The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Clinical Features of Idiopathic Gastroparesis Vary With Sex, Body Mass, Symptom Onset, Delay in Gastric Emptying, and Gastroparesis Severity
Open accessAbstract
Background & Aims Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the NIDDK Gastroparesis Clinical Research Consortium Registry. Methods Data from medical histories, symptom questionnaires, and 4-hour gastric emptying scintigraphy studies were obtained from patients with IG. Results The mean age of 243 IG patients studied was 41 years; 88% were female, 46% were overweight, 50% had acute onset of symptoms, and 19% reported an initial infectious prodrome. Severe delay in gastric emptying (>35% retention at 4 hours) was present in 28% of patients. Predominant presenting symptoms were nausea (34%), vomiting (19%), and abdominal pain (23%). Women had more severe nausea, satiety, constipation and overall gastroparesis symptoms. Patients who experienced acute onset IG had worse nausea than those with insidious onset. Overweight patients had more bloating and gastric retention at 2 hours, but less severe loss of appetite. Patients with severely delayed gastric emptying had worse vomiting, more severe loss of appetite and overall gastroparesis symptoms. Severe anxiety and depression was present in 36% and 18%, respectively. 86% met criteria for functional dyspepsia, primarily postprandial distress syndrome. Conclusions IG is a disorder that primarily affects young women, beginning acutely in 50% of cases; unexpectedly, many patients are overweight. Severe delay in gastric emptying was associated with more severe symptoms of vomiting and loss of appetite. IG is a diverse syndrome that varies by sex, body mass, symptom onset, and delay in gastric emptying.
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Stanghellini, V., Chan, F. K. L., Hasler, W. L., Malagelada, J. R., Suzuki, H., Tack, J., & Talley, N. J. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.011 · Cited by 1,572
Self-citationClinical Guideline: Management of Gastroparesis
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Self-citationGastric emptying and glycaemia in health and diabetes mellitus
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Metadata
- Authors
- Parkman, H. P., Yates, K., Hasler, W. L., Nguyen, L., Pasricha, P. J., Snape, W. J., Farrugia, G., Koch, K. L., Abell, T. L., McCallum, R. W., Lee, L., Unalp–Arida, A., Tonascia, J., & Hamilton, F.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 140
- Issue
- 1
- Pages
- 101-115.e10
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2091051330
- Cited by
- 349
- References
- 9
- FWCI
- 17.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Parkman, H. P., Yates, K., Hasler, W. L., Nguyen, L., Pasricha, P. J., Snape, W. J., Farrugia, G., Koch, K. L., Abell, T. L., McCallum, R. W., Lee, L., Unalp–Arida, A., Tonascia, J., & Hamilton, F. (2011). Clinical Features of Idiopathic Gastroparesis Vary With Sex, Body Mass, Symptom Onset, Delay in Gastric Emptying, and Gastroparesis Severity. Gastroenterology. https://doi.org/10.1053/j.gastro.2010.10.015
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