CoChat
Sign Up
Cited by 755Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice

Rampon, Claire, Tang, Ya-Ping, Goodhouse, Joe, Shimizu, Eiji, Kyin, Maureen, Tsien, Joe Z.·2000·Nature Neuroscience
DOI 10.1038/72945
Open this paper in CoChat — free account

Abstract

We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in the CA1 region. CA1-KO mice were profoundly impaired in object recognition, olfactory discrimination and contextual fear memories. Surprisingly, these deficits could be rescued by enriching experience. Using stereological electron microscopy, we found that enrichment induced an increase of the synapse density in the CA1 region in knockouts as well as control littermates. Therefore, our data indicate that CA1 NMDA receptor activity is critical in hippocampus-dependent nonspatial memory, but is not essential for experience-induced synaptic structural changes.

Overview

Integrity signals

Registry

Crossref · 10.1038/72945

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 41 references

Research works printed but not linked: 2

  1. Greenough, W. T., Withers, G. S. & Wallace, C. S. in The Biology of Memory (eds. Squire, L. R. & Lindenbaum, E.) 159–185 (Schattauer, Stuttgart, 1990).
  2. Gray, E. G. Axosomatic and axodendritic synapses of the cerebral cortex: An electron microscopic study. J. Anat. 83, 420– 433 (1959).

Cited by

Sorted by citations

See all 755

Related

Metadata

Authors
Rampon, C., Tang, Y.-P., Goodhouse, J., Shimizu, E., Kyin, M., & Tsien, J. Z.
Affiliations
Princeton University (US)
Corresponding author
Tsien, Joe Z.
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2000-03-01
Volume
3
Issue
3
Pages
238-244
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/72945
OpenAlex
W1481984979
Semantic Scholar
fa40536e2cbc3bd383f248197b5f4cb17804cd65
Cited by
755
References
41
Citations by year
2026: 3 · 2025: 8 · 2024: 9 · 2023: 20 · 2022: 12 · 2021: 16 · 2020: 20 · 2019: 20 · 2018: 22 · 2017: 22 · 2016: 32 · 2015: 30 · 2014: 33 · 2013: 40 · 2012: 44
FWCI
15.59
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Foundation for the National Institutes of Health
  • Arnold and Mabel Beckman Foundation
  • Princeton University
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
NMDA receptor 1, CA1, hippocampus, memory impairment, object recognition memory, odor discrimination, contextual fear memory, environmental enrichment, synaptic plasticity, synaptic density, knockout mice, memory recovery
MeSH terms
Animals, Conditioning, Psychological, Cues, Dendrites, Electroshock, Exploratory Behavior, Fear, Female, Food Preferences, Male, Memory, Memory Disorders, Pattern Recognition, Visual, Smell, Space Perception, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Pyramidal Cells, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review