The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia
Open accessAbstract
Blood samples were collected from 52 incident cases of histologically confirmed prostate cancer, an equal number of cases of benign prostatic hyperplasia (BPH) and an equal number of apparently healthy control subjects. The three groups were matched for age and town of residence in the greater Athens area. Steroid hormones, sex hormone-binding globulin, and insulin-like growth factor 1 (IGF-1) were measured in duplicate by radioimmunoassay in a specialized US centre. Statistical analyses were performed using multiple logistical regression. The results for IGF-1 in relation to prostate cancer and BPH were adjusted for demographic and anthropometric factors, as well as for the other measured hormones. There was no relation between IGF-1 and BPH, but increased values of this hormone were associated with increased risk of prostate cancer; an increment of 60 ng ml(-1) corresponded to an odds ratio of 1.91 with a 95% confidence interval of 1.00-3.73. There was also some evidence for an interaction between high levels of testosterone and IGF-1 in relation to prostate cancer. This finding suggests that, in addition to testosterone, IGF-1 may increase the risk of prostate cancer in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Goustin, A. S., Leof, E. B., Shipley, G. D., & Moses, H. L. (1986) · PubMed · Cited by 530
COHEN, P., PEEHL, D. M., LAMSON, G., & ROSENFELD, R. G. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-2-401 · Cited by 355
Burgess, A. W. (1985) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1985.tb00868.x · Cited by 351
Burfeind, P., Chernicky, C. L., Rininsland, F., Ilan, J., & Ilan, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7263 · Cited by 238
Kanety, H. (1993) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.1.229 · Cited by 236
Pietrzkowski, Z. J., Mulholland, G., Gomella, L. G., Jameson, B. A., Wernicke, D., & Baserga, R. (1993) · PubMed · Cited by 236
Daughaday, W. H. (1990) · Endocrinology · doi:10.1210/endo-127-1-1 · Cited by 226
Risk of endometrial and breast cancer in patients with diabetes mellitus
Weiderpass, E., Gridley, G., Persson, I., Nyrén, O., Ekbom, A., & Adami, H.-O. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970502)71:3<360::aid-ijc9>3.0.co;2-w · Cited by 186
Self-citationAngelloz-Nicoud, P. (1995) · Endocrinology · doi:10.1210/en.136.12.5485 · Cited by 167
Insulin-like Growth Factors in Health and Disease
LeRoith, D., Clemmons, D., Nissley, P., & Rechler, M. M. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-10-854 · Cited by 160
Cited by
Obesity and cancer risk: Emerging biological mechanisms and perspectives
Avgerinos, K. I., Spyrou, N., Mantzoros, C. S., & Dalamaga, M. (2019) · Metabolism · doi:10.1016/j.metabol.2018.11.001 · Cited by 1,567
Self-citationBiology of Prostate-Specific Antigen
Balk, S. P., Ko, Y.-J., & Bubley, G. J. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.083 · Cited by 718
Energy balance and cancer: the role of insulin and insulin-like growth factor-I
Kaaks, R., & Lukanova, A. (2001) · Proceedings of the Nutrition Society · doi:10.1079/pns200070 · Cited by 615
Insulin-like growth factors and cancer
Fürstenberger, G., & Senn, H.-J. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00731-3 · Cited by 536
A meta-analysis of diabetes mellitus and the risk of prostate cancer
Kasper, J. S., & Giovannucci, E. (2006) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0410 · Cited by 491
Metadata
- Authors
- Mantzoros, C., Tzonou, A., Signorello, L., Stampfer, M., Trichopoulos, D., & Adami, H.-O.
- Venue
- British Journal of Cancer
- Published
- 1997-11
- Volume
- 76
- Issue
- 9
- Pages
- 1115-1118
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2031169955
- Cited by
- 366
- References
- 15
- FWCI
- 15.04
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. https://app.cochat.ai/papers/10.1038/bjc.1997.520
- The paper
- Mantzoros, C., Tzonou, A., Signorello, L., Stampfer, M., Trichopoulos, D., & Adami, H.-O. (1997). Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. British Journal of Cancer. https://doi.org/10.1038/bjc.1997.520
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
