The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The role of EZH2 in tumour progression
Open accessAbstract
Accumulated evidence shows that EZH2 is deregulated in a wide range of cancer types, and it has a crucial role in stem cell maintenance and tumour development. Therefore, blocking EZH2 expression or activity may represent a promising strategy for anticancer treatment. In this review, we address the current understanding of the mechanisms underlying EZH2 regulation alongside the function of EZH2 gene targets that are involved in cancer progression. Finally, we will describe cancer therapies that target EZH2 or its downstream cascades, which could potentially reverse the oncogenic and stemness properties of the tumour cells to suppress cancer progression and recurrence.
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Targeting HIF-1 for cancer therapy
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“Hypoxia inducible factor (HIF) inhibitors have been used in clinical trials and have shown marked effects in inhibiting tumour growth (Semenza, 2003).”
BackgroundLong non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
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Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
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Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation
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Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
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Repression of E-cadherin by the polycomb group protein EZH2 in cancer
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Self-citation
Cited by
Unravelling the biology of SCLC: implications for therapy
Sabari, J. K., Lok, B. H., Laird, J. H., Poirier, J. T., & Rudin, C. M. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.71 · Cited by 490
Liu, Z., Sun, M., Lu, K., Liu, J., Zhang, M., Wu, W., De, W., Wang, Z., & Wang, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077293 · Cited by 309
Xu, M., Chen, X., Lin, K., Zeng, K., Liu, X., Pan, B., Xu, X., Xu, T., Hu, X., Sun, L., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0894-x · Cited by 298
Role of MYC in medulloblastoma
Roussel, M. F., & Robinson, G. W. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014308 · Cited by 180
Qiu, S., Huang, D., Yin, D., Li, F., Li, X., Kung, H.-F., & Peng, Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.015 · Cited by 87
Metadata
- Authors
- Chang, C.-J., & Hung, M.-C.
- Venue
- British Journal of Cancer
- Published
- 2011-12-20
- Volume
- 106
- Issue
- 2
- Pages
- 243-247
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2004846981
- Cited by
- 332
- References
- 34
- FWCI
- 13.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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