Antioxidant Proteins
Laia Acarín, Hugo Peluffo, Luis Barbeito, Bernardo Castellano, Berta González · 2005 · Journal of Neurotrauma
Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease
Ludovico Arcuri, Riccardo Viaro, Simone Bido, Francesco Longo, Mariangela Calcagno, Pierre‐Olivier Fernagut, Nurulain T. Zaveri, Girolamo Calò, Erwan Bézard, Michele Morari · 2016 · Neurobiology of Disease
Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice
Chao Huang, Wenjing Ma, Qihui Luo, Liangqin Shi, Yu Xia, Chengjie Lao, Wentao Liu, Yuanfeng Zou, Anchun Cheng, Riyi Shi et al. · 2019 · Aging
Minireview on the Relations between Gut Microflora and Parkinson’s Disease: Further Biochemical (Oxidative Stress), Inflammatory, and Neurological Particularities
Ovidiu‐Dumitru Ilie, Alin Stelian Ciobica, Jack McKenna, Bogdan Doroftei, Ioannis Asterios Mavroudis · 2020 · Oxidative Medicine and Cellular Longevity
Histo- and immunocytochemical detection of inducible NOS and TNF-α in the locus coeruleus of human opiate addicts
Inessa V. Dyuizen, Nina E. Lamash · 2008 · Journal of Chemical Neuroanatomy
No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes
Cecilia Huerta, Elena Sánchez-Ferrero, Eliécer Coto, Marta Blázquez Estrada, René Ribacoba, Luis M. Guisasola, Carlos Salvador, Victoria Álvarez · 2006 · Neuroscience Letters
Lithospermic acid attenuates 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuroinflammatory pathways
Yun‐Lian Lin, Huey-Jen Tsay, Tzu-Hsuan Lai, Tsai-Teng Tzeng, Young‐Ji Shiao · 2015 · Journal of Biomedical Science
Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation
Yanjing Yang, Shu Zhang, Jianhua Ding, Fang Zhou, Gang Hu · 2008 · The International Journal of Neuropsychopharmacology
Glioprotective Effects of Lingonberry Extract Against Altered Cellular Viability, Acetylcholinesterase Activity, and Oxidative Stress in Lipopolysaccharide-Treated Astrocytes
Simone Muniz Pacheco, Juliana H. Azambuja, Taíse Rosa de Carvalho, Mayara Sandrielly Pereira Soares, Pathise Souto Oliveira, Elita Ferreira da Silveira, Francieli Moro Stefanello, Elizandra Braganhol, Jessié Martins Gutierres, Rosélia Maria Spanevello · 2018 · Cellular and Molecular Neurobiology
Association analysis of a neural nitric oxide synthase gene polymorphism and antipsychotics-induced tardive dyskinesia in Chinese schizophrenic patients
Y.-C. Wang, Ying‐Jay Liou, Ding‐Lieh Liao, Ya‐Mei Bai, C.-C. Lin, S.-C. Yu, J.-Y. Chen · 2004 · Journal of Neural Transmission
Luteolin reduces primary hippocampal neurons death induced by neuroinflammation
Li-Hong Zhu, Wei Bi, Renbin Qi, Huadong Wang, Zhi-Gang Wang, Qi Zeng, Yanru Zhao, Daxiang Lu · 2011 · Neurological Research
Antiparkinsonian Drugs and Their Neuroprotective Effects.
Yoshihisa Kitamura, Jun‐ichi Kakimura, Takashi Taniguchi · 2002 · Biological and Pharmaceutical Bulletin
The associative type of sensitization to d-amphetamine is expressed as an NO-dependent dramatic increase in extracellular dopamine in the nucleus accumbens
I. I. Afanas’ev, Boris Ferger, Klaus Kuschinsky · 2000 · Naunyn-Schmiedeberg s Archives of Pharmacology
Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model
Indrani Datta, S. R. Mekha, Alka Kaushal, Kavina Ganapathy, Rema Razdan · 2019 · Naunyn-Schmiedeberg s Archives of Pharmacology
The Pathological Role of Astrocytic MAOB in Parkinsonism Revealed by Genetic Ablation and Over-expression of MAOB
Heeyoung An, Jun Young Heo, Changjoon Justin Lee, Min‐Ho Nam · 2021 · Experimental Neurobiology
Involvement of the Fcγ Receptor in a Chronic N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Dopaminergic Loss
Arman Lira, Jerzy Kulczycki, Ruth S. Slack, Hymie Anisman, David S. Park · 2011 · Journal of Biological Chemistry
Does Restraining Nitric Oxide Biosynthesis Rescue from Toxins-Induced Parkinsonism and Sporadic Parkinson's Disease?
Satya P. Gupta, Sharawan Yadav, Naveen Kumar Singhal, Manindra Nath Tiwari, Sarad Kumar Mishra, Mahendra Pratap Singh · 2013 · Molecular Neurobiology
The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells, C6
Rituraj Niranjan, N. Rajasekar, Chandishwar Nath, Rakesh Shukla · 2012 · Chemico-Biological Interactions
Nitric oxide–cyclic GMP signaling pathway limits inflammatory degeneration of midbrain dopaminergic neurons: Cell type-specific regulation of heme oxygenase-1 expression
Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuki · 2008 · Neuroscience
Treatment with 1,2,3,4-tetrahydroisoquinolone affects the levels of nitric oxide, S-nitrosothiols, glutathione and the enzymatic activity of γ-glutamyl transpeptidase in the dopaminergic structures of rat brain
Elżbieta Lorenc‐Koci, Maria M Sokołowska, Inga Kwiecień, Lidia B Włodek · 2005 · Brain Research
SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease
Yukio Ago, Toshiyuki Kawasaki, Tetsuaki Nashida, Yuki Ota, Yana Cong, Mari Kitamoto, Teisuke Takahashi, Kazuhiro Takuma, Toshio Matsuda · 2011 · Neuropharmacology
C-Jun N-terminal kinase inhibition and α-tocopherol protect midbrain dopaminergic neurons from interferon-γ/lipopolysaccharide-induced injury without affecting nitric oxide production
Haruki Shibata, Hiroshi Katsuki, Mitsugi Okawara, Toshiaki Kume, Akinori Akaike · 2005 · Journal of Neuroscience Research
Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson’s disease mice
Xiaochen Bai, Xiaoshuang Zhang, Rong Fang, Jinghui Wang, Yuanyuan Ma, Zhaolin Liu, Hongtian Dong, Qing Li, Jingyu Ge, Mei Yu et al. · 2021 · Aging
Effect of sex and gonadectomy on brain MPTP toxicity and response to dutasteride treatment in mice
Amandine Isenbrandt, Marc Morissette, Mélanie Bourque, Jérôme Lamontagne‐Proulx, Katherine Coulombe, Denis Soulet, Thérèse Di Paolo · 2021 · Neuropharmacology
Neuroprotective Effects of a Traditional Multi-Herbal Medicine Kyung-Ok-Ko in an Animal Model of Parkinson's Disease: Inhibition of MAPKs and NF-κB Pathways and Activation of Keap1-Nrf2 Pathway
Jong Hee Choi, Minhee Jang, Joon-Il Lee, Won‐Seok Chung, Ik‐Hyun Cho · 2018 · Frontiers in Pharmacology
Contribution of glutamatergic signaling to nitrosative stress‐induced protein misfolding in normal brain aging and neurodegenerative diseases
Tomohiro Nakamura, Zezong Gu, Stuart A. Lipton · 2007 · Aging Cell
Pathophysiology of Parkinson's disease
Allen S. Mandir, Christina L. Vaughan · 2000 · International Review of Psychiatry
GDNF and TGF-β1 promote cell survival in serum-free cultures of primary rat microglia
Kayvon Salimi, Karma V. Moser, Josef Marksteiner, Markus Reindl, Christian Humpel · 2003 · Cell and Tissue Research
Complement 3-deficient mice are not protected against MPTP-induced dopaminergic neurotoxicity
Yajie Liang, Shurong Li, Qiang Guo, Yanliang Zhang, Can Wen, Qiang Zou, Bingyin Su · 2007 · Brain Research
CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration
Fabrine Sales Massafera Tristão, Márcio Lazzarini, Sabine Martin, Majid Amar, Walter Stühmer, Frank Kirchhoff, Lucas Caldi Gomes, Laurence Lanfumey, Rui Daniel Prediger, Julia Elisa Sepulveda-Diaz et al. · 2015 · Neurotoxicity Research
Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases
Rebecca Ferrisi, Costanza Ceni, Simone Bertini, Marco Macchia, Clementina Manera, Francesca Gado · 2021 · Pharmacological Research
Pathways of neurodegeneration and experimental models of basal ganglia disorders: Downstream effects of mitochondrial inhibition
Massimiliano Di Filippo, Barbara Picconi, Cinzia Costa, Vincenza Bagetta, Michela Tantucci, Lucilla Parnetti, Paolo Calabresi · 2006 · European Journal of Pharmacology
Evaluation of Nigrostriatal Neurodegeneration and Neuroinflammation Following Repeated Intranasal 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration in Mice, an Experimental Model of Parkinson’s Disease
Fabrine Sales Massafera Tristão, Majid Amar, Ines Latrous, Elaine Aparecida Del Bel, Rui Daniel Prediger, Rita Raisman‐Vozari · 2013 · Neurotoxicity Research
The peroxisome proliferator‐activated receptor‐γ agonist 1,1‐bis(3′‐indolyl)‐1‐(p‐trifluoromethylphenyl)methane suppresses manganese‐induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells
Ronald B. Tjalkens, Xuhong Liu, Brianne Mohl, Tyler T. Wright, Julie A. Moreno, David L. Carbone, Stephen H Safe · 2007 · Journal of Neuroscience Research
Role of Formyl Peptide Receptors (FPR) in Abnormal Inflammation Responses Involved in Neurodegenerative Diseases
Adriano Mollica, Azzurra Stefanucci, Roberto Costante, Francesco Pinnen · 2012 · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry