Cited by 593Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice

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McHugh, Thomas J, Blum, Kenneth I, Tsien, Joe Z, Tonegawa, Susumu, Wilson, Matthew A·1996·Cell

Abstract

To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus, we have applied multiple electrode recording techniques to freely behaving mice with a CA1 pyramidal cell-specific knockout of the NMDAR1 gene. We have discovered that although the CA1 pyramidal cells of these mice retain place-related activity, there is a significant decrease in the spatial specificity of individual place fields. We have also found a striking deficit in the coordinated firing of pairs of neurons tuned to similar spatial locations. Pairs have uncorrelated firing even if their fields overlap. These results demonstrate that NMDA receptor-mediated synaptic plasticity is necessary for the proper representation of space in the CA1 region of the hippocampus.

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Crossref · 10.1016/s0092-8674(00)81828-0

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4 of 4 references verified0 citation errors · 0 not checkable

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  • Genetic deletion of GluN1 in the CA1 region of the hippocampus decreases the spatial specificity of place fields.

    “and the genetic deletion of GluN1 in the CA1 region of the hippocampus decreases the spatial specificity of place fields (420).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [420]

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Authors
McHugh, T. J., Blum, K. I., Tsien, J. Z., Tonegawa, S., & Wilson, M. A.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Massachusetts Institute of Technology (US)
Corresponding author
Tonegawa, Susumu
Venue
Cell
Publisher
Elsevier BV
Published
1996-12
Volume
87
Issue
7
Pages
1339-1349
ISSN
0092-8674 (ISSN-L)
OpenAlex
W1988633143
Cited by
593
References
4
Citations by year
2026: 8 · 2025: 9 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 25 · 2020: 11 · 2019: 16 · 2018: 23 · 2017: 20 · 2016: 19 · 2015: 23 · 2014: 23 · 2013: 19 · 2012: 24
FWCI
17.92
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS-32925, R01NS032925)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
NMDA receptor, CA1 pyramidal neurons, place cells, place fields, spatial representation, synaptic plasticity, freely moving mice
MeSH terms
Action Potentials, Animals, Behavior, Animal, Electrophysiology, Hippocampus, Memory, Neuronal Plasticity, Space Perception, Synapses, Receptors, N-Methyl-D-Aspartate, Mice, Knockout, Maze Learning, Mice

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