Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers
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PURPOSE: The objective of this study was to estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers; and measure the extent to which host, family history, and cancer treatment-related factors modify the risk. PATIENTS AND METHODS: Patients were 810 women, with stage I or II breast cancer, for whom a BRCA1 or BRCA2 mutation had been identified in the family. Patients were followed from the initial diagnosis of cancer until contralateral mastectomy, contralateral breast cancer, death, or last follow-up. RESULTS: Overall, 149 subjects (18.4%) developed a contralateral breast cancer. The 15-year actuarial risk of contralateral breast cancer was 36.1% for women with a BRCA1 mutation and was 28.5% for women with a BRCA2 mutation. Women younger than 50 years of age at the time of breast cancer diagnosis were significantly more likely to develop a contralateral breast cancer at 15 years, compared with those older than 50 years (37.6 vs 16.8%; P=0.003). Women aged <50 years with two or more first-degree relatives with early-onset breast cancer were at high risk of contralateral breast cancer, compared with women with fewer, or no first-degree relatives with breast cancer (50 vs 36%; P=0.005). The risk of contralateral breast cancer was reduced with oophorectomy (RR 0.47; 95% CI 0.30-0.76; P=0.002). CONCLUSION: The risk of contralateral breast cancer risk in BRCA mutation carriers declines with the age of diagnosis and increases with the number of first-degree relatives affected with breast cancer. Oophorectomy reduces the risk of contralateral breast cancer in young women with a BRCA mutation.
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Family history is a predictor of contralateral breast cancer risk in both noncarriers and BRCA1/2 mutation carriers.
“We observed that family history is a predictor of CBC risk in both noncarriers and mutation carriers, which is in line with previous literature.19,21”
From Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in <i>BRCA1/2</i> Mutation Carriers (2016) · cites this paper as [21]
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Self-citationrs15869 at miRNA binding site in BRCA2 is associated with breast cancer susceptibility
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Hereditary Breast and Ovarian Cancer
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- Authors
- Metcalfe, K., Gershman, S., Lynch, H. T., Ghadirian, P., Tung, N., Kim-Sing, C., Olopade, O. I., Domchek, S., McLennan, J., Eisen, A., Foulkes, W. D., Rosen, B., Sun, P., & Narod, S. A.
- Affiliations
- University of Toronto (CA)
- Creighton University (US)
- Centre Hospitalier de l’Université de Montréal (CA)
- Beth Israel Deaconess Medical Center (US)
- University of Chicago (US)
- University of Pennsylvania (US)
- University of California, San Francisco (US)
- Sunnybrook Health Science Centre (CA)
- McGill University (CA)
- University Health Network (CA)
- Women’s College Hospital Research and Innovation Institute (CA)
- Corresponding author
- Narod, S A
- Venue
- British Journal of Cancer
- Published
- 2011-04
- Volume
- 104
- Issue
- 9
- Pages
- 1384-1392
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC3101934
- OpenAlex
- W2002561481
- Cited by
- 232
- References
- 15
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 12 · 2023: 11 · 2022: 15 · 2021: 21 · 2020: 31 · 2019: 13 · 2018: 9 · 2017: 12 · 2016: 17 · 2015: 20 · 2014: 18 · 2013: 21 · 2012: 16
- FWCI
- 11.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (unspecified)
- Locations
- British Journal of Cancer (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Keywords
- contralateral breast cancer, BRCA1 mutation, BRCA2 mutation, hereditary breast cancer, oophorectomy, age at diagnosis, family history (medicine), first-degree relatives, early-onset breast cancer, risk factors, young women
- MeSH terms
- Adult, Age Factors, Aged, Breast Neoplasms, Female, Heterozygote, Humans, Middle Aged, Mutation, Ovariectomy, Predictive Value of Tests, Risk Factors, Cohort Studies, Odds Ratio, Survival Analysis, Neoplasms, Second Primary, Risk Assessment, Genes, BRCA1, Genetic Predisposition to Disease, Genes, BRCA2
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