The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
Abstract
We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in the CA1 region. CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories. Surprisingly, these deficits could be rescued by enriching experience. Using stereological electron microscopy, we found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates. Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“mice with selective NMDA-R subunit 1 knockout in the hippocampal CA1 area exhibited NOP deficits”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Rampon et al., 2000
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
Scoville, W. B., & Milner, B. (1957) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.20.1.11 · Cited by 7,322
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258
The unbiased estimation of number and sizes of arbitrary particles using the disector
Sterio, D. C. (1984) · Journal of Microscopy · doi:10.1111/j.1365-2818.1984.tb02501.x · Cited by 2,533
Zola-Morgan, S., Squire, L., & Amaral, D. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02950.1986 · Cited by 1,997
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,878
Self-citationThe essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Greenough, W. T., Withers, G. S. & Wallace, C. S. in The Biology of Memory (eds. Squire, L. R. & Lindenbaum, E.) 159–185 (Schattauer, Stuttgart, 1990).
- Gray, E. G. Axosomatic and axodendritic synapses of the cerebral cortex: An electron microscopic study. J. Anat. 83, 420– 433 (1959).
Cited by
Sorted by citations
Items 201–300 of 734
Tatard-Leitman, V. M., Jutzeler, C. R., Suh, J., Saunders, J. A., Billingslea, E. N., Morita, S., White, R. S., Featherstone, R. E., Ray, R., Ortinski, P. I., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.06.026 · Cited by 98
Sui, L., Wang, Y., Ju, L.-H., & Chen, M. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.03.007 · Cited by 109
Kulesskaya, N., Rauvala, H., & Võikar, V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024755 · Cited by 105
Araya, R., Noguchi, T., Yuhki, M., Kitamura, N., Higuchi, M., Saido, T. C., Seki, K., Itohara, S., Kawano, M., Tanemura, K., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.07.010 · Cited by 98
Experimental and clinical findings from physical exercise as complementary therapy for epilepsy
Arida, R. M., de Almeida, A.-C. G., Cavalheiro, É. A., & Scorza, F. A. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.07.025 · Cited by 98
Prediger, R. D., Fernandes, D., & Takahashi, R. N. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.10.017 · Cited by 99
Mechanism for long-term memory formation when synaptic strengthening is impaired
Radwanska, K., Medvedev, N. I., Pereira, G. S., Engmann, O., Thiede, N., Moraes, M. F. D., Villers, A., Irvine, E. E., Maunganidze, N. S., Pyza, E. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109680108 · Cited by 97
Social Ecology of Children’s Vulnerability to Environmental Pollutants
Weiss, B., & Bellinger, D. C. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.9101 · Cited by 96
Rosa, R. M., Flores, D. G., Appelt, H. R., Braga, A. L., Henriques, J. A. P., & Roesler, R. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00187-3 · Cited by 94
Abramov, U., Puussaar, T., Raud, S., Kurrikoff, K., & Vasar, E. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.07.075 · Cited by 95
Adult-born neurons modify excitatory synaptic transmission to existing neurons
Adlaf, E. W., Vaden, R. J., Niver, A. J., Manuel, A. F., Onyilo, V. C., Araujo, M. T., Dieni, C. V., Vo, H. T., King, G. D., Wadiche, J. I., et al. (2017) · eLife · doi:10.7554/elife.19886 · Cited by 93
Adult neurogenesis is functionally associated with AD-like neurodegeneration
Chen, Q., Nakajima, A., Choi, S. H., Xiong, X., Sisodia, S. S., & Tang, Y. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.09.005 · Cited by 94
Self-citationDewachter, I., Ris, L., Jaworski, T., Seymour, C. M., Kremer, A., Borghgraef, P., Vijver, H. D., Godaux, E., & LEUVEN, F. V. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.04.003 · Cited by 94
Transformation of cortical and hippocampal neural circuit by environmental enrichment
Hirase, H., & Shinohara, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.031 · Cited by 96
Nagel, B. J., Palmer, S. L., Reddick, W. E., Glass, J. O., Helton, K. J., Wu, S., Xiong, X., Kun, L. E., Gajjar, A. J., & Mulhern, R. K. (2004) · PubMed Central · Cited by 90
Rondi‐Reig, L., Libbey, M., Eichenbaum, H., & Tonegawa, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041620798 · Cited by 92
Hutchinson, K. M., McLaughlin, K. J., Wright, R. L., Ortiz, J. B., Anouti, D. P., Mika, A., Diamond, D. M., & Conrad, C. D. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.01.003 · Cited by 93
Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour
Tanimura, Y., Yang, M. C. K., & Lewis, M. H. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.01.001 · Cited by 91
Lee, E. H. Y., Hsu, W., Ma, Y., Lee, P. J., & Chao, C.-C. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03032.x · Cited by 91
Malik, R., & Chattarji, S. (2011) · Journal of Neurophysiology · doi:10.1152/jn.01009.2011 · Cited by 96
Nishiyama, H., Fukaya, M., Watanabe, M., & Linden, D. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.010 · Cited by 88
Broad activation of the olfactory bulb produces long-lasting changes in odor perception
Mandairon, N., Stack, C. M., Kiselycznyk, C., & Linster, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602750103 · Cited by 89
Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Saido, T. C., Hopwood, J. J., & Sargeant, T. J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.006 · Cited by 88
Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice
Verret, L., Krezymon, A., Halley, H., Trouche, S. G., Zerwas, M., Lazouret, M., Lassalle, J., & Rampon, C. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.05.013 · Cited by 87
Self-citationNatural variation in learning and memory
Mery, F. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.09.001 · Cited by 87
Terry, A. V., Kutiyanawalla, A., & Pillai, A. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.11.005 · Cited by 88
Wang, A., Nie, W., Li, H., Hou, Y.-H., Yu, Z., Fan, Q., & Sun, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094394 · Cited by 85
Zai, L. J., Ferrari, C., Dice, C., Subbaiah, S., Havton, L. A., Coppola, G., Geschwind, D. H., Irwin, N., Huebner, E. A., Strittmatter, S. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4498-10.2011 · Cited by 82
Layer and regional effects of environmental enrichment on the pyramidal neuron morphology of the rat
Gelfo, F., Bartolo, P. D., Giovine, A., Petrosini, L., & Leggio, M. G. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.01.010 · Cited by 85
Excitation–transcription coupling, neuronal gene expression and synaptic plasticity
Ma, H., Khaled, H. G., Wang, X., Mandelberg, N. J., Cohen, S. M., He, X., & Tsien, R. W. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00742-5 · Cited by 84
Long-lasting and transgenerational effects of an environmental enrichment on memory formation
Arai, J. A., & Feig, L. A. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.11.003 · Cited by 87
Advanced behavioural screening: automated home cage ethology
Spruijt, B. M., & de Visser, L. (2006) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2006.06.010 · Cited by 87
Hardt, O. M., Nader, K., & Wang, Y.-T. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0141 · Cited by 89
Collombet, J. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.003 · Cited by 83
Novaes, L. S., dos Santos, N. B., Batalhote, R. F. P. F., Malta, M. B., Camarini, R., Scavone, C., & Munhoz, C. D. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.026 · Cited by 81
Refinement of rodent research through environmental enrichment and systematic randomization
Würbel, H., & Garner, J. P. (2007) · Cited by 81
Modification of AMPA receptor properties following environmental enrichment
Naka, F., Narita, N., Okado, N., & Narita, M. (2004) · Brain and Development · doi:10.1016/j.braindev.2004.07.006 · Cited by 81
Lü, W., Bushong, E. A., Shih, T., Ellisman, M. H., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.030 · Cited by 79
Martínez‐Cué, C., Rueda, N., García, E., Davisson, M. T., Schmidt, C., & Flórez, J. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.04.016 · Cited by 83
McEchron, M. D., Cheng, A. Y. T., Liu, H., Connor, J. R., & Gilmartin, M. R. (2005) · Nutritional Neuroscience · doi:10.1080/10284150500162952 · Cited by 79
Leuba, G., Walzer, C., Vernay, A., Carnal, B., Kraftsik, R., Piotton, F., Marin, P., Bouras, C., & Savioz, A. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.02.012 · Cited by 83
Pamplona, F. A., Pandolfo, P., Savoldi, R., Prediger, R. D., & Takahashi, R. N. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.06.012 · Cited by 82
Hippocampus‐dependent learning is associated with adult neurogenesis in MRL/MpJ mice
Thuret, S., Toni, N., Aigner, S., Yeo, G. W.-M., & Gage, F. H. (2009) · Hippocampus · doi:10.1002/hipo.20550 · Cited by 79
Hüttenrauch, M., Brauß, A., Kurdakova, A., Borgers, H., Klinker, F., Liebetanz, D., Salinas-Riester, G., Wiltfang, J., Klafki, H. W., & Wirths, O. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.65 · Cited by 78
“45,46 We demonstrate for the fi rst time that 12-month-old Tg4-42 het mice show impaired recognition memory, which can be completely rescued using EE housing conditions.”
Neurone specific regulation of dendritic spines in vivo by post synaptic density 95 protein (PSD-95)
Vickers, C. A., Stephens, B., Bowen, J., Arbuthnott, G. W., Grant, S. G. N., & Ingham, C. A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.075 · Cited by 80
Behavioural phenotyping of mouse mutants
van der Staay, F. J., & Steckler, T. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00278-9 · Cited by 78
Kishimoto, Y., Fujimichi, R., Araishi, K., Kawahara, S., Kano, M., Aiba, A., & Kirino, Y. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02407.x · Cited by 78
Gresack, J., Kerr, K. M., & Frick, K. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.07.015 · Cited by 81
Hendriksen, H., Prins, J., Olivier, B., & Oosting, R. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011943 · Cited by 78
Ramsey, A., Milenkovic, M., Oliveira, A. F., Escobedo-Lozoya, Y., Seshadri, S., Salahpour, A., Sawa, A., Yasuda, R., & Caron, M. (2011) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1012621108 · Cited by 83
Environmental enrichment reduces the mnemonic and neural benefits of estrogen
Gresack, J. E., & Frick, K. M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.011 · Cited by 74
Bindu, B., Alladi, P. A., Mansooralikhan, B. M., Srikumar, B. N., Raju, T. R., & Kutty, B. M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.057 · Cited by 80
Adrenergic enhancement of consolidation of object recognition memory
Dornelles, A. D. S., de Lima, M. N. M., Grazziotin, M. M., Presti-Torres, J., Garcia, V. A., Scalco, F. S., Roesler, R., & Schröder, N. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.01.005 · Cited by 74
Mahati, K., Bhagya, V. R., Christofer, T., Sneha, A., & Rao, B. S. S. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.017 · Cited by 80
Editorial: Genetics of Brain Function and Cognition
de Geus, E. J. C., Wright, M. J., Martin, N. G., & Boomsma, D. I. (2001) · Behavior Genetics · doi:10.1023/a:1013360909048 · Cited by 76
Eckert, M. J., & Abraham, W. C. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_215 · Cited by 74
Hippocampal c-fos is necessary for long-term memory of a socially transmitted food preference
Countryman, R. A., Kaban, N. L., & Colombo, P. J. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.07.005 · Cited by 73
Blázquez, G., Cañete, T., Tobeña, A., Giménez‐Llort, L., & Fernández‐Teruel, A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.008 · Cited by 81
Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway
Guan, J., Su, S. C., Gao, J., Joseph, N. F., Xie, Z., Zhou, Y., Durak, O., Zhang, L., Zhu, J., Clauser, K. R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025735 · Cited by 73
Ethological concepts enhance the translational value of animal models
Peters, S. M., Pothuizen, H. H. J., & Spruijt, B. M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.043 · Cited by 70
Systems consolidation and the content of memory
Wiltgen, B. J., & Tanaka, K. Z. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.06.001 · Cited by 78
A brain adaptation view of plasticity: is synaptic plasticity an overly limited concept?
Grossman, A. W., Churchill, J. D., Bates, K. E., Kleim, J. A., & Greenough, W. T. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)38073-7 · Cited by 71
Test, rinse, repeat: A review of carryover effects in rodent behavioral assays
Cnops, V., Iyer, V. R., Parathy, N., Wong, P., & Dawe, G. S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104560 · Cited by 79
An animal model of recognition memory and medial temporal lobe amnesia: History and current issues
Clark, R. E., & Squire, L. R. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.02.004 · Cited by 68
Burman, M. A., Starr, M. J., & Gewirtz, J. C. (2005) · Hippocampus · doi:10.1002/hipo.20137 · Cited by 69
Toki, S., Morinobu, S., Imanaka, A., Yamamoto, S., Yamawaki, S., & Honma, K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05288.x · Cited by 69
Anterior thalamic nuclei lesions and recovery of function: Relevance to cognitive thalamus
Dalrymple‐Alford, J. C., Harland, B. C., Loukavenko, E. A., Perry, B. A. L., Mercer, S. A., Collings, D. A., Ulrich, K., Abraham, W. C., McNaughton, N., & Wolff, M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.007 · Cited by 75
Steadman, C. R., & Allan, A. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073720 · Cited by 70
Mainardi, M., Landi, S., Gianfranceschi, L., Baldini, S., Pasquale, R. D., Berardi, N., Maffei, L., & Caleo, M. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22461 · Cited by 73
Jobim, P. F. C., Pedroso, T. R., Werenicz, A., Christoff, R. R., Maurmann, N., Reolon, G. K., Schröder, N., & Roesler, R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.004 · Cited by 68
PARK, P. J., & Bell, M. A. (2010) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2010.01987.x · Cited by 68
Rapid plasticity of dendritic spine: hints to possible functions?
Segal, M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00021-6 · Cited by 68
Kudo, K., Qiao, C.-X., Kanba, S., & Arita, J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.08.007 · Cited by 71
Li, G., Gan, Y., Fan, Y., Wu, Y., Lin, H., Song, Y., Cai, X., Yu, X., Pan, W., Yao, M., et al. (2015) · Scientific Reports · doi:10.1038/srep07856 · Cited by 67
Inducible and Selective Erasure of Memories in the Mouse Brain via Chemical-Genetic Manipulation
Cao, X., Wang, H., Mei, B., An, S., Yin, L., Wang, L. P., & Tsien, J. Z. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.027 · Cited by 69
Self-citationSupervisory experience at work is linked to low rate of hippocampal atrophy in late life
Suo, C., León, I., Brodaty, H., Trollor, J. N., Wen, W. X., Sachdev, P. S., & Valenzuela, M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.08.015 · Cited by 73
Bahí, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.001 · Cited by 65
Environmental enrichment: effects on stereotyped behavior and regional neuronal metabolic activity
Turner, C. A., Yang, M. C. K., & Lewis, M. H. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02472-1 · Cited by 65
Bohacek, J., & Daniel, J. M. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.04.010 · Cited by 68
Molecular Characterization of NMDA-Like Receptors inAplysiaandLymnaea:Relevance to Memory Mechanisms
Ha, T. J., Kohn, A. B., Bobkova, Y. V., & Moroz, L. L. (2006) · Biological Bulletin · doi:10.2307/4134562 · Cited by 65
Hippocampal c-Jun-N-Terminal Kinases Serve as Negative Regulators of Associative Learning
Sherrin, T., Blank, T., Hippel, C., Rayner, M. D., Davis, R. J., & Todorovic, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3492-10.2010 · Cited by 67
Sex differences in object recognition are modulated by object similarity
Bettis, T. J., & Jacobs, L. F. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.028 · Cited by 64
Nebeling, F. C., Poll, S., Justus, L. C., Mittag, M., Steffen, J., Keppler, K., & Fuhrmann, M. (2023) · eLife · doi:10.7554/elife.83176 · Cited by 67
Negative Neuroplasticity in Chronic Traumatic Brain Injury and Implications for Neurorehabilitation
Tomaszczyk, J. C., Green, N. L., Frasca, D., Colella, B., Turner, G. R., Christensen, B. K., & Green, R. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9273-6 · Cited by 71
Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation
Barichello, T., Martins, M. R., Reinke, A., Constantino, L. D. S., Machado, R. A., Valvassori, S. S., Moreira, J. C. F., Quevedo, J., & Dal‐Pizzol, F. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2007000600013 · Cited by 63
Sy, H., Wu, S., Wang, W., Chen, C.-H., Huang, Y.-T., Liou, Y., Chiou, C., Pawlak, C. R., & Ho, Y. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.12.020 · Cited by 63
Characterization of NMDAR-Independent Learning in the Hippocampus
Tayler, K. K., Lowry, E., Tanaka, K. Z., Levy, B., Reijmers, L. G. J. E., Mayford, M. R., & Wiltgen, B. J. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00028 · Cited by 61
Zeleznikow-Johnston, A., Burrows, E. L., Renoir, T., & Hannan, A. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.009 · Cited by 60
Chapter 2.2 Animal episodic memory
Dere, E., Zlomuzica, A., Huston, J. P., & Silva, M. A. D. S. (2008) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(08)00210-5 · Cited by 61
Seo, J. H., Yu, J. H., Suh, H., Kim, M., & Cho, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074405 · Cited by 60
Hadley, C., Hadley, B., Ephraim, S., Yang, M. C. K., & Lewis, M. H. (2005) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2005.08.006 · Cited by 60
Implications of animal object memory research for human amnesia
Winters, B. D., Saksida, L. M., & Bussey, T. J. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.01.023 · Cited by 63
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits
Woronowicz, A., Koshimizu, H., Chang, S., Cawley, N. X., Hill, J. M., Rodriguiz, R. M., Abebe, D. T., Dorfman, C. S., Senatorov, V. V., Zhou, A., et al. (2008) · Hippocampus · doi:10.1002/hipo.20462 · Cited by 60
Environmental Enrichment Provides a Cognitive Reserve to be Spent in the Case of Brain Lesion
Mandolesi, L., Bartolo, P. D., Foti, F., Gelfo, F., Federico, F., Leggio, M. G., & Petrosini, L. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15102 · Cited by 60
Cao, T., Zhou, X., Zheng, X., Cui, Y., Tsien, J. Z., Li, C., & Wang, H. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00137 · Cited by 62
Self-citationEnvironmental enrichment as an experience-dependent modulator of social plasticity and cognition
Gubert, C., & Hannan, A. J. (2019) · Brain Research · doi:10.1016/j.brainres.2019.03.033 · Cited by 61
Barbelivien, A., Herbeaux, K., Oberling, P., Kelche, C. R., Galani, R., & Majchrzak, M. J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.01.012 · Cited by 59
Influence of environmental manipulation on exploratory behaviour in male BDNF knockout mice
Zhu, S., Codita, A., Bogdanović, N., Hjerling‐Leffler, J., Ernfors, P., Winblad, B. G., Dickins, D. W., & Mohammed, A. H. S. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.032 · Cited by 58
Zhu, X., Wang, F., Hu, H., Sun, X., Kilgard, M. P., Merzenich, M. M., & Zhou, X. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5310-13.2014 · Cited by 59
Sabariego, M., Schonwald, A., Boublil, B. L., Zimmerman, D. T., Ahmadi, S., Gonzalez, N., Leibold, C., Clark, R. E., Leutgeb, J. K., & Leutgeb, S. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.005 · Cited by 60
Metadata
- Authors
- Rampon, C., Tang, Y.-P., Goodhouse, J., Shimizu, E., Kyin, M., & Tsien, J. Z.
- Affiliations
- Princeton University (US)
- Corresponding author
- Tsien, Joe Z.
- Venue
- Nature Neuroscience
- Published
- 2000-03-01
- Volume
- 3
- Issue
- 3
- Pages
- 238-244
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1481984979
- Semantic Scholar
- fa40536e2cbc3bd383f248197b5f4cb17804cd65
- Cited by
- 755
- References
- 41
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 20 · 2022: 12 · 2021: 16 · 2020: 20 · 2019: 20 · 2018: 22 · 2017: 22 · 2016: 32 · 2015: 30 · 2014: 33 · 2013: 40 · 2012: 44
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for the National Institutes of Health
- Arnold and Mabel Beckman Foundation
- Princeton University
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- NMDA receptor 1, CA1, hippocampus, memory impairment, object recognition memory, odor discrimination, contextual fear memory, environmental enrichment, synaptic plasticity, synaptic density, knockout mice, memory recovery
- MeSH terms
- Animals, Conditioning, Psychological, Cues, Dendrites, Electroshock, Exploratory Behavior, Fear, Female, Food Preferences, Male, Memory, Memory Disorders, Pattern Recognition, Visual, Smell, Space Perception, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Pyramidal Cells, Mice, Knockout, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review