The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX
Open accessAbstract
The mode of cell death induced by photodynamic treatment (PDT) was studied in two cell lines cultured in monolayer, V79 Chinese hamster fibroblasts and WiDr human colon adenocarcinoma cells. The cells were incubated with 5-aminolaevulinic acid (5-ALA) as a precursor for the endogenously synthesised protoporphyrin IX, which was activated by light. Free DNA ends, owing to internucleosomal DNA cleavage in apoptotic cells, were stained specifically with a fluorescent dye in the terminal deoxynucleotidyl transferase (TdT) assay. The free DNA ends were measured by flow cytometry and the fractions of apoptotic cells determined. Total cell death was measured in a cell survival assay to determine the necrotic fraction after subtraction of the apoptotic fraction. V79 cells did undergo apoptosis while WiDr cells were killed only through necrosis. With time, the apoptotic fraction of V79 cells increased until a maximum was reached about 3-4 h after ALA-PDT treatment. For increasing ALA-PDT doses, a maximal apoptotic fraction 75-85% of the cells was measured at about 85% of total cell death. The flow cytometric assay of apoptosis was confirmed by the typical ladder of oligonucleosomal DNA fragments obtained from agarose gel electrophoresis, by fluorescence micrographs visualising the induced free DNA ends and by electron micrographs showing the typical morphology of apoptotic cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“ALA-PDT has been shown to promote necrotic cell death as well, which is highly dependent on the cell line, PpIX localization, and PDT dose.”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [30]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Gomer, C. J. (1988) · Cited by 4,169
PLASTIC EMBEDDING MIXTURES FOR USE IN ELECTRON MICROSCOPY.
Mollenhauer, H. H. (1964) · PubMed · Cited by 1,985
Chen, Y., & Wu, H. D. (2010) · Chinese Science Bulletin · doi:10.1007/s11434-010-3275-4 · Cited by 1,596
Photodynamic therapy with endogenous protoporphyrin
Kennedy, J. C., Pottier, R. H., & Pross, D. C. (1990) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(90)85083-9 · Cited by 1,509
Photoradiation therapy for the treatment of malignant tumors.
Dougherty, T. J., Kaufman, J., Goldfarb, A., Weishaupt, K. R., Boyle, D. G., & Mittleman, A. (1978) · PubMed · Cited by 1,487
Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor.
Weishaupt, K. R., Gomer, C. J., & Dougherty, T. J. (1976) · PubMed · Cited by 1,418
Apoptosis in cancer therapy: Crossing the threshold
Fisher, D. E. (1994) · Cell · doi:10.1016/0092-8674(94)90518-5 · Cited by 1,315
Histologic fixatives suitable for diagnostic light and electron microscopy.
McDowell, E. M., & Trump, B. F. (1976) · PubMed · Cited by 1,254
THE PHOTODEGRADATION OF PORPHYRINS IN CELLS CAN BE USED TO ESTIMATE THE LIFETIME OF SINGLET OXYGEN
Moan, J. E., & Berg, K. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb03669.x · Cited by 1,010
Self-citation
Cited by
Sorted by citations
The role of apoptosis in response to photodynamic therapy: what, where, why, and how
Oleinick, N. L., Morris, R. L., & Belitchenko, I. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b108586g · Cited by 1,502
Braathen, L. R., Szeimies, R., Basset‐Séguin, N., Bissonnette, R., Foley, P. A., Pariser, D. M., Roelandts, R., Wennberg, A., & Morton, C. A. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.06.006 · Cited by 658
5-Aminolevulinic Acid-Based Photodynamic Therapy: Principles and Experimental Research
Peng, Q., Berg, K., Moan, J., Kongshaug, M., & Nesland, J. M. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08549.x · Cited by 615
Self-citationThe Photobiology of Photodynamic Therapy: Cellular Targets and Mechanisms
Oleinick, N. L., & Evans, H. H. (1998) · Radiation Research · doi:10.2307/3579816 · Cited by 571
Guidelines for topical photodynamic therapy: update
Morton, C. A., McKenna, K. E., & Rhodes, L. E. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08882.x · Cited by 474
Intracellular signaling mechanisms in photodynamic therapy
Almeida, R. D., Manadas, B. J., Carvalho, A. P., & Duarte, C. B. (2004) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2004.05.003 · Cited by 391
Signaling pathways in cell death and survival after photodynamic therapy
Moor, A. C. E. (2000) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00065-8 · Cited by 319
Mitochondria-based photodynamic anti-cancer therapy
Morgan, J., & Oseroff, A. R. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00126-0 · Cited by 276
Current evidence and applications of photodynamic therapy in dermatology
Lin, J., & Wan, M. T. (2014) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s35334 · Cited by 248
Garland, M. J., Cassidy, C. M., Woolfson, D., & Donnelly, R. F. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.55 · Cited by 207
Ultrasound activation of TiO2 in melanoma tumors
Harada, Y., Ogawa, K., Irie, Y., Endo, H., Feril, L. B., Uemura, T., & Tachibana, K. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.012 · Cited by 190
Antimicrobial photodynamic therapy: an effective alternative approach to control fungal infections
Baltazar, L. M., Ray, A., Santos, D. A., Cisalpino, P. S., Friedman, A., & Nosanchuk, J. D. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00202 · Cited by 184
Arnoult, D., Tatischeff, I., Estaquier, J., Girard, M., Sureau, F., Tissier, J. P., Grodet, A., Dellinger, M., Traincard, F., Kahn, A., et al. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.3016 · Cited by 151
Daylight Photodynamic Therapy: An Update
Lee, C.-N., Hsu, R., Chen, H., & Wong, T.-W. (2020) · Molecules · doi:10.3390/molecules25215195 · Cited by 143
Barriers to effective uptake of cancer screening among black and minority ethnic groups
Thomas, V. N., Saleem, T., & Abraham, R. (2005) · International Journal of Palliative Nursing · doi:10.12968/ijpn.2005.11.11.20096 · Cited by 138
The use of 5-aminolaevulinic acid as a photosensitiser in photodynamic therapy and photodiagnosis
Kelty, C., Brown, N. J., Reed, M., & Ackroyd, R. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b201027p · Cited by 132
Aghahosseini, F., Arbabi‐Kalati, F., Fashtami, L. A., Djavid, G. E., Fateh, M., & Beitollahi, J. M. (2006) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20278 · Cited by 129
The Modes of Cell Death Induced by PDT: An Overview
Plaetzer, K., Kiesslich, T., Verwanger, T., & Krammer, B. E. (2003) · Medical Laser Application · doi:10.1078/1615-1615-00082 · Cited by 125
Apoptosis Following Photodynamic Tumor Therapy: Induction, Mechanisms and Detection
Plaetzer, K., Kiesslich, T., Oberdanner, C. B., & Krammer, B. E. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053507648 · Cited by 126
Gallagher, W. M., Allen, L. T., O'Shea, C., Kenna, T., Hall, M. J., Gorman, A., KILLORAN, J. J., & O’Shea, D. F. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602527 · Cited by 113
Juzeniene, A., & Moan, J. E. (2006) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2006.11.002 · Cited by 110
Current Evidence and Applications of Photodynamic Therapy in Dermatology
(2015) · Journal of the Dermatology Nurses’ Association · doi:10.1097/jdn.0000000000000135 · Cited by 109
Everett, H., Barry, M., Sun, X., Lee, S. F., Frantz, C., Berthiaume, L. G., McFadden, G., & Bleackley, R. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011247 · Cited by 102
Photodynamic therapy and cancer: a brief sightseeing tour
Palumbo, G. A. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.2.131 · Cited by 101
Apoptosis induced in vivo by photodynamic therapy in normal brain and intracranial tumour tissue
Lilge, L. D., Portnoy, M., & Wilson, B. C. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1426 · Cited by 99
Lavie, G., Kaplinsky, C., Toren, A., Aizman, I., Meruelo, D., MAZUR, Y., & Mandel, M. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690066 · Cited by 98
A brief overview of photodynamic therapy in Europe
Mitton, D., & Ackroyd, R. (2008) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2008.04.004 · Cited by 95
Gain with no pain? Pain management in dermatological photodynamic therapy
Wang, B., Shi, L., Zhang, Y. F., Zhou, Q., Zheng, J., Szeimies, R., & Wang, X. L. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15344 · Cited by 96
The biology of photodynamic therapy
Moore, J. V., West, C., & Whitehurst, C. (1997) · Physics in Medicine and Biology · doi:10.1088/0031-9155/42/5/012 · Cited by 96
Fuchs, J., Weber, S. U., & Kaufmann, R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00255-5 · Cited by 94
Casas, A. G., Fukuda, H., Venosa, G. M. D., & Batlle, A. M. D. C. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1875 · Cited by 91
Nanoprobes and nanobiosensors for monitoring and imaging individual living cells
Vo‐Dinh, T., Kasili, P. M., & Wabuyele, M. B. (2006) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2005.10.012 · Cited by 88
Wild, S. H., Fischbacher, C., Brock, A., Griffiths, C., & Bhopal, R. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603031 · Cited by 86
Fiber-optic nanosensors for single-cell monitoring
Vo‐Dinh, T., & Kasili, P. M. (2005) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-005-3256-7 · Cited by 84
Owens, A., & Randhawa, G. (2004) · Health & Social Care in the Community · doi:10.1111/j.1365-2524.2004.00511.x · Cited by 82
Bowen’s disease – a review of newer treatment options
Lehmann, P. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s1960 · Cited by 82
The bystander effect in photodynamic inactivation of cells
Dahle, J. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00077-5 · Cited by 78
Granville, D. J., Jiang, H., An, M. T., Levy, J. G., McManus, B. M., & Hunt, D. W. C. (1998) · British Journal of Cancer · doi:10.1038/sj.bjc.6690017 · Cited by 78
Challenges of mediated communication, disclosure and patient autonomy in cross-cultural cancer care
Kai, J., Beavan, J., & Faull, C. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.318 · Cited by 73
Noodt, B. B., Berg, K., Stokke, T., Peng, Q., & Nesland, J. M. (1998) · British Journal of Cancer · doi:10.1038/sj.bjc.6690014 · Cited by 72
Self-citationDélos, S., Carsol, J.-L., Fina, F., Raynaud, J., & Martin, P. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980316)75:6 · Cited by 21
Self-citationBissonnette, R., Shapiro, J., Zeng, H., McLean, D. I., & Lui, H. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03783.x · Cited by 69
Bostad, M., Olsen, C. E., Peng, Q., Berg, K., Høgset, A., & Selbo, P. K. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.008 · Cited by 67
Self-citationFurre, I. E., Møller, M. T. N., Shahzidi, S., Nesland, J. M., & Peng, Q. (2006) · Apoptosis · doi:10.1007/s10495-006-0190-x · Cited by 66
Self-citationBerger, Y., Greppi, A., Siri, O., Neier, R., & Juillerat‐Jeanneret, L. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm000981q · Cited by 62
Gholam, P., Denk, K., Sehr, T., Enk, A. H., & Hartmann, M. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.08.062 · Cited by 61
Eshghi, H., Sazgarnia, A., Rahimizadeh, M., Attaran, N., Bakavoli, M., & Soudmand, S. (2013) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2013.02.003 · Cited by 61
The Mode of Cell Death Induced by Photodynamic Treatment Depends on Cell Density
Dahle, J., Steen, H. B., & Moan, J. E. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb08150.x · Cited by 61
Tyrrell, J., Campbell, S. M., & Curnow, A. (2010) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20943 · Cited by 60
Kriska, T., Korytowski, W., & Girotti, A. W. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01078-x · Cited by 59
Viswanath, D., & Won, Y. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00287 · Cited by 57
Tong, Z., Singh, G., & Rainbow, A. J. (2000) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2000)0710201trotpt2.0.co2 · Cited by 56
Inhibitors of the heme oxygenase – carbon monoxide system: on the doorstep of the clinic?
Kinobe, R. T., Dercho, R. A., & Nakatsu, K. (2008) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y08-066 · Cited by 52
Kuželová, K., Grebeňová, D., Pluskalová, M., Marinov, I., & Hrkal, Z. (2004) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2003.07.007 · Cited by 50
Outcome of patients receiving photodynamic therapy for early esophageal cancer
Corti, L., Skarlatos, J., Boso, C., Cardin, F., Kosma, L., Koukourakis, M. I., Giatromanolaki, A. N., Norberto, L., Shaffer, M., & Beroukas, K. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)00450-8 · Cited by 50
Ran, Z.-H., Rayet, B., Rommelaere, J., & Faisst, S. (1999) · Virus Research · doi:10.1016/s0168-1702(99)00115-x · Cited by 50
Johansson, A., Johansson, T., Thompson, M. S., Bendsøe, N., Svanberg, K., Svanberg, S. R., & Andersson‐Engels, S. (2006) · Journal of Biomedical Optics · doi:10.1117/1.2204027 · Cited by 49
Akita, Y., Kozaki, K., Nakagawa, A., Saito, T., Ito, S., Tamada, Y., Fujiwara, S., Nishikawa, N., Uchida, K., Yoshikawa, K., et al. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06053.x · Cited by 48
Wu, Y., Xing, D., & Chen, W. R. (2006) · Cell Cycle · doi:10.4161/cc.5.7.2630 · Cited by 47
Effect of methylene blue-mediated photodynamic therapy for treatment of basal cell carcinoma
Samy, N. A., Salah, M., Fadel, M., & Ahmed, S. (2014) · Lasers in Medical Science · doi:10.1007/s10103-014-1609-1 · Cited by 45
Photodynamic Antifungal Activity of Hypocrellin A Against Candida albicans
Yang, Y., Wang, C., Zhuge, Y., Zhang, J., Xu, K., Zhang, Q., Zhang, H., Chen, H., Chu, M., & Jia, C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01810 · Cited by 44
Wild, P. J., Krieg, R. C., Seidl, J., Stoehr, R., Reher, K., Hofmann, C., Louhelainen, J., Rosenthal, A., Hartmann, A., Pilarsky, C. P., et al. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0141 · Cited by 43
Wu, R. W. K., Yow, C. M. N., Wong, C. K., & Lam, Y. H. (2011) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2010.12.002 · Cited by 42
Gad, F., Viau, G., Bousbira, M., Bertrand, R., & Bissonnette, R. (2001) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/120347540100500103 · Cited by 40
Gholam, P., Kröhl, V., & Enk, A. H. (2013) · Dermatology · doi:10.1159/000349992 · Cited by 39
Chen, J. Y., Mak, N. K., Wen, J., Leung, W. N., Chen, S. C., Fung, M. C., & Cheung, N. H. (1998) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1998.tb02512.x · Cited by 39
Glycoside Esters of 5-Aminolevulinic Acid for Photodynamic Therapy of Cancer
Vallinayagam, R., Schmitt, F., Barge, J., Wagnières, G., Wenger, V., Neier, R., & Juillerat‐Jeanneret, L. (2008) · Bioconjugate Chemistry · doi:10.1021/bc700324r · Cited by 37
Klein, A. M., Karrer, S., Hörner, C., Werner, A., Heinlin, J., Zeman, F., Koller, M. T., Landthaler, M., Szeimies, R., Gruber, M. A., et al. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13547 · Cited by 36
Scanlon, K., Harding, S., Hunt, K., Petticrew, M. P., Rosato, M., & Williams, R. (2006) · Ethnicity and Health · doi:10.1080/13557850600628307 · Cited by 35
Fidanzi-Dugas, C., Liagre, B., Chemin, G., Perraud, A., Carrion, C., Couquet, C.-Y., Granet, R., Sol, V., & Leger, D. Y. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.02.003 · Cited by 34
Xiang, W., Weingandt, H., Ließmann, F., Klein, S., Stepp, H. G., Baumgartner, R., & Hillemanns, P. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740617peibaa2.0.co2 · Cited by 33
5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy
Howley, R., Chandratre, S., & Chen, B. (2023) · Bioengineering · doi:10.3390/bioengineering10040496 · Cited by 33
Sharfaei, S., Viau, G., Lui, H., Bouffard, D., & Bissonnette, R. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04232.x · Cited by 33
Thissen, M. R. T. M., de Blois, M. W., Robinson, D. J., de Bruijn, H. S., Dutrieux, R. P., Star, W. M., & Neumann, H. A. M. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01571.x · Cited by 31
Lee, J. B., Choi, J. Y., Chun, J. S., Yun, S. J., Lee, S. C., Oh, J., & Park, H. R. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08611.x · Cited by 32
Yoo, K. H., Lee, J. W., Li, K., Kim, B. J., & Kim, M. N. (2010) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2010.01515.x · Cited by 31
5‐aminolaevulinic acid photodynamic therapy in a transgenic mouse model of skin melanoma
Córdoba, F. M., Braathen, L. R., Weissenberger, J., Vallan, C., Kato, M. V., Nakashima, I., Weis, J., & von Felbert, V. (2005) · Experimental Dermatology · doi:10.1111/j.0906-6705.2005.00303.x · Cited by 31
Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT
Tyrrell, J., Campbell, S. M., & Curnow, A. (2010) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2010.03.002 · Cited by 30
Juzeniene, A., & Moan, J. E. (2006) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2006.11.001 · Cited by 30
High energy shock waves (HESW) for sonodynamic therapy: effects on HT-29 human colon cancer cells.
Canaparo, R., Serpe, L., Catalano, M. G., Bosco, O., Zara, G. P., Berta, L., & Frairia, R. (2006) · PubMed · Cited by 29
Li, X., Zhou, Z., Hu, L., Zhang, W. J., & Li, W. (2012) · Journal of Dermatological Treatment · doi:10.3109/09546634.2012.697987 · Cited by 28
Zhang, Y., Liu, W., & Wang, Q. (2023) · Journal of Biophotonics · doi:10.1002/jbio.202200293 · Cited by 27
Yang, J., Chen, A. C.-H., Wu, Q., Jiang, S., Liu, X., Xiong, L., & Xia, Y. (2010) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2010.00495.x · Cited by 27
Molecular changes following topical photodynamic therapy using methyl aminolaevulinate in mouse skin
Choi, J. Y., Park, G. T., Na, E. Y., Wi, H. S., Lee, S., & Lee, J.-B. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.03.019 · Cited by 26
Role of p38MAPK in apoptosis and autophagy responses to photodynamic therapy with Chlorin e6
Qin, X. Y., Wang, X., Wang, P., Zhang, K., & Liu, Q. (2014) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2014.12.001 · Cited by 26
Mendoza‐Garcia, J., Sebastian, A., Allan, E., Allan, D., Mandal, P., Alonso-Rasgado, T. A., & Bayat, A. (2012) · Archives of Dermatological Research · doi:10.1007/s00403-012-1264-y · Cited by 25
Monitoring of cell and tissue responses to photodynamic therapy by electrical impedance spectroscopy
Molckovsky, A., & Wilson, B. C. (2001) · Physics in Medicine and Biology · doi:10.1088/0031-9155/46/4/306 · Cited by 25
Teshigawara, T., Mizuno, M., Ishii, T., Kitajima, Y., Utsumi, F., Sakata, J., Kajiyama, H., Shibata, K., Ishizuka, M., & Kikkawa, F. (2017) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2017.11.013 · Cited by 24
Lucroy, M. D., Ridgway, T. D., Peavy, G. Μ., Krasieva, T. B., Higbee, R. G., Campbell, G. A., & Blaik, M. A. (2003) · Veterinary and Comparative Oncology · doi:10.1046/j.1476-5829.2003.00010.x · Cited by 25
Juknat, A. A., Kotler, M. L., Quaglino, A., Carrillo, N. M., & Hévor, T. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00030.x · Cited by 24
Ridgway, T. D., & Lucroy, M. D. (2003) · American Journal of Veterinary Research · doi:10.2460/ajvr.2003.64.131 · Cited by 23
de Cristóbal, J., STOCKERT, J. C., Villanueva, Á., Rello‐Varona, S., Juarranz, Á., & Cañete, M. (2006) · International Journal of Oncology · doi:10.3892/ijo.28.5.1057 · Cited by 22
Serpe, L., Canaparo, R., Berta, L., Bargoni, A., Zara, G. P., & Frairia, R. (2011) · Technology in Cancer Research & Treatment · doi:10.7785/tcrt.2012.500182 · Cited by 21
The public health agenda and minority ethnic health: a reflection on priorities.
Bhopal, R. (2006) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.99.2.58 · Cited by 19
Spörri, S., Chopra, V., Egger, N. G., Hawkins, H. K., Motamedi, M., Dreher, E. F., & Schneider, H. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(01)00179-8 · Cited by 20
Radzi, R., Osaki, T., Tsuka, T., Imagawa, T., Minami, S., & Okamoto, Y. (2011) · Journal of Veterinary Medical Science · doi:10.1292/jvms.11-0467 · Cited by 19
Treatment of Melanoma and Nonmelanoma Skin Cancer
Rass, K., & Tilgen, W. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77574-6_23 · Cited by 19
Lodge, N. (2001) · European Journal of Cancer Care · doi:10.1046/j.1365-2354.2001.00261.x · Cited by 19
Analysis of apoptotic effects induced by photodynamic therapy in a human biliary cancer cell line.
Nonaka, T., Nanashima, A., Nonaka, M., Uehara, M., Isomoto, H., Asahina, I., & Nagayasu, T. (2010) · PubMed · Cited by 19
Grebeňová, D., Halada, P., Stulík, J., Havlı́ček, V., & Hrkal, Z. (2000) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2000)0720016pcihlc2.0.co2 · Cited by 19
Metadata
- Authors
- Noodt, B., Berg, K., Stokke, T., Peng, Q., & Nesland, J.
- Affiliations
- Cancer Registry of Norway (NO)
- Venue
- British Journal of Cancer
- Published
- 1996-07
- Volume
- 74
- Issue
- 1
- Pages
- 22-29
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC2074599
- OpenAlex
- W1976916629
- Cited by
- 174
- References
- 38
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 2
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- British Journal of Cancer (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Keywords
- photodynamic therapy, 5-aminolevulinic acid, protoporphyrin IX, apoptosis, necrosis, cell death mode, V79 fibroblasts, DNA fragmentation, light activation
- MeSH terms
- Adenocarcinoma, Aminolevulinic Acid, Animals, Cells, Cultured, Colonic Neoplasms, Cricetulus, Fibroblasts, Cricetinae, Humans, Light, Necrosis, Photochemotherapy, Protoporphyrins, Tumor Cells, Cultured, Apoptosis, Photosensitizing Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review


