Importance of early lighting conditions in maternal care by dam as well as anxiety and memory later in life of offspring
Open accessAbstract
Rodent studies have revealed that the early rearing environment plays an important role in the development of stress vulnerability, memory and cognition. Although early lighting conditions (ELC) are involved in these neuronal developments through both maternal and offspring behavior, their influence has not been fully elucidated. Thus, by using Sprague‐Dawley rats, we examined whether ELC affected maternal care by the dam and the subsequent neurodevelopment of the offspring. Prolonged dark phase conditions (PDC) (light/dark, 6/18 h) and prolonged light phase conditions (light/dark, 18/6 h) were administered from postnatal day 2 to postnatal day 14. Throughout this period, maternal care and the circadian rhythmicity of dams were investigated. In adolescence and adulthood of the offspring, we measured anxiety‐like behavior, social interaction, object recognition memory, activity rhythm and corticosterone response to stress with hippocampal expression of N‐methyl‐d‐aspartate and glucocorticoid receptor mRNAs. PDC altered maternal care and circadian rhythmicity in the dam compared with normal lighting conditions and prolonged light phase conditions. PDC markedly increased anxiety‐like behavior, decreased social interaction and object recognition memory, and inhibited corticosterone feedback in offspring later in life. Furthermore, hippocampal levels of glucocorticoid receptor mRNA and N‐methyl‐d‐aspartate receptor 2B mRNA in rats subjected to PDC were significantly lower than in animals subjected to normal lighting conditions. In the adult offspring, the circadian rhythm of locomotor activity was not affected. These findings suggested that ELC affect mother–infant interactions and subsequently at least partially alter the neurobehavioral development of offspring.
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As adults, offspring of High LG mothers show more modest plasma ACTH and corticosterone responses to acute stress compared with animals reared by Low LG mothers.
“As adults, the offspring of High LG mothers show more modest plasma ACTH and corticosterone responses to acute stress by comparison to animals reared by Low LG mothers.66,70,71,74,75”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [74]
Variations in pup LG over the first week of postnatal life affect the development of behavioral and HPA responses to stress in adulthood.
“We and other labs find that variations in pup LG over the first week of postnatal life rat affect the development of behavioral and hypothalamic-pituitary-adrenal (HPA) responses to stress in adulthood.66-75”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [74]
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- Authors
- Toki, S., Morinobu, S., Imanaka, A., Yamamoto, S., Yamawaki, S., & Honma, K.
- Affiliations
- Hiroshima University (JP)
- Hokkaido University (JP)
- Corresponding author
- Yamawaki, Shigeto
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2007-02
- Volume
- 25
- Issue
- 3
- Pages
- 815-829
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2124853361
- Cited by
- 69
- References
- 13
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 9
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Hiroshima University Institutional Repository (submittedVersion, other-oa)
- Hiroshima University Acedemic Information Repository (Hiroshima University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- maternal care, circadian rhythmicity, anxiety-like behavior, social interaction, object recognition memory, hippocampus, glucocorticoid receptor, NMDA receptor NR2B, stress vulnerability, mother-infant interaction, brain development
- MeSH terms
- Age Factors, Animals, Anxiety, Circadian Rhythm, Corticosterone, Darkness, Environment, Female, Hippocampus, Lighting, Maternal Behavior, Memory, Motor Activity, Phenotype, Pregnancy, Receptors, Glucocorticoid, RNA, Messenger, Social Behavior, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Rats
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