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Autoimmune disease: why and where it occurs
Abstract
Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.
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“Consistently, evidence has indicated that interactions between immune cells and non-immune tissues play critical roles in chronic inflammatory diseases and autoimmune diseases (3, 41, 49–51).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [50]
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Metadata
- Authors
- Marrack, P., Kappler, J., & Kotzin, B. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- National Jewish Health (US)
- Venue
- Nature Medicine
- Published
- 2001-08
- Volume
- 7
- Issue
- 8
- Pages
- 899-905
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1522588191
- Cited by
- 609
- References
- 100
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 26 · 2023: 16 · 2022: 20 · 2021: 18 · 2020: 19 · 2019: 17 · 2018: 20 · 2017: 17 · 2016: 14 · 2015: 15 · 2014: 17 · 2013: 24 · 2012: 22
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI-18785, AI 17134, AI 22295, P01AI022295)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 37070, R01AR037070)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- autoimmune disease, genetic susceptibility, environmental factors, immunoreactivity, antigen presentation, autoantigens, pathogenesis
- MeSH terms
- Antigens, Autoimmune Diseases, Chromosome Mapping, Cross Reactions, Humans, Models, Biological
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