A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model
Open accessAbstract
Abstract Alzheimer's disease (AD) is the most common cause of mental dementia in the aged population. AD is characterized by the progressive decline of memory and multiple cognitive functions, and changes in behavior and personality. Recent research has revealed age‐dependent increased levels of VDAC1 in postmortem AD brains and cerebral cortices of APP, APPxPS1, and 3xAD.Tg mice. Further, we found abnormal interaction between VDAC1 and P‐Tau in the AD brains, leading to mitochondrial structural and functional defects. Our current study aimed to understand the impact of a partial reduction of voltage‐dependent anion channel 1 (VDAC1) protein on mitophagy/autophagy, mitochondrial and synaptic activities, and behavior changes in transgenic TAU mice in Alzheimer's disease. To determine if a partial reduction of VDAC1 reduces mitochondrial and synaptic toxicities in transgenic Tau (P301L) mice, we crossed heterozygote VDAC1 knockout (VDAC1+/−) mice with TAU mice and generated double mutant (VDAC1+/−/TAU) mice. We assessed phenotypic behavior, protein levels of mitophagy, autophagy, synaptic, other key proteins, mitochondrial morphology, and dendritic spines in TAU mice relative to double mutant mice. Partial reduction of VDAC1 rescued the TAU‐induced behavioral impairments such as motor coordination and exploratory behavioral changes, and learning and spatial memory impairments in VDAC1+/−/TAU mice. Protein levels of mitophagy, autophagy, and synaptic proteins were significantly increased in double mutant mice compared with TAU mice. In addition, dendritic spines were significantly increased; the mitochondrial number was significantly reduced, and mitochondrial length was increased in double mutant mice. Based on these observations, we conclude that reduced VDAC1 is beneficial in symptomatic‐transgenic TAU mice.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Disruption of autophagic flux and failure of autophagosomes to fuse with lysosomes result in accumulation of vesicles observed in dystrophic neurites and cell bodies in tauopathy models.
“The disruption of the autophagic flux and the failure of autophagosomes to fuse with lysosomes result in the accumulation of vesicles, which can be observed in dystrophic neurites and cell bodies in tauopathy models [27,28,29].”
From Role of Tau Protein in Neurodegenerative Diseases and Development of Its Targeted Drugs: A Literature Review (2024) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
3 retracted
Mańczak, M., Kandimalla, R. J. L., Yin, X., & Reddy, P. H. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy042 · Cited by 290 · see citing works
Self-citationRetractedKandimalla, R. J. L., Mańczak, M., Yin, X., Wang, R., & Reddy, P. H. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx381 · Cited by 260 · see citing works
Self-citationRetractedKshirsagar, S., Sawant, N. A., Morton, H., Reddy, A. P., & Reddy, P. H. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab262 · Cited by 69 · see citing works
Self-citationRetractedMitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works
Intracellular amyloid-β in Alzheimer's disease
LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works
The pathways of mitophagy for quality control and clearance of mitochondria
Ashrafi, G., & Schwarz, T. L. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.81 · Cited by 1,900 · see citing works
Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0332-9 · Cited by 1,740 · see citing works
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735 · see citing works
Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Murphy, M. P., Baker, M., Yu, X., et al. (2000) · Nature Genetics · doi:10.1038/78078 · Cited by 1,371 · see citing works
Mitochondrial abnormalities in Alzheimer's disease
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357 · see citing works
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224 · see citing works
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Wang, X., Winter, D., Ashrafi, G., Schlehe, J. S., Wong, Y. L., Selkoe, D. J., Rice, S. E., Steen, J. A. J., LaVoie, M. J., & Schwarz, T. L. (2011) · Cell · doi:10.1016/j.cell.2011.10.018 · Cited by 1,161 · see citing works
Matthews, K. A., Xu, W., Gaglioti, A. H., Holt, J. B., Croft, J. B., Mack, D., & McGuire, L. C. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.06.3063 · Cited by 1,124 · see citing works
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function
Wilson, J. E. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00241 · Cited by 1,085 · see citing works
Ishihara, N., Nomura, M., Jofuku, A., Kato, H., Suzuki, S. O., Masuda, K., Otera, H., Nakanishi, Y., Nonaka, I., Goto, Y.-I., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1907 · Cited by 1,066 · see citing works
Reddy, P. H., & Beal, M. F. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.002 · Cited by 975 · see citing works
Self-citationMitochondrial Fusion and Fission in Mammals
Chan, D. C. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104638 · Cited by 972 · see citing works
Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works
Mitochondria and Mitochondrial Cascades in Alzheimer’s disease
Swerdlow, R. H. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170585 · Cited by 850 · see citing works
Mańczak, M., Calkins, M. J., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr139 · Cited by 830 · see citing works
Self-citationNarendra, D. P., Kane, L. A., Hauser, D. N., Fearnley, I. M., & Youle, R. J. (2010) · Autophagy · doi:10.4161/auto.6.8.13426 · Cited by 789 · see citing works
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · cited 1× · see citing works
“…and both in vitro and in vivo models of disease (Calkins et al., 2011; Fang et al., 2019; Kandimalla et al., 2016; Kandimalla et al., 2018; Kerr et al., 2017; Manczak et al., 2011; Reddy, 2014; Reddy et al., 2018; Santos et al., 2010; Su et al., 2010; Swerdlow et al., 2014; Wang et al., 2009).”
BackgroundMitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works
Cipolat, S., Rudka, T., Hartmann, D., Costa, V., Serneels, L., Craessaerts, K., Metzger, K., Frezza, C., Annaert, W. G., D'adamio, L., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.021 · Cited by 735 · see citing works
<i>Drosophila</i> Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
Ziviani, E., Tao, R. N., & Whitworth, A. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913485107 · Cited by 735 · see citing works
Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
Du, H., Guo, L., Yan, S., Sosunov, A. A., McKhann, G. M., & ShiDu Yan, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006586107 · Cited by 704 · see citing works
Epilepsy and Cognitive Impairments in Alzheimer Disease
Palop, J. J. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.15 · Cited by 684 · see citing works
Calkins, M. J., Manczak, M., Mao, P., Shirendeb, U., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr381 · Cited by 646 · see citing works
Self-citationAmyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
Reddy, P. H., & Oliver, D. M. (2019) · Cells · doi:10.3390/cells8050488 · Cited by 496 · cited 1× · see citing works
“…and autophagy in VDAC1+/−/TAU mice Recent studies on VDAC1 revealed that age and P- Tau induced increased synaptic and mitochondrial damage, particularly abnormal regulation of mitophagy and autophagy in the disease process (Manczak & Reddy, 2012; Morton et al., 2021; Reddy & Oliver, 2019).”
BackgroundSelf-citationMitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons
Manczak, M., Mao, P., Calkins, M. J., Cornea, A., Reddy, A. P., Murphy, M. P., Szeto, H. H., Park, B., & Reddy, P. H. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100564 · Cited by 469 · see citing works
Self-citationPerez Ortiz, J. M., & Swerdlow, R. H. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14585 · Cited by 426 · see citing works
AZOULAY-ZOHAR, H., ISRAELSON, A., ABU-HAMAD, S., & SHOSHAN-BARMATZ, V. (2004) · Biochemical Journal · doi:10.1042/bj20031465 · Cited by 408 · see citing works
Rose, I. A., & Warms, J. V. B. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96139-9 · Cited by 399 · see citing works
Pastorino, J. G., Hoek, J. B., & Shulga, N. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1925 · Cited by 398 · see citing works
Microtubule-associated protein tau in development, degeneration and protection of neurons
Wang, J., & Liu, F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.03.002 · Cited by 395 · see citing works
Reddy, P. H., Tripathi, R., Troung, Q., Tirumala, K., Reddy, T. P., Anekonda, V., Shirendeb, U. P., Calkins, M. J., Reddy, A. P., Mao, P., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.011 · Cited by 394 · see citing works
Self-citationRegulation of hexokinase binding to VDAC
Pastorino, J. G., & Hoek, J. B. (2008) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-008-9148-8 · Cited by 388 · see citing works
Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction
Reddy, P. H., Mani, G., Park, B. S., Jacques, J., MURDOCH, G. H., Whetsell, W. O., Kaye, J. A., & Mańczak, M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7203 · Cited by 372 · see citing works
Self-citationSynaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria
John, A., & Reddy, P. H. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101208 · Cited by 359 · see citing works
Self-citationMitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target
Camara, A. K. S., Zhou, Y., Wen, P., Tajkhorshid, E., & Kwok, W.-M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00460 · Cited by 357 · see citing works
Manczak, M., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds360 · Cited by 348 · see citing works
Self-citationReddy, P. H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.052 · Cited by 300 · see citing works
Self-citationReddy, P. H., Yin, X., Mańczak, M., Kumar, S., Pradeepkiran, J. A., Vijayan, M., & Reddy, A. P. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy154 · Cited by 292 · see citing works
Self-citationChiara, F., Castellaro, D., Marin, O., Petronilli, V., Brusilow, W. S. A., Juhaszova, M., Sollott, S. J., Forte, M. A., Bernardi, P., & Rasola, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001852 · Cited by 291 · see citing works
Abnormal mitochondrial dynamics and neurodegenerative diseases
Su, B., Wang, X., Zheng, L., Perry, G. L., Smith, M. A., & Zhu, X. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.09.013 · Cited by 289 · see citing works
Itakura, E., Kishi-Itakura, C., Koyama-Honda, I., & Mizushima, N. (2012) · Journal of Cell Science · doi:10.1242/jcs.094110 · Cited by 286 · see citing works
VDAC1, mitochondrial dysfunction, and Alzheimer’s disease
Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., & Gupta, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.010 · Cited by 286 · see citing works
Abu-Hamad, S., Zaid, H., Israelson, A., Nahon, E., & Shoshan-Barmatz, V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708216200 · Cited by 278 · see citing works
VDAC structure, selectivity, and dynamics
Colombini, M. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.12.026 · Cited by 274 · see citing works
Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains
Ye, X., Sun, X., Starovoytov, V., & Cai, Q. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv056 · Cited by 274 · see citing works
Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer’s Disease
Cai, Q., & Tammineni, P. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160726 · Cited by 274 · see citing works
Stroke, Vascular Dementia, and Alzheimer’s Disease: Molecular Links
Vijayan, M., & Reddy, P. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160527 · Cited by 264 · see citing works
Self-citationMitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases
Cai, Q., & Jeong, Y. Y. (2020) · Cells · doi:10.3390/cells9010150 · Cited by 263 · see citing works
Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination
Ham, S. J., Lee, D. S., Yoo, H., Jun, K., Shin, H., & Chung, J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909814117 · Cited by 251 · see citing works
Sun, Y., Vashisht, A. A., Tchieu, J. H., Wohlschlegel, J. A., & Dreier, L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.419721 · Cited by 244 · see citing works
The Association of Tau With Mitochondrial Dysfunction in Alzheimer’s Disease
Cheng, Y., & Bai, F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00163 · Cited by 239 · see citing works
Mitochondrial Medicine for Aging and Neurodegenerative Diseases
Reddy, P. H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8044-z · Cited by 230 · see citing works
Self-citationMitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
Reddy, P. H., & Reddy, T. P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745401 · Cited by 227 · see citing works
Self-citationAnxiety in Alzheimer's Disease: Prevalence and Comorbidity
Teri, L. L., Ferretti, L. E., Gibbons, L. E., Logsdon, R. G., McCurry, S. M., Kukull, W. A., McCormick, W. C., Bowen, J. D., & Larson, E. B. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.7.m348 · Cited by 227 · see citing works
Tau alteration and neuronal degeneration in tauopathies: mechanisms and models
Brandt, R., Hundelt, M., & Shahani, N. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.018 · Cited by 222 · see citing works
Alterations in Mitochondrial Quality Control in Alzheimer’s Disease
Cai, Q., & Tammineni, P. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00024 · Cited by 215 · see citing works
Potential Therapeutic Benefits of Strategies Directed to Mitochondria
Camara, A. K. S., Lesnefsky, E. J., & Stowe, D. F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2788 · Cited by 195 · see citing works
Ordureau, A., Paulo, J. A., Zhang, W., Ahfeldt, T., Zhang, J., Cohn, E. F., Hou, Z., Heo, J., Rubin, L. L., Sidhu, S. S., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.03.012 · Cited by 184 · see citing works
Weeber, E. J., Levy, M., Sampson, M. J., Anflous, K., Armstrong, D. L., Brown, S. E., Sweatt, J. D., & Craigen, W. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201649200 · Cited by 181 · see citing works
Kandimalla, R. J. L., Mańczak, M., Fry, D., Yeguvapalli, S., Sesaki, H., & Reddy, P. H. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw312 · Cited by 180 · see citing works
Self-citationMorton, H., Kshirsagar, S., Orlov, E., Bunquin, L. E., Sawant, N. A., Boleng, L., George, M., Basu, T., Ramasubramanian, B., Pradeepkiran, J. A., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.013 · Cited by 171 · see citing works
Self-citationDeregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria
Gowda, P., Reddy, P. H., & Kumar, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101529 · Cited by 166 · see citing works
Self-citationSantos, R. X., Correia, S., Wang, X.-L., Perry, G., Smith, M. A., Moreira, P., & Zhu, X.-W. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100666 · Cited by 157 · see citing works
Mah, L., Binns, M. A., & Steffens, D. C. (2014) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2014.10.005 · Cited by 150 · see citing works
Mitochondrial Alterations, Oxidative Stress and Neuroinflammation in Alzheimer's Disease
Verri, M., Pastoris, O., Dossena, M., Aquilani, R., Guerriero, F., Cuzzoni, G., Venturini, L., Ricevuti, G., & Bongiorno, A. I. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500204 · Cited by 144 · see citing works
Reddy, P. H. (2011) · Pharmaceuticals · doi:10.3390/ph4030429 · Cited by 143 · see citing works
Self-citationReddy, P. H. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132060 · Cited by 136 · see citing works
Self-citationTau-mediated synaptic damage in Alzheimer’s disease
Jadhav, S., Cubinkova, V., Zimova, I., Brezováková, V., Maďari, A., Cigánková, V., & Žilka, N. (2015) · Translational Neuroscience · doi:10.1515/tnsci-2015-0023 · Cited by 92 · see citing works
Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance
Han, S., Jeong, Y. Y., Sheshadri, P., Su, X. Y., & Cai, Q. (2020) · EMBO Reports · doi:10.15252/embr.201949801 · Cited by 92 · see citing works
Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?
Reddy, P. H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.09.003 · Cited by 87 · see citing works
Self-citationVDAC proteomics: Post-translation modifications
Kerner, J., Lee, K., Tandler, B., & Hoppel, C. L. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.11.013 · Cited by 74 · see citing works
Reduced VDAC1 Protects Against Alzheimer's Disease, Mitochondria, and Synaptic Deficiencies
Mańczak, M., Sheiko, T. V., Craigen, W. J., & Reddy, P. H. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130761 · Cited by 71 · see citing works
Self-citationSampson, M. J., Lovell, R. S., & Craigen, W. J. (1996) · Genomics · doi:10.1006/geno.1996.0193 · Cited by 69 · see citing works
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice
Hoffmann, N. A., Dorostkar, M. M., Blumenstock, S., Goedert, M., & Herms, J. W. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-82 · Cited by 64 · see citing works
Ye, X., & Cai, Q. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.008 · Cited by 63 · see citing works
Ye, X., Feng, T., Tammineni, P., Chang, Q., Jeong, Y. Y., Margolis, D. J., Cai, H., Kusnecov, A. W., & Cai, Q. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2851-16.2017 · Cited by 62 · see citing works
Pharmacophore-based models for therapeutic drugs against phosphorylated tau in Alzheimer’s disease
Pradeepkiran, J. A., Reddy, A. P., & Reddy, P. H. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.11.005 · Cited by 52 · see citing works
Self-citationBehavioral Abnormalities in Knockout and Humanized Tau Mice
Gonçalves, R. A., Wijesekara, N., Fraser, P. E., & Felice, F. G. D. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00124 · Cited by 50 · see citing works
Lemasters, J. J., Holmuhamedov, E., Czerny, C., Zhong, Z., & Maldonado, E. N. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.11.034 · Cited by 46 · see citing works
Rodrigues-Ferreira, C., da Silva, A. P. P., & Galina, A. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9413-8 · Cited by 44 · see citing works
Mańczak, M., & Reddy, P. H. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.008 · Cited by 41 · see citing works
Self-citationBroad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy
Jeong, Y. Y., Han, S., Jia, N., Zhang, M., Sheshadri, P., Tammineni, P., Cheung, J., Nissenbaum, M., Baskar, S. S., Kwan, K. Y., et al. (2021) · Brain · doi:10.1093/brain/awab243 · Cited by 39 · see citing works
Molecular Links and Biomarkers of Stroke, Vascular Dementia, and Alzheimer's Disease
Vijayan, M., Kumar, S., Bhatti, J. S., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.014 · Cited by 38 · see citing works
Self-citationWu, Z., Zhu, Y., Cao, X., Sun, S., & Zhao, B. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8675-z · Cited by 36 · see citing works
Protective effects of a small molecule inhibitor, DDQ against amyloid beta in Alzheimer’s disease
Vijayan, M., Bose, C., & Reddy, P. H. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.04.005 · Cited by 34 · see citing works
Self-citationMitophagy coordination with retrograde transport ensures the integrity of synaptic mitochondria
Han, S., Jeong, Y. Y., Sheshadri, P., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1810919 · Cited by 33 · see citing works
Jackson, J. G., O’Donnell, J. C., Krizman, E. N., & Robinson, M. B. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23533 · Cited by 32 · see citing works
Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy
Jeong, Y. Y., Han, S., Jia, N., Zhang, M., Sheshadri, P., Tammineni, P., Cheung, J., Nissenbaum, M., Baskar, S. S., Kwan, K. Y., et al. (2022) · UCL Discovery (University College London) · Cited by 32 · see citing works
Wang, Z., Gardiner, N. J., & Fernyhough, P. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.01.057 · Cited by 28 · see citing works
Pradeepkiran, J. A., Reddy, A. P., Yin, X., Mańczak, M., & Reddy, P. H. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz227 · Cited by 25 · see citing works
Self-citationEffect of Increased IL-1β on Expression of HK in Alzheimer’s Disease
Han, S., He, Z., Jacob, C., Hu, X., Liang, X., Xiao, W., Wan, L., Xiao, P., D’Ascenzo, N., Ni, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031306 · Cited by 25 · see citing works
Anti-brain Aging Effects of Small Molecule Inhibitor DDQ
Vijayan, M., Bose, C., & Reddy, P. H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02360-7 · Cited by 21 · see citing works
Self-citationVijayan, M., George, M., Bunquin, L. E., Bose, C., & Reddy, P. H. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab285 · Cited by 18 · see citing works
Self-citationAdenovirus 36 improves glycemic control and markers of Alzheimer's disease pathogenesis
Hegde, V. K., Vijayan, M., Kumar, S., Akheruzzaman, M., Sawant, N. A., Dhurandhar, N. V., & Reddy, P. H. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.08.007 · Cited by 13 · see citing works
Self-citationKartalou, G.-I., Endres, T., Leßmann, V., & Gottmann, K. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108797 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Yang, J., Zhi, W., & Wang, L. (2024) · Molecules · doi:10.3390/molecules29122812 · Cited by 63 · see citing works
- Authors
- Vijayan, M., Alvir, R. V., Alvir, R. V., Bunquin, L. E., Pradeepkiran, J. A., & Reddy, P. H.
- Affiliations
- Texas Tech University (US)
- Corresponding author
- Vijayan, Murali
- Reddy, P. Hemachandra
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2022-07-07
- Volume
- 21
- Issue
- 8
- Pages
- e13663-e13663
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC9381918
- OpenAlex
- W4284971024
- Cited by
- 40
- References
- 103
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 6 · 2023: 4 · 2022: 3
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R41 AG060836, AG066347, AG069333, AG060767, NS105473, AG047812, AG042178)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- VDAC1, Alzheimer's disease, tauopathy, mitophagy, autophagy, synaptic function, dendritic spines, mitochondrial morphology, spatial memory impairment, motor coordination, phosphorylated tau
- MeSH terms
- Alzheimer Disease, Animals, Autophagy, Disease Models, Animal, Mice, Transgenic, tau Proteins, Voltage-Dependent Anion Channel 1, Mice, Mitophagy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
