The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis
Abstract
OBJECTIVES: The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specific correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies. METHODS: The MEDLINE database (1,946 to present) was searched, and only controlled trials or trials with an established effective comparator that compared both SI and GE were included. RESULTS: Studies were identified for metoclopramide (n=6), domperidone (n=6), cisapride (n=14), erythromycin (n=3), botulinum toxin (n=2), and levosulpiride (n=3). Even though most drugs concomitantly improved symptoms and accelerated GE, no study reported a significant correlation between SI and GE. Moreover, a correlation analysis over all studies using meta-regression did not show a significant relationship between SI and GE. Our findings need to be qualified by inconsistencies in study methods, which is a limitation but also suggests that our findings are robust to methodological factors. CONCLUSIONS: In this review, no evidence of a relationship between SI and GE was identified for different drugs used for the treatment of gastroparesis. This finding questions the use of GE measurement to direct drug development for gastroparesis.
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1 retracted
Janssen, P., Oudenhove, L. V., Bisschops, R., & Tack, J. F. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.078 · Cited by 19
Self-citationRetractedMeta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Improvement of Gastric Emptying in Diabetic Gastroparesis by Erythromycin: Preliminary Studies
Janssens, J., Peeters, T. L., Vantrappen, G., Tack, J., Urbain, J. L., De Roo, M., Muls, E., & Bouillon, R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004123221502 · Cited by 753
Self-citationPathophysiology and treatment of functional dyspepsia
Tack, J., Bisschops, R., & Sarnelli, G. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.030 · Cited by 518
Self-citationRevicki, D. A., Rentz, A. M., Dubois, D., Kahrilas, P., Stanghellini, V., Talley, N. J., & Tack, J. (2004) · Quality of Life Research · doi:10.1023/b:qure.0000021689.86296.e4 · Cited by 418
Self-citationRevicki, D. A., Rentz, A. M., Dubois, D., Kahrilas, P., Stanghellini, V., Talley, N. J., & Tack, J. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01612.x · Cited by 383
Self-citationBotulinum Toxin A for the Treatment of Delayed Gastric Emptying
Friedenberg, F. K., Palit, A., Parkman, H. P., Hanlon, A., & Nelson, D. B. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01676.x · Cited by 370
ASYMPTOMATIC GASTRIC RETENTION IN DIABETICS (GASTROPARESIS DIABETICORUM)
KASSANDER, P. (1958) · Annals of Internal Medicine · doi:10.7326/0003-4819-48-4-797 · Cited by 370
ARTS, J., HOLVOET, L., CAENEPEEL, P., BISSCHOPS, R., SIFRIM, D., VERBEKE, K., JANSSENS, J., & TACK, J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03467.x · Cited by 368
Self-citationParkman, H. P., Yates, K., Hasler, W. L., Nguyen, L., Pasricha, P. J., Snape, W. J., Farrugia, G., Koch, K. L., Abell, T. L., McCallum, R. W., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.10.015 · Cited by 349
Cited by
Gastric emptying and glycaemia in health and diabetes mellitus
Phillips, L. K., Deane, A. M., Jones, K. L., Rayner, C. K., & Horowitz, M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.202 · Cited by 273
Pasricha, P. J., Grover, M., Yates, K. P., Abell, T. L., Bernard, C. E., Koch, K. L., McCallum, R. W., Sarosiek, I., Kuo, B., Bulat, R., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.01.230 · Cited by 268
Bharucha, A. E., Kudva, Y. C., & Prichard, D. O. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00161 · Cited by 252
Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study
Carbone, F., Van den Houte, K., Clevers, E., Andrews, C. N., Papathanasopoulos, A., Holvoet, L., Van Oudenhove, L., Caenepeel, P., Arts, J., Vanuytsel, T., et al. (2019) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000304 · Cited by 206
Self-citationCamilleri, M., & Sanders, K. M. (2022) · Gastroenterology · doi:10.1053/j.gastro.2021.10.028 · Cited by 151
Metadata
- Authors
- Janssen, P., Harris, S. M., Jones, M., Masaoka, T., Farré, R., Törnblom, H., Van Oudenhove, L., Simrén, M., & Tack, J.
- Venue
- American Journal of Gastroenterology
- Published
- 2013-09
- Volume
- 108
- Issue
- 9
- Pages
- 1382-1391
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W1980456997
- Cited by
- 260
- References
- 58
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Janssen, P., Harris, S. M., Jones, M., Masaoka, T., Farré, R., Törnblom, H., Van Oudenhove, L., Simrén, M., & Tack, J. (2013). The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis. American Journal of Gastroenterology. https://doi.org/10.1038/ajg.2013.118
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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