The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Adiponectin and Hypertension
Abstract
Adipose tissue secretes a variety of bioactive molecules, also known as adipocytokines or adipokines. Obesity, in particular, visceral fat accumulation, is implicated in the dysregulated secretion of adipocytokines, which can contribute to the development of metabolic syndrome and cardiovascular diseases. Adiponectin is an adipocytokine that is exclusively secreted from adipose tissue, but its plasma levels are reduced in obese subjects, especially those with visceral fat accumulation. Adiponectin has a variety of protective properties against obesity-linked complications, such as hypertension, metabolic dysfunction, atherosclerosis, and ischemic heart disease. Adiponectin exerts the beneficial effects on vascular disorders by directly affecting components of vascular tissue. This review will discuss clinical and experimental findings that examine the role of adiponectin in regulation of hypertension and vascular function.
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“Plasma adiponectin concentration is decreased in patients with obesity, especially those with excess visceral fat, and this downregulation is associated with insulin resistance, impaired glucose metabolism, decreased fatty acid metabolism and ectopic fat accumulation114,115.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [114]
Citations
Cites
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Research works printed but not linked: 2
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Cited by
Sorted by citations
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654
Perivascular adipose tissue: More than just structural support
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Adipocytokines in relation to cardiovascular disease
de Voorde, J. V., Pauwels, B., Boydens, C., & Decaluwé, K. (2013) · Metabolism · doi:10.1016/j.metabol.2013.06.004 · Cited by 215
Mechanisms of Obesity-Induced Gastrointestinal Neoplasia
Alemán, J. O., Eusebi, L. H., Ricciardiello, L., Patidar, K. R., Sanyal, A. J., & Holt, P. R. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.051 · Cited by 201
The influence of perivascular adipose tissue on vascular homeostasis
Szasz, T., Bomfim, G. F., & Webb (2013) · Vascular Health and Risk Management · doi:10.2147/vhrm.s33760 · Cited by 205
Metadata
- Authors
- Ohashi, K., Ouchi, N., & Matsuzawa, Y.
- Affiliations
- Nagoya University (JP)
- Sumitomo Hospital (JP)
- ORCID
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-01
- Volume
- 24
- Issue
- 3
- Pages
- 263-269
- ISSN
- 0895-7061 (ISSN-L)
- 1941-7225
- OpenAlex
- W1968290606
- Cited by
- 127
- References
- 82
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 13 · 2020: 9 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 22 · 2012: 15
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- adiponectin, hypertension, adipokines, adipose tissue, visceral fat, obesity, metabolic syndrome, cardiovascular disease, atherosclerosis, ischemic heart disease, vascular function
- MeSH terms
- Animals, Endothelium, Vascular, Humans, Hypertension, Macrophages, Nitric Oxide, Renin-Angiotensin System, Biomarkers, Cyclooxygenase 2, Adiponectin
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