Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, Gabriel T., Jackson-Lewis, Vernice, Vukosavic, Slobodanka, Mandir, Allen S., Vila, Miquel, McAuliffe, W. Geoffrey, Dawson, Valina L., Dawson, Ted M. +1 more·1999·Nature Medicine

DOI 10.1038/70978

Cited by (1,000)

Items 401–500 of 1,000

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Kimberly C. Paul, Janet S. Sinsheimer, Shannon L. Rhodes, Myles Cockburn, Jeff M. Bronstein, Beate R. Ritz · 2015 · Environmental Health Perspectives
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Mustafa Taleb Ardah, Greeshma Bharathan, Tohru Kitada, M. Emdadul Haque · 2020 · Biomolecules
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S. D. Hurley, M. O'Banion, David D. Song, F. S. Arana, J. Olschowka, S. Haber · 2003 · Experimental Neurology
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Lichuan Yang, Noel Ylagan Calingasan, Beverly J. Lorenzo, M. Flint Beal · 2007 · Experimental Neurology
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Junji Ichikawa, Daisuke Tsuchimoto, Sugako Oka, Mizuki Ohno, Masato Furuichi, Kunihiko Sakumi, Yusaku Nakabeppu · 2007 · DNA repair
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Elaine Aparecida Del Bel, Mariza Bortolanza, Maurício dos Santos Pereira, Keila Bariotto‐dos‐Santos, Rita Raisman‐Vozari · 2016 · Synapse
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Concepción García, María Gómez‐Cañas, Sonia Burgaz, Belén Palomares, Yolanda Gómez‐Gálvez, Cristina Palomo‐Garo, Sara Campo, Joel Ferrer-Hernández, Carolina Pavicic, Carmen M. Navarrete et al. · 2018 · Journal of Neuroinflammation
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Zhu, Junge, Gao, Wenming, Shan, Xuehua, Wang, Chunmei, Wang, Huiqing, Shao, Ziqi, Dou, Shanshan, Jiang, Yunlu, Wang, Chuangong, Cheng, Baohua · 2020 · Brain Research
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Tomohiro Nakamura, Stuart A. Lipton · 2019 · Antioxidants and Redox Signaling
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María A. Mena, Sonsoles de Bernardo, Marı́a José Casarejos, Santiago Canals, Eulalia Rodríguez‐Martín · 2002 · Molecular Neurobiology
Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells
Kohichi Kawahara, Tomomi Gotoh, Seiichi Oyadomari, Makoto Kajizono, Akihiko Kuniyasu, Keiko Ohsawa, Yoshinori Imai, Shinichi Kohsaka, Hitoshi Nakayama, Masataka Mori · 2001 · Molecular Brain Research
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Marina Yamada, Kotaro Kida, Willington Amutuhaire, Fumito Ichinose, Masao Kaneki · 2010 · Biochemical and Biophysical Research Communications
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Israr Ahmad, Ashutosh Kumar, Smriti Shukla, Haushila Prasad Pandey, Chetna Singh · 2008 · Free Radical Research
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Thomas Taetzsch, Michelle L. Block · 2013 · Journal of Biochemical and Molecular Toxicology
Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration
Christine V. Fontanilla, Zhizhong Ma, X. Wei, Jens Klotsche, Liming Zhao, Paul Wisniowski, Richard C. Dodel, Martin Rhys Farlow, Wolfgang Hermann Oertel, Yansheng Du · 2011 · Neuroscience
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Thomas, Madhavi, Le, Wei Dong, Jankovic, Joseph · 2003 · Clinical Neuropharmacology
Mapping neuroinflammation in frontotemporal dementia with molecular PET imaging
Zhang, Jing · 2015 · Journal of Neuroinflammation
Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder
Hui Zhang, Álex Iranzo, Birgit Högl, Isabelle Arnulf, Luigi Ferini‐Strambi, Raffaele Manni, Tomoyuki Miyamoto, Wolfgang Hermann Oertel, Yves A Dauvilliers, Yo‐El S. Ju et al. · 2022 · Annals of Neurology
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Adalberto Alves de Castro, Bárbara Paula Wiemes, Filipe Carvalho MATHEUS, Fernanda da Rocha Lapa, Giordano Gübert Viola, Adair R.S. Santos, Carla I. Tasca, Rui Daniel Prediger · 2013 · Brain Research
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Sam V. Kaplan, Ryan Limbocker, Rachel C. Gehringer, Jenny L. Divis, Gregory L. Osterhaus, Maxwell D. Newby, Michael J. Sofis, David P. Jarmolowicz, Brooke D. Newman, Tiffany A. Mathews et al. · 2016 · ACS Chemical Neuroscience
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Jae Kyu Ryu, Won H. Shin, Jean Kim, Eun H. Joe, Yong B. Lee, Kyung G. Cho, Young J. Oh, Seung Up Kim, Byung Kwan Jin · 2002 · Glia
Protective action of neuronal nitric oxide synthase inhibitor in the MPTP mouse model of Parkinson’s disease
Yu Watanabe, Hiroyuki Kato, Tsutomu Araki · 2007 · Metabolic Brain Disease
Neuroprotective Actions of Coenzyme Q10 in Parkinson's Disease
S Sharma, M Kheradpezhou, S Shavali, Hesham El Refaey, Josh Eken, C Hagen, Manuchair Ebadi · 2004 · Methods in enzymology on CD-ROM/Methods in enzymology
Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinsons Disease
Randy L. Hunter, Guoying Bing · 2007 · Current Neuropharmacology
Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases
Tomohiro Nakamura, Stuart A. Lipton · 2007 · Cellular and Molecular Life Sciences
Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice
Gunjan Dhawan Manocha, Angela Marie Floden, Kendra L. Puig, Kumi Nagamoto‐Combs, Clemens R. Scherzer, Colin Kelly Combs · 2017 · Molecular Neurodegeneration
Antisense Oligodeoxynucleotide to Inducible Nitric Oxide Synthase Protects against Transient Focal Cerebral Ischemia—Induced Brain Injury
Sophie Parmentier‐Batteur, Georg Andrees Böhme, Dominique Lerouet, Li Zhou-Ding, Virginie Beray‐Berthat, Isabelle Margaill, Michel Plotkine · 2001 · Journal of Cerebral Blood Flow & Metabolism
Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
Francesca L’Episcopo, Cataldo Tirolo, Salvatore Caniglia, Nunzio Testa, Pier Andrea Serra, Francesco Impagnatiello, Maria C. Morale, Bianca Marchetti · 2010 · Journal of Neuroinflammation
Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease
Tuan Hoang, Dong‐Kug Choi, Makiko Nagai, Du Chu Wu, Tetsuya Nagata, Delphine Prou, Glenn L. Wilson, Miquel Vila, Vernice R. Jackson-Lewis, Valina Lynn Dawson et al. · 2009 · Free Radical Biology and Medicine
Castration Induces Parkinson Disease Pathologies in Young Male Mice via Inducible Nitric-oxide Synthase
Saurabh Khasnavis, Anamitra Ghosh, Avik Roy, Kalipada Pahan · 2013 · Journal of Biological Chemistry
A Microchip‐Based System for Immobilizing PC 12 Cells and Amperometrically Detecting Catecholamines Released After Stimulation with Calcium
Michelle W. Li, Dana M. Spence, R. Scott Martin · 2005 · Electroanalysis
Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice.
Wanida Tripanichkul, Jaroensuppaperch Eo · 2013 · PubMed
Nitric oxide mediates glial-induced neurodegeneration in Alexander disease
Liqun Wang, Tracy L. Hagemann, Hermann Kalwa, Thomas M. Michel, Albee Messing, Mel Β. Feany · 2015 · Nature Communications
Impaired CBS-H2S signaling axis contributes to MPTP-induced neurodegeneration in a mouse model of Parkinson’s disease
Yuqing Yuan, Yali Wang, Baoshi Yuan, Xin Yuan, Xiao‐Ou Hou, Jin‐Song Bian, Chun‐Feng Liu, Li‐Fang Hu · 2017 · Brain Behavior and Immunity
Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats
Martine Saint‐Pierre, Marie‐Ève Tremblay, Attila Gabor SIK, Robert E. Gross, Francesca Cicchetti · 2006 · Journal of Neurochemistry
Age- and sex-differences in the nitric oxide synthase expression and dopamine concentration in the murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Ilona Joniec‐Maciejak, Agnieszka Ciesielska, Iwona Kurkowska‐Jastrzębska, Adam M. Przybyłkowski, Anna Członkowska, Andrzej Członkowski · 2009 · Brain Research
Glucocorticoid receptor–nitric oxide crosstalk and vulnerability to experimental parkinsonism: pivotal role for glia–neuron interactions
Bianca Marchetti, Pier Andrea Serra, Cataldo Tirolo, Francesca L’Episcopo, Salvatore Caniglia, Florinda Gennuso, Nunzio Testa, EGIDIO MIELE, Speranza Desole, Nicholas Barden et al. · 2005 · Brain Research Reviews
Developmental Exposure to Manganese Increases Adult Susceptibility to Inflammatory Activation of Glia and Neuronal Protein Nitration
Julie A. Moreno, Karin M. Streifel, Kelly A. Sullivan, Marie E. Legare, Ronald B. Tjalkens · 2009 · Toxicological Sciences
Apoptosis‐inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins
Céline Perier, Jordi Bové, Benjamin Dehay, Vernice R. Jackson-Lewis, Peter S. Rabinovitch, Serge Przedborski, Miquel Vila · 2010 · Annals of Neurology
Neuroinflammation and Parkinson's disease.
S. Przedborski · 2007 · Handbook of Clinical Neurology
Intranigral infusion of interleukin‐1β activates astrocytes and protects from subsequent 6‐hydroxydopamine neurotoxicity
Josep Saura, Mireia Parés, Jordi Bové, Susana Pezzi, Jordi Alberch, Concepció Marı́n, EDUARDO S. TOLOSA, Marı́a José Martı́ · 2003 · Journal of Neurochemistry
Nitric oxide, glial cells and neuronal degeneration in parkinsonism
Étienne C. Hirsch, Stéphane Hunot · 2000 · Trends in Pharmacological Sciences
Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson’s disease model
Xiaofei Qiu, Qinghui Wang, Liyan Hou, Cuili Zhang, Qingshan Wang, Xiulan Zhao · 2021 · Toxicology Letters
Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases
Qingshan Wang, Chun‐Hsien Chu, Esteban A. Oyarzabal, Lulu Jiang, Shih‐Heng Chen, Belinda C. Wilson, Qian Li, Jau‐Shyong Hong · 2014 · Glia
Mitochondrial Permeability Transition Pore Component Cyclophilin D Distinguishes Nigrostriatal Dopaminergic Death Paradigms in the MPTP Mouse Model of Parkinson's Disease
Bobby Thomas, Rebecca Banerjee, Natalia N. Starkova, Steven F. Zhang, Noel Ylagan Calingasan, Lichuan Yang, Elizabeth J. Wille, Beverly J. Lorenzo, Daniel J. Ho, M. Flint Beal et al. · 2011 · Antioxidants and Redox Signaling
Neuroprotection by marine-derived compound, 11-dehydrosinulariolide, in an in vitro Parkinson’s model: a promising candidate for the treatment of Parkinson’s disease
Wu-Fu Chen, Chiranjib Chakraborty, Chun‐Sung Sung, Chien‐Wei Feng, Yen‐Hsuan Jean, Yen‐You Lin, Han-Chun Hung, Tzu-Yi Huang, Shiying Huang, Thung-Ming Su et al. · 2011 · Naunyn-Schmiedeberg s Archives of Pharmacology
Role of glial cells in neurotoxin-induced animal models of Parkinson’s disease
Hironori Yokoyama, Hiroto Uchida, Hayato Kuroiwa, Jiro Kasahara, Tsutomu Araki · 2010 · Neurological Sciences
Growth/differentiation factor-15 deficiency compromises dopaminergic neuron survival and microglial response in the 6-hydroxydopamine mouse model of Parkinson's disease
Venissa Machado, Stefan Jean-Pierre Haas, Oliver von Bohlen und Halbach, Andreas Wree, Kerstin G. KRIEGLSTEIN, Klaus Unsicker, Björn Spittau · 2015 · Neurobiology of Disease
Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson's disease
Yun‐Long Zhang, Yan Liu, Xin-Pan Kang, Chun-Yan Dou, Rengong Zhuo, Shuqiong Huang, Li Peng, Lei Wen · 2017 · Neuropharmacology
Phenothiazine normalizes the NADH/NAD+ ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinson's disease
Vı́ctor Tapias, Jennifer L. McCoy, J. Timothy Greenamyre · 2019 · Redox Biology
Nitric Oxide Mimetic Molecules as Therapeutic Agents in Alzheimers Disease
Gregory R. J. Thatcher, Brian M. Bennett, James N. Reynolds · 2005 · Current Alzheimer Research
An Investigation of the Neuroprotective Effects of Tetracycline Derivatives in Experimental Models of Retinal Cell Death
Baptiste, Darryl C, Hartwick, Andrew T. E, Jollimore, Christine A. B, Baldridge, William H, Seigel, Gail M, Kelly, Melanie E. M · 2004 · Molecular Pharmacology
Dysregulation of tyrosinase activity: a potential link between skin disorders and neurodegeneration
Wanli Jin, Samantha J. Stehbens, Ross Thomas Barnard, Mark A. T. Blaskovich, Zyta Maria Ziora · 2023 · Journal of Pharmacy and Pharmacology
Neuroprotective strategies in parkinson’s disease: protection against progressive nigral damage induced by free radicals
Chuang C. Chiueh, Tsugunobu Andoh, Andrew Ryan Lai, Edgar Lai, Gopal A. Krishna · 2000 · Neurotoxicity Research
Bone marrow-derived mesenchymal stem cells modulate BV2 microglia responses to lipopolysaccharide
Yin Yin Ooi, Rajesh Ramasamy, Zul'atfi Rahmat, Hemavathy Subramaiam, Shi Wei Tan, Maha Abdullah, Daud Ahmad Israf, Sharmili Vidyadaran · 2010 · International Immunopharmacology
Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool
Benoı̂t Chénais, Hamid Morjani, Jean‐Claude Drapier · 2002 · Journal of Neurochemistry