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Cited by 88Sperm and Testicular FunctionHormonal and reproductive studiesHypothalamic control of reproductive hormones

Obesity and Male Infertility: A Practical Approach

Meikle, A., Reis, Leonardo, Gibson, Mark, Peterson, C., Carrell, Douglas, Hammoud, Ahmad·2012·Seminars in Reproductive Medicine
DOI 10.1055/s-0032-1328877
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Abstract

Obesity in men is associated with infertility in numerous studies, and the temporal trend for a decline in semen parameters parallels the increasing prevalence of obesity in the developed world. In addition to impaired semen quality, fertility among obese men may be affected by decreased libido and erectile dysfunction. This spectrum of expression of hypogonadism among obese men originates from multiple interacting factors including reduced levels of gonadotropins and testosterone, altered androgen-to-estrogen ratios, insulin resistance, and sleep apnea. No evidence-based treatment that increases the likelihood of pregnancy for the infertility associated with male obesity has been demonstrated to date. Interventions associated with improvement of intermediate outcomes that include the endocrine profile, semen parameters, and sexual function may be appropriately selected based on history, physical findings, as well as endocrine and metabolic evaluation. Among these interventions are weight loss through lifestyle change, relief from sleep apnea, use of aromatase inhibitors, gonadotropin administration, phosphodiesterase inhibitors, and insulin-sensitizing agents.

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Registry

Crossref · 10.1055/s-0032-1328877

Cites

16 of 16 references verified0 citation errors · 0 not checkable

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  • Studies have shown that use of aromatase inhibitors, selective estrogen receptor modulators and gonadotropins can improve the endocrine hormonal profile (increased gonadotropins and testosterone), semen parameters and sexual function.

    “Studies, reviewed elsewhere have shown that use of such agents can improve the endocrine hormonal profile (increased gonadotropins and testosterone), semen parameters and sexual function.115”

    From Lowered testosterone in male obesity: Mechanisms, morbidity and management (2014) · cites this paper as [115]

  • However, the effects of aromatase inhibitors, selective estrogen receptor modulators and gonadotropins on fertility are not proven.

    “However, their effects on fertility are not proven.115”

    From Lowered testosterone in male obesity: Mechanisms, morbidity and management (2014) · cites this paper as [115]

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Authors
Meikle, A., Reis, L., Gibson, M., Peterson, C., Carrell, D., & Hammoud, A.
Affiliations
  • Endocrinology/Diabetes Research Department of Medicine
  • Universidade Estadual de Campinas (UNICAMP) (BR)
  • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology
  • University of Utah (US)
Corresponding author
Hammoud, Ahmad
ORCID
Venue
Seminars in Reproductive Medicine
Publisher
Georg Thieme Verlag KG
Published
2012-10-16
Volume
30
Issue
06
Pages
486-495
ISSN
  • 1526-4564 (ISSN-L)
  • 1526-8004
DOI
10.1055/s-0032-1328877
OpenAlex
W2009586633
Cited by
88
References
16
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 13 · 2016: 5 · 2015: 10 · 2014: 10 · 2013: 4
FWCI
8.92
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Reproductive Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
male obesity, male infertility, semen quality, hypogonadism, testosterone, insulin resistance, sleep apnea, erectile dysfunction, sexual desire, aromatase inhibitors, gonadotropins, phosphodiesterase inhibitors, insulin sensitizers, weight loss, lifestyle intervention
MeSH terms
Female, Humans, Hypogonadism, Erectile Dysfunction, Infertility, Male, Male, Models, Biological, Obesity, Pregnancy, Reproduction, Reproductive Techniques, Assisted, Semen Analysis

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