The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Increased Proteasome-Mediated Degradation of Occludin in Irritable Bowel Syndrome
Abstract
OBJECTIVES: Proteasome-mediated protein degradation may contribute to the regulation of intestinal inflammation. At the same time, low-grade inflammation and increased intestinal permeability seem to be involved in the pathophysiology of irritable bowel syndrome (IBS). Thus, we aimed to evaluate proteasome composition and activities in colonic mucosa of IBS patients and its putative pathogenic role. METHODS: Proteasome activities and proteasome subunit expression were measured in colonic mucosa of IBS, Crohn's disease (CD), and control patients by fluorometric assays and western blot, respectively. Expression of inhibitor of kappa B factor (IkappaB alpha) and occludin, a tight junction protein, was also evaluated in colonic biopsies. The degradation of recombinant occludin incubated with protein extracts from colonic mucosa was evaluated in the presence or absence of proteasome inhibitor, MG132. RESULTS: Proteasome trypsin-like activity was increased in IBS patients compared with CD and controls, whereas chymotrypsin-like activity was upregulated in CD patients only. Caspase-like activity was reduced both in IBS and CD patients. IkappaB alpha expression was similar between IBS and controls. In contrast, occludin expression was lower in IBS than in controls, but occludin mRNA level was similar. Protein extracts from IBS patients but not from controls degraded recombinant occludin (20% over 160 min), which was blocked by MG132. Although mast cell number was increased in IBS patients, no correlation was found between this number and proteasome alterations. CONCLUSIONS: Our study shows that proteasome alterations are present in the colonic mucosa of IBS patients and may contribute to the pathophysiology of IBS by increasing occludin degradation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Apart from claudins, expression levels of other TJ proteins, such as JAM-A, occludin, and ZO-1, remain suppressed during intestinal inflammation [194].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [194]
In the citing paper
“Results from examination of cytokine protein levels have been conflicting. In one study, levels of TNF-α were elevated, but levels of IL-6 and interferon-γ were decreased in mucosa of patients with IBS compared with controls (41).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [41]
Citations
Cites
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
Glickman, M. H., & Ciechanover, A. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00027.2001 · Cited by 4,296
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
An Evidence-Based Position Statement on the Management of Irritable Bowel Syndrome
American College of Gastroenterology IBS Task Force (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.122 · Cited by 694
Piche, T., Barbara, G., Aubert, P., Bruley des Varannes, S., Dainese, R., Nano, J. L., Cremon, C., Stanghellini, V, De Giorgio, R., Galmiche, J. P., et al. (2009) · Gut · doi:10.1136/gut.2007.140806 · Cited by 540
Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes
Dunlop, S. P., Hebden, J., Campbell, E., Naesdal, J., Olbe, L., Perkins, A. C., & Spiller, R. C. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00672.x · Cited by 476
An accurate mass tag strategy for quantitative and high-throughput proteome measurements
Smith, R. D., Anderson, G., Lipton, M. S. W., Paša‐Tolić, L., Shen, Y., Conrads, T. P., Veenstra, T. D., & Udseth, H. R. (2002) · PROTEOMICS · doi:10.1002/1615-9861(200205)2:5 · Cited by 431
Jung, T., Catalgol, B., & Grune, T. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.001 · Cited by 401
The IκB/NF-κB system: a key determinant of mucosal inflammation and protection
Jobin, C., & Sartor, R. B. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.3.c451 · Cited by 382
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–185 of 185
Systematic Review and Meta-analysis: Efficacy of Mesalamine in Irritable Bowel Syndrome
Goodoory, V. C., Tuteja, A. K., Black, C. J., & Ford, A. C. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.02.014 · Cited by 30
Update on irritable bowel syndrome program of research.
Heitkemper, M., Jarrett, M. E., & Jun, S. (2013) · Journal of Korean Academy of Nursing · doi:10.4040/jkan.2013.43.5.579 · Cited by 24
Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability
Ghouzali, I., Lemaître, C., Bahlouli, W., Azhar, S., Bôle‐Feysot, C., Méleine, M., Ducrotte, P. R., Déchelotte, P., & Coëffier, M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.08.010 · Cited by 23
Self-citationLee, E. H., Yang, H., & Lee, H. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15174 · Cited by 20
Posttranslational modifications as therapeutic targets for intestinal disorders
Choo, J., Heo, G., Pothoulakis, C., & Im, E. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105412 · Cited by 21
Gatekeepers of the Gut: The Roles of Proteasomes at the Gastrointestinal Barrier
Mohapatra, G., Eisenberg‐Lerner, A., & Merbl, Y. (2021) · Biomolecules · doi:10.3390/biom11070989 · Cited by 23
Bertrand, J., Marion‐Letellier, R., Azhar, S., Chan, P., Legrand, R., Goichon, A., Ghouzali, I., Aziz, M., Vaudry, D., Savoye, G., et al. (2015) · PROTEOMICS · doi:10.1002/pmic.201400304 · Cited by 20
Self-citationRodiño‐Janeiro, B. K., Martínez, C., Fortea, M., Lobo, B., Pigrau, M., Nieto, A., González-Castro, A. M., Salvo‐Romero, E., Guagnozzi, D., Pardo‐Camacho, C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20540-9 · Cited by 20
Li, Y., Yang, T., Yao, Q., Li, S., Fang, E., Li, Y., Liu, C., & Li, W.-M. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13556 · Cited by 21
Functional Gastrointestinal Disorders.
Duffy, M., Boggiano, V. L., Ganesh, R., & Mueller, M. (2023) · Primary Care · doi:10.1016/j.pop.2023.03.006 · Cited by 13
Coëffier, M., Claeyssens, S., Bôle‐Feysot, C., Guérin, C., Maurer, B., Lecleire, S., Lavoinne, A., Donnadieu, N., Cailleux, A.-F., & Déchelotte, P. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.046946 · Cited by 18
Self-citationCoëffier, M., Déchelotte, P., & Ducrotte, P. R. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.057 · Cited by 18
Self-citationWu, L., Oshima, T., Tomita, T., Ohda, Y., Fukui, H., Watari, J., & Miwa, H. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1195-z · Cited by 17
Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S. C., Enck, P., Frieling, T., Haag, S., Holtmann, G., Karaus, M., Keller, J., et al. (2011) · Cited by 17
Evidence-Based Clinical Guidelines for Chronic Diarrhea 2023
Ihara, E., Manabe, N., Ohkubo, H., Ogasawara, N., Ogino, H., Kakimoto, K., Kanazawa, M., Kawahara, H., Kusano, C., Kuribayashi, S., et al. (2024) · Digestion · doi:10.1159/000541121 · Cited by 15
Langlois, L. D., Oddoux, S., Aublé, K., Violette, P., Déchelotte, P., Noël, A., & Coëffier, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087220 · Cited by 18
Self-citationEslampour, E., Ghanadi, K., Aghamohammadi, V., Kazemi, A. M., Mohammadi, R., Vahid, F., & Abbasnezhad, A. (2021) · Nutrition Journal · doi:10.1186/s12937-021-00721-5 · Cited by 17
Bertrand, J., Tennoune, N., Marion‐Letellier, R., Goichon, A., Chan, P., Mbodji, K., Vaudry, D., Déchelotte, P., & Coëffier, M. (2013) · PROTEOMICS · doi:10.1002/pmic.201300082 · Cited by 15
Self-citationHigh methionine diet mediated oxidative stress and proteasome impairment causes toxicity in liver
Derouiche, F., Djemil, R., Sebihi, F. Z., Douaouya, L., Maamar, H., & Benjemana, K. (2024) · Scientific Reports · doi:10.1038/s41598-024-55857-1 · Cited by 14
Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model
Mbodji, K., Torre, S., Haas, V. K., Déchelotte, P., & Marion‐Letellier, R. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.04.002 · Cited by 14
Self-citationThe Role of H2S in the Gastrointestinal Tract and Microbiota
Xiao, A., Liu, C., & Li, J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-16-0991-6_4 · Cited by 13
Sundin, J., Nordlander, S., Eutamène, H., Alquier‐Bacquie, V., Cartier, C., Théodorou, V., Nevé, B. L., Törnblom, H., Simrén, M., & Öhman, L. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13701 · Cited by 13
Soufan, F., Ghosson, A., Jaber, R. A., Ghandour, A., & Uwishema, O. (2025) · Health Science Reports · doi:10.1002/hsr2.70660 · Cited by 18
Use of GELSECTAN® in Patients with Irritable Bowel Syndrome (IBS): an Italian Experience
Bellini, M., Berti, G., Bonfrate, L., Ciranni, F., Ciaula, A. D., Ruscio, M. D., Dell’Era, A., Lambiase, C., Noto, A., Pancetti, A., et al. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s318859 · Cited by 12
Leukocyte–Epithelial Interactions and Mucosal Homeostasis
Matthews, J. D., Weight, C. M., & Parkos, C. A. (2013) · Toxicologic Pathology · doi:10.1177/0192623313511336 · Cited by 12
Coquerel, D., Kušíková, E., Mulder, P. G. H., Coëffier, M., Renet, S., Déchelotte, P., Richard, V. J., Thuillez, C., & Tamion, F. (2013) · Inflammation · doi:10.1007/s10753-013-9622-2 · Cited by 11
Self-citationProvost, M., Brégeon, J., Aubert, P., Duchalais, É., d'Aldebert, E., Vergnolle, N., Neunlist, M., & Meurette, G. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12465 · Cited by 11
Toll-Like Receptor Expression in Irritable Bowel Syndrome: On the Alert for a Microbial Threat?
Barbara, G. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.440 · Cited by 10
Rodiño‐Janeiro, B. K., Pardo‐Camacho, C., Santos, J., & Martínez, C. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00186.2018 · Cited by 10
Андреев, Д. Н., & Dicheva, D. T. (2020) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2020-5-87-95 · Cited by 11
Bertrand, J., Goichon, A., Chan, P., Azhar, S., Lecleire, S., Donnadieu, N., Vaudry, D., Cailleux, A.-F., Déchelotte, P., & Coëffier, M. (2014) · Amino Acids · doi:10.1007/s00726-014-1670-x · Cited by 9
Self-citationLi, Z., He, H., He, H. F., Ni, M., Guo, C., Wan, Z., Zhou, J., Wang, Z., Wang, Y., Cai, H., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111773 · Cited by 8
Mengzhu, S., Yujie, Z., Song, Y., Guo, J., Yuhang, W., Chen, X., Dongmei, G. U., Jianhua, S., & Pei, L. (2023) · PubMed Central · doi:10.19852/j.cnki.jtcm.2023.03.001 · Cited by 8
Preclinical models of irritable bowel syndrome
López‐Gómez, L., Bagüés, A., Uranga, J. A., & Abalo, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821324-7.00012-5 · Cited by 8
Pretorius, L., Staden, A. D. P. V., der Merwe, J. J. V., Henning, N., & Smith, C. (2022) · Inflammopharmacology · doi:10.1007/s10787-021-00906-8 · Cited by 8
Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity
Kim, S. U., Choi, J. A., Han, M., Choi, J., Park, J., Kim, M. S., & Kwon, Y. H. (2024) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2024.097 · Cited by 9
Goichon, A., Bertrand, J., Chan, P., Lecleire, S., Coquard, A., Cailleux, A.-F., Vaudry, D., Déchelotte, P., & Coëffier, M. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.104216 · Cited by 9
Self-citationMartínez, C., Lasitschka, F., Thöni, C., Wohlfarth, C., Braun, A., Granzow, M., Röth, R., Dizdar, V., Rappold, G., Hausken, T., et al. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13868 · Cited by 7
Irritable Bowel Syndrome: Peripheral Mechanisms and Therapeutic Implications
Crisan, I. M., & Dumitrascu, D. L. (2014) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-269 · Cited by 7
Ghouzali, I., Azhar, S., Bôle‐Feysot, C., Ducrotte, P. R., Déchelotte, P., & Coëffier, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.07.014 · Cited by 7
Self-citationJeong, E. S., Jung, H., Choi, E., Yun, K., Lee, A., & Kim, Y. S. (2025) · Scientific Reports · doi:10.1038/s41598-025-88981-7 · Cited by 6
Goichon, A., Bahlouli, W., Ghouzali, I., Chan, P., Vaudry, D., Déchelotte, P., Ducrotte, P. R., & Coëffier, M. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00793 · Cited by 7
Self-citationLiang, Z., & You, G. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061725 · Cited by 6
Maev, I. V., Андреев, Д. Н., Zaborovsky, A. V., & Lobanova, E. G. (2022) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2022-16-7-8-14 · Cited by 7
Friesen, H. J., Singh, M., Singh, V., Schurman, J. V., & Friesen, C. A. (2021) · Gastrointestinal Disorders · doi:10.3390/gidisord3040016 · Cited by 5
Bencivenni, S., Roggiani, S., Zannoni, A., Conti, G., Fabbrini, M., Cotugno, M., Stanzione, R., Pietrangelo, D., Litterio, M., Forte, M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-69961-9 · Cited by 5
Indication of Immune Activation in Patients with Perceived Food Hypersensitivity
Lied, G. A. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2926-0 · Cited by 5
Measurement of novel intestinal secretory and barrier pathways and effects of proteases
Edwinson, A. L., & Grover, M. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13547 · Cited by 5
The multicomponent medication Spascupreel attenuates stress‐induced gut dysfunction in rats
Théodorou, V., Beaufrand, C., Yvon, S., Laforge, G., Burmeister, Y., Müller, A., Seilheimer, B., Bueno, L. P., & Eutamène, H. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13798 · Cited by 5
Alam, M. J., Zhao, T., Wiley, J. W., & Chen, J. D. Z. (2024) · Bioelectronic Medicine · doi:10.1186/s42234-024-00158-1 · Cited by 4
BIOPSYCHOSOCIAL APPROACH OF GASTROINTESTINAL DISORDERS
Pojoga, C., & Stănculete, M. F. (2014) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-289 · Cited by 4
Novel insight in diarrhoea-predominant IBS: miRNAs modulate barrier function
Wouters, M. M. (2017) · Gut · doi:10.1136/gutjnl-2016-313525 · Cited by 4
Gao, X., Frakich, N., Filippini, P., Edwards, L. J., Vinkemeier, U., Gran, B., Tănăsescu, R., Bayraktutan, U., Colombo, S. L., & Constantinescu, C. S. (2022) · Neuropeptides · doi:10.1016/j.npep.2022.102265 · Cited by 4
Inflammation and Cancer: Role of Tight Junctions
Pravoverov, K., Barman, S., Gowrikumar, S., Fatima, I., Yadav, S. K., Otte, M. L., Tamang, R. L., Primeaux, M., Singh, A. B., & Dhawan, P. (2023) · Springer eBooks · doi:10.1007/978-981-99-2415-8_1 · Cited by 3
Functional abdominal pain disorders and asthma: two disorders, but similar pathophysiology?
Kumari, M. V., Amarasiri, L., Rajindrajith, S., & Devanarayana, N. M. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1821652 · Cited by 3
Immune activation in irritable bowel syndrome: from basic to clinic
Bashashati, M. (2017) · NeuroGastroLATAM Reviews · doi:10.24875/ngl.m17000002 · Cited by 3
Miller, L. S., Roland, B. C., Whitson, M., Passi, M., Cheung, M., & Vegesna, A. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00022-0 · Cited by 3
Zhuravlyova, L., & Shekhovtsova, Y. O. (2021) · Modern Gastroenterology · doi:10.30978/mg-2021-2-79 · Cited by 2
Peripheral and Central Mechanisms in Irritable Bowel Syndrome : in search of links
Bednarska, O. (2019) · Linköping University medical dissertations · doi:10.3384/diss.diva-156669 · Cited by 1
Tipple, C., Moiemen, N. S., Ioannou, C., Paglione, M. G., Goodson, S. G., McGee, K. C., O’Neil, D. M., Winder, C. L., Barnett, C., Wolf, A. I., et al. (2020) · Burns Open · doi:10.1016/j.burnso.2020.05.005 · Cited by 1
Exploration of Potential Molecular Targets of Dexmedetomidine in the Intestinal Repair of Burnt Rats
Qin, C., Jiang, Y., Yu, M., Bian, Y., & Yu, Y. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s315952 · Cited by 2
Halliez, M. C. M. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/27133 · Cited by 1
Eslampour, E., Ghanadi, K., Aghamohammadi, V., Kazemi, A. M., Mohammadi, R., Vahid, F., & Abbasnezhad, A. (2021) · Research Square · doi:10.21203/rs.3.rs-178607/v1 · Cited by 1
Die neuronale Mediation von Stress am Beispiel tierexperimenteller Modelle
Stengel, M. (2015) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-12278
Régulation du métabolisme protéique intestinal par les nutriments
Tennoune, N., Bertrand, J., Goichon, A., Déchelotte, P., & Coëffier, M. (2011) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2011.07.001
Self-citationSinagra, E., Rossi, F., Raimondo, D., Pietra, C., Pisciotto, P., Pompei, G., Tomasello, G., Cappello, F., Morreale, G. C., Amvrosiadis, G., et al. (2016)
Guilarte, M. (2014) · TDX (Tesis Doctorals en Xarxa)
Cook, M. D. (2013) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Establishing the influence of dietary fatty acids on the colon through nutrigenomics
Chankova, N. (2013) · Research Explorer (The University of Manchester)
The control of the intestinal epithelium integrity in irritable bowel syndrome patients
Szczepaniak, A., & Zielińska, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821324-7.00004-6
Rome criteria IV – irritable bowel syndrome (2016): what's new?
Svistunov, A. А., Osadchuk, M. A., Осадчук, А. М., & Butorova, L. I. (2018) · Clinical Medicine (Russian Journal) · doi:10.18821/0023-2149-2017-95-11-987-993
Bedmar, M. T. C. (2020) · Linköping University medical dissertations · doi:10.3384/diss.diva-171432
Mucosal Inflammation and Visceral Hypersensitivity in Irritable Bowel Syndrome
Komori, K., Ihara, E., & Akiho, H. (2024) · Springer eBooks · doi:10.1007/978-981-97-8410-3_6
Venable, A. H. (2018) · University of North Texas Digital Library (University of North Texas) · doi:10.12794/metadc1248401
Eslampour, E., Ghanadi, K., Aghamohammadi, V., Kazemi, A. M., Mohammadi, R., Vahid, F., & Abbasnezhad, A. (2021) · Figshare · doi:10.6084/m9.figshare.14870579
Rolland-Fourcade, C. (2017) · theses.fr (ABES) · doi:10.70675/c9123f96z8850z4ac8z9b3fz4bf68951b981
Yakovleva, O. V., Salikhzyanova, A. F., Mullakaeva, A. I., Shaidullov, I. F., Сорокина, Д. М., & Ситдикова, Г. Ф. (2026) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093026030178
Abruzzese, V., Biskou, O., Winberg, M. E., Israelsen, H., Bednarska, O., Walter, S., & Keita, Å. V. (2026) · Neurogastroenterology & Motility · doi:10.1111/nmo.70381
Persistent molecular scars and gut-brain axis remodeling after acute DSS colitis
Comella, F., Gualtieri, C., Travelli, C., Coretti, L., Filibian, M., Opallo, N., Quaranta, V., Pirozzi, C., Melini, S., D’Andrea, A., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108407
Proteomic investigation of the molecular targets of mycophenolic acid in human cells
Qasim, M. (2012) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-529
Metadata
- Authors
- Coëffier, M., Gloro, R., Boukhettala, N., Aziz, M., Lecleire, S., Vandaele, N., Antonietti, M., Savoye, G., Bôle-Feysot, C., Déchelotte, P., Reimund, J. M., & Ducrotté, P.
- Affiliations
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Université de Rouen Normandie (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Venue
- American Journal of Gastroenterology
- Published
- 2010-05
- Volume
- 105
- Issue
- 5
- Pages
- 1181-1188
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2076998894
- Cited by
- 185
- References
- 32
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 11 · 2023: 12 · 2022: 4 · 2021: 17 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 13 · 2016: 17 · 2015: 9 · 2014: 15 · 2013: 16 · 2012: 10
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- irritable bowel syndrome, proteasome, occludin, protein degradation, colonic mucosa, intestinal permeability, tight junctions, Crohn's disease, proteasome activity, caspase-like activity, IκBα, mast cells, low-grade intestinal inflammation
- MeSH terms
- Adult, Analysis of Variance, Biopsy, Needle, Cell Membrane Permeability, Crohn Disease, Female, Humans, Immunohistochemistry, Intestinal Mucosa, Male, Mast Cells, Membrane Proteins, Middle Aged, Probability, Reference Values, Sensitivity and Specificity, Severity of Illness Index, Blotting, Western, Case-Control Studies, Cytokines, Statistics, Nonparametric, Reverse Transcriptase Polymerase Chain Reaction, Irritable Bowel Syndrome, Proteasome Endopeptidase Complex, Young Adult, Occludin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
