Obesity: modern man's fertility nemesis

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2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]

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Body mass index in relation to semen quality and reproductive hormonesamong 1,558 Danish men

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The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996.

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Obesity in anaesthesia and intensive care

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Adipose Tissue: The New Endocrine Organ? A Review Article

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Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic

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Leptin and Androgens in Male Obesity: Evidence for Leptin Contribution to Reduced Androgen Levels

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Subfecundity in overweight and obese couples

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Male obesity and alteration in sperm parameters

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Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function

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AROMATASE INHIBITORS FOR MALE INFERTILITY

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Reduced Fertility Among Overweight and Obese Men

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Reactive oxygen species as an independent marker of male factor infertility

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The secretory function of adipocytes in the physiology of white adipose tissue

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Persistent organochlorines, sedentary occupation, obesity and human male subfertility

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Association of Bioavailable, Free, and Total Testosterone With Insulin Resistance

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The Metabolic Syndrome and Male Infertility

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Changes in sex hormone‐binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome

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Psychobiologic correlates of the metabolic syndrome and associated sexual dysfunction.

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Semen parameters and hormonal profile in obese fertile and infertile males

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Sex Hormones and Sexual Function in Obese Men Losing Weight

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Overweight and seminal quality: a study of 794 patients

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Diet-Induced Obesity in Male Mice Is Associated with Reduced Fertility and Potentiation of Acrylamide-Induced Reproductive Toxicity1

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Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa

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Mild hypogonadotropic hypogonadism in obese men

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Healthcare Utilization and Outcomes After Bariatric Surgery

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Fat Aussie—A New Alström Syndrome Mouse Showing a Critical Role for ALMS1 in Obesity, Diabetes, and Spermatogenesis

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Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer

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Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men

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Recent dynamics suggest selected countries catching up to US obesity

Popkin, B. M. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28473c · Cited by 136 · see citing works

Sex Hormone Changes in Morbidly Obese Patients after Vertical Banded Gastroplasty

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Obesity, low testosterone levels and erectile dysfunction

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Diurnal scrotal skin temperature and semen quality

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Altered Luteinizing Hormone and Testosterone Secretion in Middle‐Aged Obese Men with Obstructive Sleep Apnea

Luboshitzky, R., Lavie, L., Shen‐Orr, Z., & Herer, P. (2005) · Obesity Research · doi:10.1038/oby.2005.88 · Cited by 125 · see citing works

Do reproductive hormones explain the association between body mass index and semen quality?

Qin, D., Yuan, W., Zhou, W., Cui, Y., Wu, J., & Gao, E. (2007) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2007.00268.x · Cited by 120 · see citing works

Reversal of the hypogonadotropic hypogonadism of obese men by administration of the aromatase inhibitor testolactone

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Leptin and leptin receptor in human seminal plasma and in human spermatozoa

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Treatment of male infertility secondary to morbid obesity

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Secondary male factor infertility after Roux-en-Y gastric bypass for morbid obesity: Case report

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The relationship between body mass index and waist circumference: implications for estimates of the population prevalence of overweight

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Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction

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Inhibin‐B Levels in Healthy Young Adult Men and Prepubertal Boys: Is Obesity the Cause for the Contemporary Decline in Sperm Count Because of Fewer Sertoli Cells?

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Influence of a Leptin Deficiency on Testicular Morphology, Germ Cell Apoptosis, and Expression Levels of Apoptosis‐Related Genes in the Mouse

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Should Adipokines be Considered in the Choice of the Treatment of Obesity-Related Health Problems?

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Oxidant stress, inflammation and atherogenesis

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TNF-α and IL-6 affect human sperm function by elevating nitric oxide production

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Sperm chromatin structure is associated with the quality of spermatogenesis in infertile patients.

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Which is the best anthropometric technique to identify obesity: body mass index, waist circumference or waist-hip ratio?

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Evidence that in a physiological setting Sertoli cell number is the major determinant of circulating concentrations of inhibin B in the adult male rhesus monkey (Macaca mulatta).

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Identification of diabetes- and obesity-associated proteomic changes in human spermatozoa by difference gel electrophoresis

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Evidence That in a Physiological Setting Sertoli Cell Number Is the Major Determinant of Circulating Concentrations of Inhibin B in the Adult Male Rhesus Monkey (Macaca mulatto)

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Infertility treatment outcome in sub groups of obese population

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ORIGINAL ARTICLE: The Role of IL‐6, IL‐10, TNF‐α and its Receptors TNFR1 and TNFR2 in the Local Regulatory System of Normal and Impaired Human Spermatogenesis

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An aromatase polymorphism modulates the relationship between weight and estradiol levels in obese men

Hammoud, A. O., Carrell, D. T., Meikle, A. W., Xin, Y., Hunt, S. C., Adams, T. D., & Gibson, M. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.10.037 · Cited by 38 · see citing works

Die physiologische Rolle des Fettgewebes

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Obesity and Erectile Dysfunction

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Obesity and Erectile Dysfunction: Is Androgen Deficiency the Common Link?

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Lifestyle factors and reproductive health: taking control of your fertility

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Role of oxidative stress, infection and inflammation in male infertility

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The complex interaction between obesity, metabolic syndrome and reproductive axis: A narrative review

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Lowered testosterone in male obesity: Mechanisms, morbidity and management

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Obesity and reproduction: a committee opinion

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Obesity and reproduction: a committee opinion

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Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress

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Diet-Induced Obesity in Male C57BL/6 Mice Decreases Fertility as a Consequence of Disrupted Blood-Testis Barrier

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Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility

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Peri-conception parental obesity, reproductive health, and transgenerational impacts

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Endocrine role of bone: recent and emerging perspectives beyond osteocalcin

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Implications of leptin in neuroendocrine regulation of male reproduction

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Inverse U-shaped Association between Sleep Duration and Semen Quality: Longitudinal Observational Study (MARHCS) in Chongqing, China

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The effect of Sertraline, Paroxetine, Fluoxetine and Escitalopram on testicular tissue and oxidative stress parameters in rats

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Oxidative Stress and Male Infertility: Evidence From a Research Perspective

Ayad, B. M., Omolaoye, T. S., Louw, N., Ramsunder, Y., Skosana, B. T., Oyeipo, P. I., & du Plessis, S. S. (2022) · Frontiers in Reproductive Health · doi:10.3389/frph.2022.822257 · Cited by 103 · see citing works

Obesity impairs male fertility through long-term effects on spermatogenesis

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A systematic review on sperm DNA fragmentation in male factor infertility: Laboratory assessment

Selvam, M. K. P., & Agarwal, A. K. (2018) · Arab Journal of Urology · doi:10.1016/j.aju.2017.12.001 · Cited by 95 · see citing works

Impact of Bariatric Surgery on Male Sex Hormones and Sperm Quality: a Systematic Review and Meta-Analysis

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Analysis of human sperm DNA fragmentation index (DFI) related factors: a report of 1010 subfertile men in China

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Dramatic reduction in sperm parameters following bariatric surgery: report of two cases

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Testosterone-Induced Effects on Lipids and Inflammation

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Gut Endotoxin Leading to a Decline IN Gonadal function (GELDING) - a novel theory for the development of late onset hypogonadism in obese men

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Effects of gradual weight loss <i>v</i>. rapid weight loss on body composition and RMR: a systematic review and meta-analysis

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The effect of diet induced obesity on testicular tissue and serum oxidative stress parameters

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The Effect of Aromatase on the Reproductive Function of Obese Males

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Proteomic pattern changes associated with obesity‐induced asthenozoospermia

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Obesity and Sexual Functioning

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Male Fertility, Obesity, and Bariatric Surgery

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The Effect of Bariatric Surgery on Patient HRQOL and Sexual Health During a 1-Year Postoperative Period

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Follicle-stimulating hormone as a predictor for sperm retrieval rate in patients with nonobstructive azoospermia: a systematic review and meta-analysis

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Relationship between Lipids Levels of Serum and Seminal Plasma and Semen Parameters in 631 Chinese Subfertile Men

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Association Study of Single‐Nucleotide Polymorphisms in FASLG, JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR, and TAS2R38 Genes With Male Infertility

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Adult exercise effects on oxidative stress and reproductive programming in male offspring of obese rats

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Proposal of guidelines for the appraisal of SEMen QUAlity studies (SEMQUA)

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Body mass index has no impact on sperm quality but on reproductive hormones levels

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Accelerated aging of reproductive capacity in male rat offspring of protein-restricted mothers is associated with increased testicular and sperm oxidative stress

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Auricular or body acupuncture: which one is more effective in reducing abdominal fat mass in Iranian men with obesity: a randomized clinical trial

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Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity

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Genetic Variation in Circadian Rhythm Genes CLOCK and ARNTL as Risk Factor for Male Infertility

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Obesity, An Enemy of Male Fertility: A Mini Review

Salam, M. A. A. E. (2018) · Oman Medical Journal · doi:10.5001/omj.2018.02 · Cited by 42 · see citing works

Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LβT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice.

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The Impact of Parental Preconception Nutrition, Body Weight, and Exercise Habits on Offspring Health Outcomes: A Narrative Review

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Age as a Predictive Factor of Testosterone Improvement in Male Patients After Bariatric Surgery: Preliminary Results of a Monocentric Prospective Study

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Body mass index and human sperm quality: neither one extreme nor the other

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Taste receptor polymorphisms and male infertility

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Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies

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The Influence of Health in Early Adulthood on Male Fertility

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Physical activity, fatness, educational level and snuff consumption as determinants of semen quality: Findings of the ActiART study

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What Is the Impact of Bariatric Surgery on Erectile Function? A Systematic Review and Meta-Analysis

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Body mass index, waist-to-hip ratio, waist circumference and waist-to-height ratio cannot predict male semen quality: a report of 1231 subfertile Chinese men

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How much obesity and diabetes do impair male fertility?

Abbasihormozi, S., Kouhkan, A., Shahverdi, A., Parikar, A., Shirin, A., & Vesali, S. (2023) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-01034-w · Cited by 34 · see citing works

Effects of thymoquinone on testicular structure and sperm production in male obese rats

Tüfek, N. H., Altunkaynak, M. E., Altunkaynak, B. Z., & Kaplan, S. (2015) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2015.1044135 · Cited by 33 · see citing works

Switching from high-fat diet to normal diet ameliorate BTB integrity and improve fertility potential in obese male mice

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Paternal physical exercise demethylates the hippocampal DNA of male pups without modifying the cognitive and physical development

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Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist

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The Mechanisms Involved in Obesity-Induced Male Infertility

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The Association between Exposure to Environmental Bisphenol A and Gonadotropic Hormone Levels among Men

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The different surrogate measures of adiposity in relation to semen quality and serum reproductive hormone levels among Estonian fertile men

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Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin

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Impact of Physical Activity and Sedentary Behavior on Spontaneous Female and Male Fertility: A Systematic Review

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Oxidative stress burden inhibits spermatogenesis in adult male rats: testosterone protective effect

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Association Between Body Mass Index and Male Sperm Apoptosis and Apoptosis-Related Factors

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What do most erectile dysfunction guidelines have in common? No evidence-based discussion or recommendation of heart-healthy lifestyle changes and/or Panax ginseng

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The impact of obesity on the male reproductive axis.

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The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis

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The effect of different types of exercise training on diet-induced obesity in rats, cross-talk between cell cycle proteins and apoptosis in testis

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Can Male Fertility Be Improved Prior to Assisted Reproduction through The Control of Uncommonly Considered Factors?

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Protective Effects of Pleurotus tuber-regium on Carbon- Tetrachloride Induced Testicular Injury in Sprague Dawley Rats

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Orlistat reverses intratesticular lactate transport decline and infertility in male obese rats

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Effects and possible mechanisms of intermittent fasting on health and disease: a narrative review

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Influence of titanium dioxide nanoparticles and/or cadmium chloride oral exposure on testicular morphology, oxidative stress, and apoptosis in rats: Ameliorative role of co-enzyme Q10

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Decreased visceral fat area correlates with improved total testosterone levels after Roux-en-Y gastric bypass in obese Chinese males with type 2 diabetes: a 12-month follow-up

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Correcting imbalance of sex hormones by a phosphodiesterase 5 inhibitor improves copulatory dysfunction in male rats with type 2 diabetes

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Adiponectin/AdipoRs signaling as a key player in testicular aging and associated metabolic disorders

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INFLUENCE OF MALE OBESITY ON FERTILITY

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Has fertility declined in recent decades?

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‘To[o] much eating stifles the child’: fat bodies and reproduction in early modern England

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Effect of postnatal overfeeding on the male and female Wistar rat reproductive parameters

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PACAP ameliorates the fertility of obese mice through PAC1/PKA/ERK/Nrf2 signal axis

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Semen quality, hormone profile and histological changes in male albino rats treated with Corchorus olitorius leaf extract.

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Unmasking the Epigenome: Insights into Testicular Cell Dynamics and Reproductive Function

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High-Fat Diets Disturb Rat Epididymal Sperm Maturation

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Associations of Semen Quality with Seminal Non-essential Heavy Metals in Males from the Canary Islands

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Brown adipose tissue transplantation ameliorates male fertility impairment caused by diet-induced obesity

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Body Mass Index Effects Kruger's Criteria in Infertile Men.

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The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children

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Hyaluronan bound mature sperm count (HB-MaSC) is a more informative indicator of fertility than conventional sperm parameters: Correlations with Body Mass Index (BMI)

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Seminal plasma adipokines: involvement in human reproductive functions

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Heart Health = Urologic Health and Heart Unhealthy = Urologic Unhealthy: Rapid Review of Lifestyle Changes and Dietary Supplements

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The Role of Obesity in ROS Generation and Male Infertility

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Male Infertility and Assisted Reproductive Technology: Lessons from the IVF

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Management of weight loss in obesity-associated male infertility: a spotlight on bariatric surgery

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Combined effects of obesity and di-(2-ethylhexyl) phthalate on testosterone levels and kisspeptin/GPR54 expression in hypothalamus and testes of male mice

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Serum lipid profile levels and semen quality: new insights and clinical perspectives for male infertility and men’s health

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Diet-induced obesity alters kinematics of rat spermatozoa

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Sperm Dysfunction in the Testes and Epididymides due to Overweight and Obesity Is Not Caused by Oxidative Stress

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The impact of obesity on male reproduction: its biological significance

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Role of Irisin Administration in Modulating Testicular Function in Adult Obese Albino Rats

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Gender Obesity Report – Einfluss von Adipositas auf Reproduktion und Schwangerschaft

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Obesity and Male Fertility

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Obesity, An Enemy of Male Fertility: A Mini Review

Salam, M. A. A. E. (2018) · Oman Medical Journal · doi:10.5001/omj.2018.02 · Cited by 42 · see citing works

BMI and Obesity

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A hormonal, physical, and proteomic view of obesity-induced effects on male infertility and possible lifestyle modifications

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Obesity

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