Cited by 2,263Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

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Synaptic plasticity: taming the beast

Abbott, L. F., Nelson, Sacha B.·2000·Nature Neuroscience

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Abstract

Synaptic plasticity provides the basis for most models of learning, memory and development in neural circuits. To generate realistic results, synapse-specific Hebbian forms of plasticity, such as long-term potentiation and depression, must be augmented by global processes that regulate overall levels of neuronal and network activity. Regulatory processes are often as important as the more intensively studied Hebbian processes in determining the consequences of synaptic plasticity for network function. Recent experimental results suggest several novel mechanisms for regulating levels of activity in conjunction with Hebbian synaptic modification. We review three of them-synaptic scaling, spike-timing dependent plasticity and synaptic redistribution-and discuss their functional implications.

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Background
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Background
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Background
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Method
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“dependent changes in synaptic strength as a mechanism for information storage (Abbott and Nelson, 2000; Malenka and Nicoll, 1999).”
Background
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“A prominent mechanism leading to adaptive connectivity is spike-timing dependent plasticity (STDP), which modifies the coupling strengths based on the relative timing of post- and presynaptic spikes (Markram et al., 1997; Abbott and Nelson, 2000; Caporale and Dan, 2008).”
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Authors: Abbott, L. F., & Nelson, S. B.
Affiliations: Brandeis University (US)
Corresponding author: Abbott, L. F.
ORCID: Abbott, L. F.
Nelson, Sacha B.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2000-11
Volume: 3
Issue: S11
Pages: 1178-1183
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/81453
OpenAlex: W1489333352
Cited by: 2,263
References: 51
Citations by year: 2026: 87 · 2025: 129 · 2024: 121 · 2023: 125 · 2022: 122 · 2021: 129 · 2020: 137 · 2019: 103 · 2018: 121 · 2017: 89 · 2016: 94 · 2015: 90 · 2014: 91 · 2013: 82 · 2012: 86
FWCI: 3.62
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ey011116-07)
National Institute of Mental Health (R01MH058754, MH58754)
National Eye Institute (EY11116)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: synaptic plasticity, Hebbian plasticity, long-term potentiation, long-term depression, synaptic scaling, spike-timing-dependent plasticity, learning and memory, neural development
MeSH terms: Action Potentials, Animals, Humans, Models, Neurological, Nerve Net, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses, Receptors, Glutamate, Long-Term Potentiation

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Synaptic plasticity: taming the beast

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