Mechanisms of memory loss in Aβ and tau mouse models
Abstract
Although memory loss is the central symptom of Alzheimer's disease, the pathophysiological mechanisms leading to dementia are poorly understood. It is difficult to answer this issue with studies in humans and impossible in cultured cells. Therefore animal models are needed to elucidate the molecular mechanisms leading to dementia. The chief neuropathological changes during Alzheimer's disease, namely neurofibrillary tangles and amyloid plaques, have helped us to determine which molecules to focus upon in the animal models, specifically Aβ (amyloid β) and tau. This paper presents my perspective on what we have learnt about mechanisms of memory loss from Aβ and tau mouse models of Alzheimer's disease.
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Many APP transgenic mouse models develop relevant AD-related Aβ pathology and exhibit cognitive impairment within 6 to 12 months of age.
“Though many APP transgenic mouse models have been shown to develop relevant AD-related Aβ pathology and exhibit cognitive impairment within 6 to 12 months of age [2-4]”
From Normal cognition in transgenic BRI2-Aβ mice (2013) · cites this paper as [3]
Cites
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Aβ Oligomers – a decade of discovery
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Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease
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- Authors
- Ashe, K. H.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Ashe, K.H.
- ORCID
- Ashe, K.H.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2005-08-01
- Volume
- 33
- Issue
- 4
- Pages
- 591-594
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2115226576
- Cited by
- 42
- References
- 9
- Citations by year
- 2022: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, memory loss, amyloid-beta, tau protein, mouse model, neurofibrillary tangles, amyloid plaques, dementia pathophysiology
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Humans, Memory Disorders, Mice, Transgenic, Reproducibility of Results, Amyloid beta-Protein Precursor, Neurofibrillary Tangles, tau Proteins, Mice
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