Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Lewis, Jada, McGowan, Eileen, Rockwood, Julia, Melrose, Heather, Nacharaju, Parimala, Van Slegtenhorst, Marjon, Gwinn-Hardy, Katrina, Murphy, M. P, Baker, Matt, Yu, Xin, Duff, Karen, Hardy, John, Corral, Anthony, Lin, Wen-Lang, Yen, Shu-Hui, Dickson, Dennis W., Davies, Peter, Hutton, Mike·2000·Nature Genetics
DOI 10.1038/78078

Cited by (121)

Items 101–121 of 121

  1. Activation of PAR-1 Kinase and Stimulation of Tau Phosphorylation by Diverse Signals Require the Tumor Suppressor Protein LKB1
    Wang, Ji-Wu, Imai, Yuzuru, Lu, Bingwei · 2007 · The Journal of Neuroscience
  2. Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model
    Kim, YoungDoo, Choi, Hyunwoo, Lee, WonJae, Park, Hyejin, Kam, Tae-In, Hong, Se-hoon, Nah, Jihoon, Jung, Sunmin, Shin, Bora, Lee, Huikyong et al. · 2016 · Neurobiology of Disease
  3. Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy
    Blackmore, Thomas, Meftah, Soraya, Murray, Tracey Karen, Craig, Peter James, Blockeel, Anthony, Phillips, Keith, Eastwood, Brian, O’Neill, Michael J., Marston, Hugh, Ahmed, Zeshan et al. · 2017 · Alzheimer's Research & Therapy
  4. Central and peripheral circadian clocks and their role in Alzheimer's disease
    Chauhan, Ruchi, Chen, Ko-Fan, Kent, Brianne A., Crowther, Damian C. · 2017 · Disease Models & Mechanisms
  5. Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease.
    Puri, Rajat, Suzuki, Toshimitsu, Yamakawa, Kazuhiro, Ganesh, Subramaniam · 2009 · Journal of Biological Chemistry
  6. Prospects for strain-specific immunotherapy in Alzheimer’s disease and tauopathies
    Bittar, Alice, Sengupta, Urmi, Kayed, Rakez · 2018 · npj Vaccines
  7. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer’s disease
    Stancu, Ilie‐Cosmin, Ris, Laurence, Vasconcelos, Bruno, Marinangeli, Claudia, Goeminne, Léonie, Laporte, Vincent, Haylani, Laetitia E., Couturier, Julien, Schakman, Olivier, Gailly, Philippe et al. · 2014 · The FASEB Journal
  8. Insights on the Use of Transgenic Mice Models in Alzheimer’s Disease Research
    Pádua, Mafalda Soares, Guil-Guerrero, José L., Prates, José A. M., Lopes, Paula Alexandra · 2024 · International Journal of Molecular Sciences
  9. Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice
    Britschgi, Markus, Takeda-Uchimura, Yoshiko, Rockenstein, Edward, Johns, Hudson, Masliah, Eliezer, Wyss-Coray, Tony · 2012 · Journal of Neuroinflammation
  10. Addressing the Discrepancies Between Animal Models and Human Alzheimer’s Disease Pathology: Implications for Translational Research
    Polis, Baruh, Samson, Abraham O. · 2024 · Journal of Alzheimer's Disease
  11. Mechanisms of memory loss in Aβ and tau mouse models
    Ashe, K.H. · 2005 · Biochemical Society Transactions
  12. Hyperphosphorylated tau is a cause of neuronal dysfunction in tauopathy
    Takashima, Akihiko · 2008 · Journal of Alzheimer s Disease
  13. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis
    Selenica, Maj-Linda B, Davtyan, Hayk, Housley, Steven B, Blair, Laura J, Gillies, Anne, Nordhues, Bryce A, Zhang, Bo, Liu, Joseph, Gestwicki, Jason E, Lee, Daniel C et al. · 2014 · Journal of Neuroinflammation
  14. Spatial memory deficiency early in 6xTg Alzheimer’s disease mouse model
    Kang, Shinwoo, Kim, Jinho, Chang, Keun-A · 2021 · Scientific Reports
  15. Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models
    Hannan, Shabab B., Dräger, Nina M., Rasse, Tobias M., Voigt, Aaron, Jahn, Thomas R. · 2016 · Journal of Neurochemistry
  16. A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model
    Vijayan, Murali, Alvir, Rainier Vladlen, Alvir, Razelle Veronique, Bunquin, Lloyd E., Pradeepkiran, Jangampalli Adi, Reddy, P. Hemachandra · 2022 · Aging Cell
  17. Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model
    Nishioka, Christopher, Liang, Hsiao-Fang, Barsamian, Barsam, Sun, Shu-Wei · 2019 · NeuroImage
  18. Tau liquid–liquid phase separation: At the crossroads of tau physiology and tauopathy
    Islam, Majedul, Shen, Fengyun, Regmi, Deepika, Petersen, Katherine, Karim, Md Raza Ul, Du, Deguo · 2024 · Journal of Cellular Physiology
  19. Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice
    Huang, Melissa, Macdonald, Jennifer, Lavenir, Isabelle, Chen, Renren, Craxton, Molly, Slavik-Smith, Elizabeth, Davies, Stephen W., Goedert, Michel · 2022 · eneuro
  20. Passive Immunotherapy Targeting Tau Oligomeric Strains Reverses Tauopathy Phenotypes in Aged Human-Tau Mice in a Mouse Model-Specific Manner
    Bittar, Alice, Al-Lahham, Rabab, Bhatt, Nemil, Moore, Kenya, Montalbano, Mauro, Jerez, Cynthia, Fung, Leiana, McAllen, Salome, Ellsworth, Anna, Kayed, Rakez · 2022 · Journal of Alzheimer's Disease
  21. β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease
    Jiang, Lulu, Roberts, Rebecca, Wong, Melissa, Zhang, Lushuang, Webber, Chelsea Joy, Libera, Jenna, Wang, Zihan, Kilci, Alper, Jenkins, Matthew, Ortiz, Alejandro Rondón et al. · 2024 · Frontiers in Neuroscience