Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 715

The DOI matches its Crossref record.

Y chromosome sequence variation and the history of human populations

Underhill, Peter A., Shen, Peidong, Lin, Alice A., Jin, Li, Passarino, Giuseppe, Yang, Wei H., Kauffman, Erin, Bonné-Tamir, Batsheva, Bertranpetit, Jaume, Francalacci, Paolo, Ibrahim, Muntaser, Jenkins, Trefor, Kidd, Judith R., Mehdi, S. Qasim, Seielstad, Mark T., Wells, R. Spencer, Piazza, Alberto, Davis, Ronald W., Feldman, Marcus W., Cavalli-Sforza, L. Luca, Oefner, Peter. J.·2000·Nature Genetics
DOI 10.1038/81685
Open this paper in CoChat — free account

Abstract

Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.

Overview

Integrity signals

Registry

Crossref · 10.1038/81685

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 26

  1. Hammer, M.F. & Zegura, S.L. The role of the Y chromosome in human evolutionary studies. Evol. Anthropol. 5, 116–134 (1996). · DOI
  2. Oefner, P.J. & Underhill, P.A. DNA mutation detection using denaturing high-performance liquid chromatography. Current Protocols in Human Genetics. Suppl 19, 7.10.1– 7.10.12 (Wiley & Sons, New York, 1998). · DOI
  3. Underhill, P.A. et al. Detection of numerous Y chromosome biallelic polymorphisms by denaturing high performance liquid chromatography (DHPLC). Genome Res. 7, 996–1005 (1997). · DOI
  4. Shen, P. et al. Population genetic implications from sequence variation in four Y chromosome genes. Proc. Natl Acad. Sci. USA 97, 7354–7359 (2000). · DOI
  5. Hammer, M.F. et al. Out of Africa and back again: nested cladistic analysis of human Y chromosome variation. Mol. Biol. Evol. 15, 427–441 (1998). · DOI
  6. Tajima, F. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism Genetics 123, 585–595 (1989). · DOI
  7. Nachman, M.W. Y chromosome variation of mice and men. Mol. Biol. Evol. 15, 1744–1750 (1998).
  8. Jaruzelska, J., Zietkiewicz, E. & Labuda, D. Is selection responsible for the low level of variation in the last intron of the ZFY locus? Mol. Biol. Evol. 16, 1633–1640 (1999). · DOI
  9. Wyckoff, G.J., Wang, W. & Wu, C.I. Rapid evolution of male reproductive genes in the descent of man. Nature 403, 304–309 ( 2000). · DOI
  10. Jorde, L.B. et al. The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome data. Am. J. Hum. Genet. 66, 979–988 ( 2000). · DOI
  11. Thomson, R. et al. Recent common ancestry of human Y chromosomes: Evidence from DNA sequence data. Proc. Natl Acad. Sci. USA 97, 7360–7365 (2000). · DOI
  12. Pritchard, J.K., Seielstad, M.T., Perez-Lezaun, A. & Feldman, M.W. Population growth of human Y chromosomes: a study of Y chromosome microsatellites. Mol. Biol. Evol. 16, 1791–1798 (1999). · DOI
  13. Klein, R.G. The Human Career: Human Biological and Cultural Origins (University of Chicago Press, Illinois, 1999).
  14. Quintana-Murci, L. et al. Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa. Nature Genet. 23 , 437–441 (1999). · DOI
  15. Rogers, A.R. Genetic evidence for a Pleistocene population explosion. Evolution 49, 608–615 ( 1995). · DOI
  16. Vollrath, D. et al. The human Y chromosome: a 43-interval map based on naturally occurring deletions. Science 258, 52– 59 (1992). · DOI
  17. Hammer, M.F. & Horai, S. Y chromosomal DNA variation and the peopling of Japan. Am. J. Hum. Genet. 56, 951–962 (1995).
  18. Seielstad, M.T. et al. Construction of human Y-chromosome haplotypes using a new polymorphic A to G transition. Hum. Mol. Genet. 3, 2159–2161 (1994). · DOI
  19. Hammer, M.F. et al. The geographic distribution of human Y chromosome variation . Genetics 145, 787–805 (1997). · DOI
  20. Zerjal, T. et al. Genetic relationships of Asians and northern Europeans, revealed by Y-chromosomal DNA analysis. Am. J. Hum. Genet. 60 , 1174–1183 (1997).
  21. Bergen, A.W. et al. An Asian-native American paternal lineage identified by RPS4Y resequencing and by microsatellite haplotyping. Ann. Hum Genet. 63, 63–80 ( 1999). · DOI
  22. Bianchi, N.O. et al. Origin of Amerindian Y-chromosomes as inferred by the analysis of six polymorphic markers. Am. J. Phys. Anthropol. 102, 79–89 (1997). · DOI
  23. Diamond, J. Guns, Germs, and Steel (Norton, New York, 1999).
  24. Macaulay, V. et al. The emerging tree of west Eurasian mtDNAs: a synthesis of control-region sequences and RFLPs. Am. J. Hum. Genet. 64, 232–249 (1999). · DOI · Paper page
  25. Jin, L. et al. Distribution of haplotypes from a chromosome 21 region distinguishes multiple prehistoric human migrations. Proc. Natl Acad. Sci. USA 96, 3796–3800 ( 1999). · DOI
  26. Cavalli-Sforza, L.L., Menozzi, P. & Piazza, A. The History and Geography of Human Genes (Princeton University Press, Princeton, New Jersey, 1994).

Cited by

Metadata

Authors
Underhill, P. A., Shen, P., Lin, A. A., Jin, L., Passarino, G., Yang, W. H., Kauffman, E., Bonné-Tamir, B., Bertranpetit, J., Francalacci, P., Ibrahim, M., Jenkins, T., Kidd, J. R., Mehdi, S. Q., Seielstad, M. T., Wells, R. S., Piazza, A., Davis, R. W., Feldman, M. W., Cavalli-Sforza, L. L., & Oefner, P. J.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2000-11
Volume
26
Issue
3
Pages
358-361
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/81685
Cited by
715
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review