Cell replacement therapies for central nervous system disorders

The functional anatomy of basal ganglia disorders

Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353

Mammalian neural stem cells.

Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786

A neostriatal habit learning system in humans

Knowlton, B. J., Mangels, J. A., & Squire, L. R. (1996) · Science · doi:10.1126/science.273.5280.1399 · Cited by 1,777

Neuropathological Evidence of Graft Survival and Striatal Reinnervation after the Transplantation of Fetal Mesencephalic Tissue in a Patient with Parkinson's Disease

Kordower, J. H., Freeman, T. B., Snow, B. J., Vingerhoets, F. J. G., Mufson, E. J., Sanberg, P. R., Hauser, R. A., Smith, D. A., Nauert, G. M., Perl, D. P., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504273321702 · Cited by 860

Building neural representations of habits.

Jog, M. S., Kubota, Y., Connolly, C. I., Hillegaart, V., & Graybiel, A. M. (1999) · Science · doi:10.1126/science.286.5445.1745 · Cited by 834

Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

Flax, J. D., Aurora, S., Yang, C., Simonin, C., Wills, A. M., Billinghurst, L. L., Jendoubi, M., Sidman, R. L., Wolfe, J. H., Kim, S. U., et al. (1998) · Nature Biotechnology · doi:10.1038/3473 · Cited by 770

Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

Piccini, P., Brooks, D. J., Björklund, A., Gunn, R. N., Grasby, P. M., Rimoldi, O., Brundin, P., Hagell, P., Rehncrona, S., Widner, H., et al. (1999) · Nature Neuroscience · doi:10.1038/16060 · Cited by 700

Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo

Suhonen, J. O., Peterson, D. A., Ray, J., & Gage, F. H. (1996) · Nature · doi:10.1038/383624a0 · Cited by 622

Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain

Fricker, R. A., Carpenter, M. K., Winkler, C., Greco, C., Gates, M. A., & Björklund, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05990.1999 · Cited by 561

Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats

Studer, L., Tabar, V., & McKay, R. (1998) · Nature Neuroscience · doi:10.1038/1105 · Cited by 529

Progression from Extrinsic to Intrinsic Signaling in Cell Fate Specification

Edlund, T., & Jessell, T. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80561-9 · Cited by 491

Architecture and cell types of the adult subventricular zone: In search of the stem cells

Garc�a-Verdugo, J. M., Doetsch, F., Wichterle, H., Lim, D. A., & Alvarez-Buylla, A. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199808)36:2<234::aid-neu10>3.0.co;2-e · Cited by 486

Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex

Snyder, E. Y., Yoon, C., Flax, J. D., & Macklis, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11663 · Cited by 434

Fetal nigral transplantation as a therapy for Parkinson's disease

Olanow, C. W., Kordower, J. H., & Freeman, T. B. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80038-5 · Cited by 416

Fetal Nigral Transplantation as a Therapy for Parkinson’s Disease

Olanow, C. W., & Fahn, S. (2006) · Restorative Therapies in Parkinson’s Disease · doi:10.1007/0-387-32823-8_6 · Cited by 412

Emerging insights into the genesis of epilepsy

McNamara, J. O. (1999) · Nature · doi:10.1038/399a015 · Cited by 378

Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes

Wagner, J., Åkerud, P., Castro, D. S., Holm, P. C., Canals, J. M., Snyder, E. Y., Perlmann, T., & Arenas, E. (1999) · Nature Biotechnology · doi:10.1038/10862 · Cited by 370

Transplantation of Cryopreserved Human Embryonal Carcinoma-Derived Neurons (NT2N Cells) Promotes Functional Recovery in Ischemic Rats

Borlongan, C. V., Tajima, Y., Trojanowski, J. Q., Lee, V. M.-Y., & Sanberg, P. R. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6730 · Cited by 357

Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease

Kordower, J. H., Freeman, T. B., Chen, E., Mufson, E. J., Sanberg, P. R., Hauser, R. A., Snow, B., & Warren Olanow, C. (1998) · Movement Disorders · doi:10.1002/mds.870130303 · Cited by 298

Differentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines

Ling, Z. D., Potter, E. D., Lipton, J. W., & Carvey, P. M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6715 · Cited by 295

Functional neural transplantation

Rosenfeld, J. V. (1995) · Journal of Clinical Neuroscience · doi:10.1016/0967-5868(95)90062-4 · Cited by 276

Use of Placebo Surgery in Controlled Trials of a Cellular-Based Therapy for Parkinson's Disease

Freeman, T. B., Vawter, D. E., Leaverton, P. E., Godbold, J. H., Hauser, R. A., Goetz, C. G., & Olanow, C. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909233411311 · Cited by 240

Functional neural transplantation

Dunnett, S. B., & Björklund, A. (1994) · Raven Press eBooks · Cited by 239

Dopamine-rich grafts ameliorate whole body motor asymmetry and sensory neglect but not independent limb use in rats with 6-hydroxydopamine lesions

Dunnett, S. B., Whishaw, I. Q., Rogers, D. C., & Jones, G. H. (1987) · Brain Research · doi:10.1016/0006-8993(87)90269-1 · Cited by 232

Anatomy and connectivity of intrastriatal striatal transplants

Wictorin, K. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90044-f · Cited by 187

Recovery of spatial learning by grafts of a conditionally immortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus

Sinden, J. D., Rashid-Doubell, F., Kershaw, T. R., Nelson, A., Chadwick, A., Jat, P. S., Noble, M. D., Hodges, H., & Gray, J. A. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00330-8 · Cited by 177

Host afferents into intrastriatal transplants of fetal ventral mesencephalon

Doucet, G., Murata, Y., Brundin, P., Bosler, O., Mons, N., Geffard, M., Ouimet, C. C., & Björklund, A. (1989) · Experimental Neurology · doi:10.1016/0014-4886(89)90139-8 · Cited by 163

Safety and Tolerability Assessment of Intrastriatal Neural Allografts in Five Patients with Huntington's Disease

Bachoud-Lévi, A.-C., Bourdet, C., Brugières, P., Nguyen, J.-P., Grandmougin, T., Haddad, B., Jény, R., Bartolomeo, P., Boissé, M.-F., Barba, G. D., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7239 · Cited by 159

Dopaminergic transplants in experimental parkinsonism: cellular mechanisms of graft-induced functional recovery

Björklund, A. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90039-n · Cited by 141

Cytokine-induced conversion of mesencephalic-derived progenitor cells into dopamine neurons

Potter, E. D., Ling, Z. D., & Carvey, P. M. (1999) · Cell and Tissue Research · doi:10.1007/s004410051285 · Cited by 140

Intranigral Transplants of GABA-Rich Striatal Tissue Induce Behavioral Recovery in the Rat Parkinson Model and Promote the Effects Obtained by Intrastriatal Dopaminergic Transplants

Winkler, C., Bentlage, C., Nikkhah, G., Samii, M., & Björklund, A. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.6916 · Cited by 117

Neural Grafting to Experimental Neocortical Infarcts Improves Behavioral Outcome and Reduces Thalamic Atrophy in Rats Housed in Enriched but Not in Standard Environments

Mattsson, B., Sørensen, J. C. H., Zimmer, J., & Johansson, B. B. (1997) · Stroke · doi:10.1161/01.str.28.6.1225 · Cited by 109

Electrophysiological characteristics of cells within mesencephalon suspension grafts

Fisher, L. J., Young, S. J., Tepper, J. M., Groves, P. M., & Gage, F. H. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90178-q · Cited by 108

Influence of an Enriched Environment and Cortical Grafting on Functional Outcome in Brain Infarcts of Adult Rats

Grabowski, M., Sørensen, J. C. H., Mattsson, B., Zimmer, J., & Johansson, B. B. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1011 · Cited by 103

Repair of myelin disease: strategies and progress in animal models

Duncan, I. D., Grever, W. E., & Zhang, S. (1997) · Molecular Medicine Today · doi:10.1016/s1357-4310(97)01162-3 · Cited by 94

Cerebral ischemia and CNS transplantation

Borlongan, C. V., Tajima, Y., Trojanowski, J. Q., Lee, V. M. ‐., & Sanberg, P. R. (1998) · Neuroreport · doi:10.1097/00001756-199811160-00025 · Cited by 92

Dopaminergic neural grafts after fifteen years: results and perspectives

Herman, J., & Abrous, D. N. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90055-8 · Cited by 83

Functional repair of striatal systems by neural transplants: evidence for circuit reconstruction

Dunnett, S. B. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(94)00134-2 · Cited by 83

Associative plasticity in striatal transplants

Brasted, P. J., Watts, C., Robbins, T. W., & Dunnett, S. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10524 · Cited by 81

Embryonic Neurons Transplanted to Regions of Targeted Photolytic Cell Death in Adult Mouse Somatosensory Cortex Re-form Specific Callosal Projections

Hernit-Grant, C. S., & Macklis, J. D. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0088 · Cited by 81

Conditionally Immortalized Cell Lines, Engineered to Produce and Release GABA, Modulate the Development of Behavioral Seizures

Thompson, K. W., Anantharam, V., Behrstock, S. P., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7305 · Cited by 80

Contrasting effects of fetal CA1 and CA3 hippocampal grafts on deficits in spatial learning and working memory induced by global cerebral ischaemia in rats

Hodges, H., Sowinski, P., Fleming, P., Kershaw, T. R., Sinden, J. D., Meldrum, B. S., & G, J. A. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00004-8 · Cited by 77

Seizure suppression in kindling epilepsy by intracerebral implants of GABA-but not by noradrenalinereleasing polymer matrices

Kokaia, M., Aebischer, P., Elmér, E., Bengzon, J., Kalén, P., Kokaia, Z., & Lindvall, O. (1994) · Experimental Brain Research · doi:10.1007/bf02738399 · Cited by 67

Conditionally Immortalized Neural Progenitor Cells Grafted to the Striatum Exhibit Site-Specific Neuronal Differentiation and Establish Connections with the Host Globus Pallidus

Lundberg, C., Winkler, C., Whittemore, S. R., & Björklund, A. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0004 · Cited by 63

Selective Hippocampal Lesions Differentially Affect the Phenotypic Fate of Transplanted Neuronal Precursor Cells

Shihabuddin, L. S., Holets, V. R., & Whittemore, S. R. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0081 · Cited by 57

Fetal Neocortical Tissue Blocks Implanted in Brain Infarcts of Adult Rats Interconnect with the Host Brain

Sørensen, J. C. H., Grabowski, M., Zimmer, J., & Johansson, B. B. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0061 · Cited by 56

Specific Reinnervation of Lesioned Mouse Striatum by Grafted Mesencephalic Dopaminergic Neurons

Zuddas, A., Corsini, G. U., Barker, J. L., Kopin, I. J., & di Porzio, U. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00813.x · Cited by 45

Suppression of kindling epileptogenesis in rats by intrahippocampal cholinergic grafts

Ferencz, I., Kokaia, M., Elmér, E., Keep, M. F., Kokaia, Z., & Lindvall, O. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00033.x · Cited by 36

Interleukin-6 is not expressed in activated microglia and in reactive astrocytes in response to lesion of rat basal forebrain cholinergic system as demonstrated by combined in situ hybridization and immunocytochemistry

Lemke, R., H�rtig, W., Ro�ner, S., Bigl, V., & Schliebs, R. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980115)51:2<196::aid-jnr8>3.0.co;2-8 · Cited by 30

Neuronal replacement from endogenous precursors in the adult brain after stroke

Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799

Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease

Kim, J.-H., Auerbach, J. M., Rodríguez-Gómez, J. A., Velasco, I., Gavin, D., Lumelsky, N., Lee, S.-H., Nguyen, J., Sánchez-Pernaute, R., Bankiewicz, K., et al. (2002) · Nature · doi:10.1038/nature00900 · Cited by 1,607

Isolation of multipotent adult stem cells from the dermis of mammalian skin

Toma, J. G., Akhavan, M., Fernandes, K. J. L., Barnabé-Heider, F., Sadikot, A., Kaplan, D. R., & Miller, F. D. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-778 · Cited by 1,593

Cell transplantation therapy for spinal cord injury

Assinck, P., Duncan, G. J., Hilton, B. J., Plemel, J. R., & Tetzlaff, W. (2017) · Nature Neuroscience · doi:10.1038/nn.4541 · Cited by 937

Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery

Li, Y., Chen, J., Chen, X. G., Wang, L., Gautam, S. C., Xu, Y. X., Katakowski, M., Zhang, L. J., Lu, M., Janakiraman, N., et al. (2002) · Neurology · doi:10.1212/wnl.59.4.514 · Cited by 869