The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A neural circuit for circadian regulation of arousal
Abstract
An unknown aspect of behavioral state regulation is how the circadian oscillator of the suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the necessary elements for a circuit that provides circadian regulation of arousal. Trans-synaptic retrograde tracing revealed a prominent indirect projection from the SCN to the noradrenergic nucleus locus coeruleus (LC), a brain arousal system. Double-labeling experiments revealed several possible links between the SCN and the LC, including the dorsomedial (DMH) and paraventricular hypothalamic nuclei (PVN), as well as medial and ventrolateral pre-optic areas. Lesion studies confirmed that the DMH is a substantial relay in this circuit. Next, neurophysiology experiments revealed circadian variations in LC impulse activity. Lesions of the DMH eliminated these circadian changes in LC activity, confirming the functionality of the SCN-DMH-LC circuit. These results reveal mechanisms for regulation of circadian and sleep-waking functions.
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In the citing paper
“Sympathovagal balance is lowest during REM sleep, when the locus coeruleus, the main brain source of catecholamine biosynthesis, is silent.71”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [71]
In the citing paper
“and are important for transitions from focused attention to behavioral flexibility (Aston-Jones et al., 2001)”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Aston-Jones et al., 2001
In the citing paper
“For example, projections from the SCN to the locus coeruleus (LC) facilitate circadian regulation of noradrenergic activity”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Aston-Jones et al., 2001
In the citing paper
“The neuroanatomical circuit mediating circadian regulation of arousal is a multisynaptic pathway between the SCN and the noradrenergic neurons of the LC (Aston-Jones et al., 2001; Deurveilher and Semba, 2005).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Aston-Jones et al., 2001
In the citing paper
“The functional importance of this circuit was demonstrated by the findings that lesions of the DMH eliminate the circadian rhythm in LC neuronal activity, whereas lesions of the LC decrease the amplitude of circadian rhythms of slow-wave activity in the cortex (Aston-Jones et al., 2001).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Aston-Jones et al., 2001
In the citing paper
“As shown by neuroanatomical tract-tracing as well as lesion studies, the neurons in the SCN, which receives retinal input, project to the dorsomedial hypothalamus (DMH), which in turn projects to the LC (Aston-Jones et al., 2001; Deurveilher and Semba, 2005).”
From Biological rhythms, higher brain function, and behavior: Gaps, opportunities, and challenges (2009) · cites this paper as Aston-Jones et al., 2001
In the citing paper
“For example, an indirect projection from the SCN to the locus coeruleus appears to regulate the circadian rhythm in noradrenergic neuronal activity (Aston-Jones et al., 2001).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Aston-Jones et al., 2001
In the citing paper
“Indeed some of the major neurotransmitters that have been implicated in mood regulation, including serotonin, norepinephrine and dopamine, have a circadian rhythm in their levels, release, and synthesis-related enzymes (Weiner et al., 1992; Shieh et al., 1997; Aston-Jones et al., 2001; Barassin et al., 2002; Khaldy et al., 2002; Castaneda et al., 2004; Weber et al., 2004; Malek et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Aston-Jones et al., 2001
Citations
Cites
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Paxinos, G. (1985) · Cited by 3,715
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Aston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960
Self-citationNucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901
Self-citationBrain Maps: Structure of the Rat Brain
Swanson, L. W. (1992) · Medical Entomology and Zoology · Cited by 1,878
Suprachiasmatic nucleus : the mind's clock
Klein, D. C., Moore, R. Y., & Reppert, S. M. (1991) · Cited by 1,715
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Houtz, J., Liao, G., An, J. J., & Xu, B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017218118 · Cited by 27
Feng, N., Telefont, M., Kelly, K. J., Orchinik, M., Forster, G. L., Renner, K. J., & Lowry, C. A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.023 · Cited by 29
Endogenous modulation of human visual cortex activity improves perception at twilight
Cordani, L., Tagliazucchi, E., Vetter, C., Hassemer, C., Roenneberg, T., Stehle, J. H., & Kell, C. A. (2018) · Nature Communications · doi:10.1038/s41467-018-03660-8 · Cited by 30
Van Egroo, M., van Someren, E. J. W., Grinberg, L. T., Bennett, D. A., & Jacobs, H. I. L. (2024) · Annals of Neurology · doi:10.1002/ana.26880 · Cited by 28
The Locus Coeruleus—Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review
Caestecker, S., Lescrauwaet, E., Boon, P., Carrette, E., Raedt, R., & Vonck, K. E. J. (2025) · European Journal of Neurology · doi:10.1111/ene.70337 · Cited by 34
Zheng, F., Zhou, Q., Cao, Y., Shi, H., Wu, H., Zhang, B.-C., Huang, F., & Wu, X. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12458 · Cited by 28
Chronobiology and the horse: Recent revelations and future directions
Murphy, B. A. (2009) · The Veterinary Journal · doi:10.1016/j.tvjl.2009.04.013 · Cited by 29
Singletary, K. G., & Naidoo, N. N. (2011) · Frontiers in Neurology · doi:10.3389/fneur.2011.00066 · Cited by 28
Gompf, H. S., Greenberg, J. H., Aston‐Jones, G., Ianculescu, A. G., Scanlan, T. S., & Dratman, M. B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.067 · Cited by 28
Self-citationA Fast-Slow Analysis of the Dynamics of REM Sleep
Behn, C. D., & Booth, V. (2012) · SIAM Journal on Applied Dynamical Systems · doi:10.1137/110832823 · Cited by 28
Nakayama, H., Kitaichi, K., Ito, Y., Hashimoto, K., Takagi, K., Yokoi, T., Takagi, K., Ozaki, N., Yamamoto, T., & Hasegawa, T. (2007) · Brain Research · doi:10.1016/j.brainres.2007.09.072 · Cited by 28
Sleep deprivation as a method of chronotherapy in the treatment of depression
Dopierała, E., & RYBAKOWSKI, J. K. (2015) · Psychiatria Polska · doi:10.12740/pp/30455 · Cited by 28
Booth, V., Xique, I. J., & Behn, C. D. (2017) · SIAM Journal on Applied Dynamical Systems · doi:10.1137/16m1071328 · Cited by 26
The role of hippocampal adult neurogenesis in methamphetamine addiction
Takashima, Y., & Mandyam, C. D. (2017) · Brain Plasticity · doi:10.3233/bpl-170058 · Cited by 27
Central Control of Circadian Phase in Arousal-Promoting Neurons
Mahoney, C. E., Brewer, J. M., & Bittman, E. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067173 · Cited by 28
Bowrey, H. E., James, M. H., & Aston‐Jones, G. (2017) · Depression and Anxiety · doi:10.1002/da.22635 · Cited by 26
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Scott, M. R., & McClung, C. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-81147-1_9 · Cited by 28
Chronotype differences in cortical thickness: grey matter reflects when you go to bed
Rosenberg, J., Jacobs, H. I. L., Maximov, I. I., Reske, M., & Shah, N. J. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1697-y · Cited by 25
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Kovalzon, V. M. (2016) · Translational Neuroscience and Clinics · doi:10.18679/cn11-6030_r.2016.034 · Cited by 34
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Monk, T. H., & Welsh, D. K. (2003) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(03)90001-3 · Cited by 26
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Imai, R., Makino, H., Katoh, T., Kimura, T., Kurita, T., Hokamura, K., Umemura, K., & Nakajima, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-75434-6 · Cited by 25
Mayorov, D. N. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05469.x · Cited by 25
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Heinrichs, S. C. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.002 · Cited by 25
Shi, M., Hu, Z., Zheng, M., Song, N., Huang, Y., Zhao, G., Han, H., & Ding, Y. (2012) · Journal of Cell Science · doi:10.1242/jcs.102152 · Cited by 25
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Amorim, D., David-Pereira, A., Marques, P., Puga, S., Rebelo, P., Costa, P., Pertovaara, A., Almeida, A., & Pinto‐Ribeiro, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113077 · Cited by 24
Cao, Y. H., Pan, S., Yan, M., Sun, C., Huang, J., Zhong, C., Wang, L., & Lu, Y. (2021) · BMC Biology · doi:10.1186/s12915-021-01187-x · Cited by 25
Light responsiveness of clock genes, Per1 and Per2, in the olfactory bulb of mice
Hamada, T., Honma, S., & Honma, K. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.05.076 · Cited by 24
Luo, S., Zhang, Y., Ezrokhi, M., Li, Y., Tsai, T., & Cincotta, A. H. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12563 · Cited by 24
Sniffing in Infant Rats During Sleep and Wakefulness.
Seelke, A. M. H., & BLUMBERG, M. S. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.2.267 · Cited by 24
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Sprouse, J. S. (2004) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.8.1.25 · Cited by 25
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Calati, R., Gaspar-Barba, E., Yukler, A., & Serretti, A. (2010) · Chronobiology International · doi:10.3109/07420521003681480 · Cited by 23
Nishino, S., & Sakurai, T. (2005) · Contemporary clinical neuroscience · doi:10.1385/1592599508 · Cited by 64
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Hu, W., Li, J., Colwell, C. S., & Zhou, Q. (2011) · SLEEP · doi:10.1093/sleep/34.1.49 · Cited by 23
Shi, M., Guo, C., Dai, J., & Ding, Y. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.07.023 · Cited by 23
McEwen (2004) · doi:10.1016/s1054-3589(04)50016-9 · Cited by 22
Liu, D.-Q., Li, J., Wu, J., Dai, J., Chen, X., Huang, Y., Zhang, S., Tian, B., & Mei, W. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00055 · Cited by 22
Light modulates task-dependent thalamo-cortical connectivity during an auditory attentional task
Paparella, I., Campbell, I., Sharifpour, R., Beckers, E., Berger, A., Aizpurua, J. F. B., Koshmanova, E., Mortazavi, N., Talwar, P., Degueldre, C., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05337-5 · Cited by 22
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Harel, R., Asher, I., Cohen, O. S., Israel, Z. H., Shalit, U., Yanai, Y., Zinger, N., & Prut, Y. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.07.013 · Cited by 23
Alkozei, A., Smith, R. S., & Killgore, W. D. S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.01.034 · Cited by 22
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Gleit, R. D., Behn, C. D., & Booth, V. (2013) · Journal of Biological Rhythms · doi:10.1177/0748730413504277 · Cited by 23
Newman, D. P., Lockley, S. W., Loughnane, G. M., Martins, A. C. P., Abe, R., Zoratti, M. T. R., Kelly, S. P., O'Neill, M., Rajaratnam, S. M. W., O’Connell, R. G., et al. (2016) · Scientific Reports · doi:10.1038/srep27754 · Cited by 21
Use and Visualization of Neuroanatomical Viral Transneuronal Tracers
Card, J. P., & Enquist, L. W. (2012) · Neuromethods · doi:10.1007/978-1-61779-897-9_11 · Cited by 21
Shannon, H. E., Eberle, E. L., Mitch, C. H., McKinzie, D. L., & Statnick, M. A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.09.002 · Cited by 20
Liu, Q., Luo, X., Liang, Z., Qin, D., Xu, M., Wang, M., & Guo, W. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2318030121 · Cited by 22
Frank, E., Benabou, M., Bentzley, B. S., Bianchi, M. T., Goldstein, T. R., Konopka, G., Maywood, E. S., Pritchett, D., Sheaves, B., & Thomas, J. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12600 · Cited by 20
Wang, D., Huang, Y., Wang, X., Chen, X., Li, J., Zhang, S., Wu, J., Liu, D.-Q., Ma, D., & Mei, W. (2020) · British Journal of Anaesthesia · doi:10.1016/j.bja.2020.07.012 · Cited by 21
Gall, A. J., Todd, W. D., & BLUMBERG, M. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045338 · Cited by 20
Chen, Y., Chen, T., & Cai, X. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112862 · Cited by 20
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Kunst, M., Tso, M. C. F., Ghosh, D. D., Herzog, E. D., & Nitabach, M. N. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.985815 · Cited by 20
Horváth, T. L., Abizaid, A. B., Dietrich, M. O., Li, Y., Takahashi, J. S., & Bass, J. T. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.08.003 · Cited by 19
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Wilson, C. G., Akhter, S., Mayer, C. A., Kc, P., Balan, K. V., Ernsberger, P. R., & Haxhiu, M. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01182.2006 · Cited by 18
Collet, J., Ftouni, S., Clough, M., Cain, S. W., Fielding, J., & Anderson, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-63144-y · Cited by 18
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Morin, L. P. (2015) · eNeuro · doi:10.1523/eneuro.0069-14.2015 · Cited by 20
Poletini, M. O., McKee, D. T., Kennett, J. E., Doster, J., & Freeman, M. E. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00341.2007 · Cited by 18
Melatonin enhances the hypoxic response of rat carotid body chemoreceptor
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Stewart, L. S., Nylen, K., Persinger, M. A., Cortez, M. A., Gibson, K. M., & Snead, O. C. (2008) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2008.04.012 · Cited by 18
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Khurram, O. U. H., Negro, F., Heckman, C. J., & Thompson, C. K. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00144.2021 · Cited by 17
Mohammad, S., Ozaki, T., Takeuchi, K., Unno, K., Yamoto, K., Morioka, E., Takiguchi, S., & Ikeda, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.416214 · Cited by 17
Role of locus coeruleus α1‐adrenoceptors in motor activity in rats
Stone, E. A., Lin, Y., Ahsan, R., & Quartermain, D. (2004) · Synapse · doi:10.1002/syn.20074 · Cited by 17
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Cacabelos, R. (2001) · Psychogeriatrics · doi:10.1111/j.1479-8301.2001.tb00046.x · Cited by 17
Arendt, A., Baz, E., & Stengl, M. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24133 · Cited by 15
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Liu, Q., Bell, B. J., Kim, D. W., Lee, S., Keleş, M. F., Liu, Q., Blum, I. D., Wang, A. A., Blank, E. J., Xiong, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41877-4 · Cited by 16
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Bienkowski, M. S., Wendel, E. S., & Rinaman, L. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23356 · Cited by 16
Hooshmand, B., Azizi, H., Javan, M., & Semnanian, S. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.10.051 · Cited by 16
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Sun, W., Yang, Y., Chen, X., Cheng, Y., Li, X., & An, L. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00081 · Cited by 15
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Gilbert, J., & Davis, F. C. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.046 · Cited by 16
Martins, R. C. S., Andersen, M. L., Shih, M., & Tufík, S. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008000100011 · Cited by 16
Wang, Y., Song, Y., Li, T., Wang, L., Cao, J., Qin, G., Liu, X., Mi, W., Wang, E., & Guo, Y. (2022) · iScience · doi:10.1016/j.isci.2022.105913 · Cited by 14
Merica, H., & Fortune, R. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023593 · Cited by 18
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Deboer, T. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.12.015 · Cited by 15
Larson‐Prior, L. J., Ju, Y. S., & Galvin, J. E. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00165 · Cited by 15
Sleep-wake states ub transgenic mouse models overexpressing the human β-amyloid precursor protein
Huitrón‐Reséndiz, S., Sánchez-Alavez, M., & Criado, J. R. (2005) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750502000204 · Cited by 15
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Muzur, A. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.09.011 · Cited by 17
Kvello, P., & Gericke, N. (2021) · PLoS ONE · doi:10.1371/journal.pone.0260752 · Cited by 30
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Metadata
- Authors
- Aston-Jones, G., Chen, S., Zhu, Y., & Oshinsky, M. L.
- Affiliations
- Long Island Jewish Medical Center (US)
- University of Pennsylvania (US)
- Thomas Jefferson University (US)
- Venue
- Nature Neuroscience
- Published
- 2001-07
- Volume
- 4
- Issue
- 7
- Pages
- 732-738
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1488974332
- Cited by
- 632
- References
- 51
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 19 · 2023: 23 · 2022: 14 · 2021: 20 · 2020: 23 · 2019: 16 · 2018: 38 · 2017: 21 · 2016: 31 · 2015: 23 · 2014: 23 · 2013: 22 · 2012: 35
- FWCI
- 9.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS024698, NS 24698)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- circadian rhythm, arousal, suprachiasmatic nucleus, locus coeruleus, noradrenergic system, dorsomedial hypothalamus, paraventricular nucleus, preoptic area, sleep-wake regulation, circadian oscillations, neural circuits, retrograde tracing
- MeSH terms
- Animals, Arousal, Circadian Rhythm, Electrophysiology, Hypothalamus, Immunohistochemistry, Locus Coeruleus, Male, Microinjections, Microscopy, Fluorescence, Herpesvirus 1, Suid, Suprachiasmatic Nucleus, Rats, Sprague-Dawley, Rats
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