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Suppression of tumorigenicity by MicroRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiforme
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“Moreover, neuronal downregulation of miR-138-5p may also induce cell death indirectly due to the overexpression of its proliferative and cell cycle targets including EZH2, E2F2, E2F3, CDK6, CCND3, or ABL1 [87,88,89].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [89]
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The Polycomb complex PRC2 and its mark in life
Margueron, R., & Reinberg, D. (2011) · Nature · doi:10.1038/nature09784 · Cited by 3,347
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196
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Research works printed but not linked: 52
- Huang, 2009, Oncogenic EGFR signaling networks in glioma, Sci. Signal., 2, 10.1126/scisignal.287re6 · DOI
- Preusser, 2011, Current concepts and management of glioblastoma, Ann. Neurol., 70, 9, 10.1002/ana.22425 · DOI
- Bartel, 2004, MicroRNAs: genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5 · DOI
- Inui, 2010, MicroRNA control of signal transduction, Nat. Rev. Mol. Cell Biol., 11, 252, 10.1038/nrm2868 · DOI
- Asadi-Moghaddam, 2010, Potential role of miRNAs and their inhibitors in glioma treatment, Expert. Rev. Anticancer. Ther., 10, 1753, 10.1586/era.10.168 · DOI
- Bader, 2010, The promise of microRNA replacement therapy, Cancer Res., 70, 7027, 10.1158/0008-5472.CAN-10-2010 · DOI
- Kefas, 2008, MicroRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma, Cancer Res., 68, 3566, 10.1158/0008-5472.CAN-07-6639 · DOI · Paper page
- Webster, 2009, Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7, J. Biol. Chem., 284, 5731, 10.1074/jbc.M804280200 · DOI
- Kefas, 2009, The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors, J. Neurosci., 29, 15161, 10.1523/JNEUROSCI.4966-09.2009 · DOI
- Kefas, 2010, Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells, Neuro Oncol., 12, 1102, 10.1093/neuonc/noq080 · DOI
- Gabriely, 2011, Human glioma growth is controlled by microRNA-10b, Cancer Res., 71, 3563, 10.1158/0008-5472.CAN-10-3568 · DOI · Paper page
- Crea, 2010, Clinical significance of polycomb gene expression in brain tumors, Mol. Cancer, 9, 265, 10.1186/1476-4598-9-265 · DOI · Paper page
- Suva, 2009, EZH2 is essential for glioblastoma cancer stem cell maintenance, Cancer Res., 69, 9211, 10.1158/0008-5472.CAN-09-1622 · DOI
- Orzan, 2011, Enhancer of zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells, Neuropathol. Appl. Neurobiol., 37, 381, 10.1111/j.1365-2990.2010.01132.x · DOI
- Simon, 2008, Roles of the EZH2 histone methyltransferase in cancer epigenetics, Mutat. Res., 647, 21, 10.1016/j.mrfmmm.2008.07.010 · DOI
- Tonini, 2008, Importance of Ezh2 polycomb protein in tumorigenesis process interfering with the pathway of growth suppressive key elements, J. Cell. Physiol., 214, 295, 10.1002/jcp.21241 · DOI
- Michaud, 2010, Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts, Cancer Res., 70, 3228, 10.1158/0008-5472.CAN-09-4559 · DOI
- Chen, 2009, Emerging roles of E2Fs in cancer: an exit from cell cycle control, Nat. Rev. Cancer, 9, 785, 10.1038/nrc2696 · DOI
- Alonso, 2005, Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance, J. Natl Cancer Inst., 97, 1589, 10.1093/jnci/dji340 · DOI
- Polager, 2008, E2F — at the crossroads of life and death, Trends Cell Biol., 18, 528, 10.1016/j.tcb.2008.08.003 · DOI
- Camara-Quintana, 2012, Pathology: commonly monitored glioblastoma markers: EFGR, EGFRvIII, PTEN, and MGMT, Neurosurg. Clin. N. Am., 23, 237, 10.1016/j.nec.2012.01.011 · DOI
- Wang, 2011, MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression, Mol. Cancer Res., 9, 1100, 10.1158/1541-7786.MCR-11-0007 · DOI
- Rivetti di Val Cervo, 2011, p63-microRNA feedback in keratinocyte senescence, Proc. Natl. Acad. Sci. U. S. A., 109, 1133, 10.1073/pnas.1112257109 · DOI
- Siegel, 2009, A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis, Nat. Cell Biol., 11, 705, 10.1038/ncb1876 · DOI · Paper page
- Morton, 2008, microRNA-138 modulates cardiac patterning during embryonic development, Proc. Natl. Acad. Sci. U. S. A., 105, 17830, 10.1073/pnas.0804673105 · DOI
- Kisliouk, 2011, MiR-138 inhibits EZH2 methyltransferase expression and methylation of histone H3 at lysine 27, and affects thermotolerance acquisition, Eur. J. Neurosci., 33, 224, 10.1111/j.1460-9568.2010.07493.x · DOI
- Jiang, 2008, Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma, Int. J. Cancer, 127, 505, 10.1002/ijc.25320 · DOI
- Liu, 2011, MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines, Biochem. J., 440, 23, 10.1042/BJ20111006 · DOI
- Song, 2011, MiR-138 suppresses expression of hypoxia-inducible factor 1alpha (HIF-1alpha) in clear cell renal cell carcinoma 786-O cells, Asian Pac J Cancer Prev, 12, 1307
- Wang, 2012, MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma, Carcinogenesis, 33, 1113, 10.1093/carcin/bgs113 · DOI · Paper page
- Zheng, 2012, The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2, Gut, 61, 278, 10.1136/gut.2011.239145 · DOI
- Wang, 2011, Alterations of microRNAs in cisplatin-resistant human non-small cell lung cancer cells (A549/DDP), Exp. Lung Res., 37, 427, 10.3109/01902148.2011.584263 · DOI
- Seike, 2009, MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers, Proc. Natl. Acad. Sci. U. S. A., 106, 12085, 10.1073/pnas.0905234106 · DOI · Paper page
- Mitomo, 2008, Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines, Cancer Sci., 99, 280, 10.1111/j.1349-7006.2007.00666.x · DOI
- Zhao, 2010, miR-138 might reverse multidrug resistance of leukemia cells, Leuk. Res., 34, 1078, 10.1016/j.leukres.2009.10.002 · DOI · Paper page
- Li, 2011, Grade-specific expression profiles of miRNAs/mRNAs and docking study in human grade I-III astrocytomas, Omics, 15, 673, 10.1089/omi.2011.0064 · DOI
- Chan, 2012, Targeting glioma stem cells by functional inhibition of a prosurvival oncomiR-138 in malignant gliomas, Cell Rep., 2, 591, 10.1016/j.celrep.2012.07.012 · DOI · Paper page
- Brescia, 2012, Current strategies for identification of glioma stem cells: adequate or unsatisfactory?, J. Oncol., 2012, 376894, 10.1155/2012/376894 · DOI
- Jiang, 2010, miR-182 as a prognostic marker for glioma progression and patient survival, Am. J. Pathol., 177, 29, 10.2353/ajpath.2010.090812 · DOI
- Tucker-Burden, 2012, Lectins identify glycan biomarkers on glioblastoma-derived cancer stem cells, Stem Cells Dev., 21, 2374, 10.1089/scd.2011.0369 · DOI
- Chang, 2011, The role of EZH2 in tumour progression, Br. J. Cancer, 106, 243, 10.1038/bjc.2011.551 · DOI
- Smits, 2010, miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis, Oncotarget, 1, 710, 10.18632/oncotarget.205 · DOI
- Lu, 2011, MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2, Cancer Res., 71, 225, 10.1158/0008-5472.CAN-10-1850 · DOI
- Wiedemeyer, 2010, Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM, Proc. Natl. Acad. Sci. U. S. A., 107, 11501, 10.1073/pnas.1001613107 · DOI · Paper page
- Silber, 2008, miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells, BMC Med., 6, 14, 10.1186/1741-7015-6-14 · DOI · Paper page
- Pierson, 2008, Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma, J. Neurooncol., 90, 1, 10.1007/s11060-008-9624-3 · DOI · Paper page
- Berezowska, 2011, Targeting ErbB receptors in high-grade glioma, Curr. Pharm. Des., 17, 2468, 10.2174/138161211797249233 · DOI
- Atlas, 2008, Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature, 455, 1061, 10.1038/nature07385 · DOI · Paper page
- Wu, 2010, Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression, Cell Death Differ., 17, 801, 10.1038/cdd.2009.162 · DOI
- Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 · DOI · Paper page
- Cha, 2005, Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3, Science, 310, 306, 10.1126/science.1118947 · DOI
- Chen, 2010, Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2, Nat. Cell Biol., 12, 1108, 10.1038/ncb2116 · DOI
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MicroRNA expression profile in endometriosis: its relation to angiogenesis and fibrinolytic factors
Braza-Boïls, A., Marí-Alexandre, J., Gilabert, J., Sánchez-Izquierdo, D., España, F., Estellés, A., & Gilabert-Estellés, J. (2014) · Human Reproduction · doi:10.1093/humrep/deu019 · Cited by 164
Hudson, M. B., Woodworth-Hobbs, M. E., Zheng, B., Rahnert, J. A., Blount, M. A., Gooch, J. L., Searles, C. D., & Price, S. R. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00266.2013 · Cited by 137
Maza, R. M., Barreda-Manso, M. A., Reigada, D., Silván, Á., Muñoz-Galdeano, T., Soto, A., del Águila, Á., & Nieto-Díaz, M. (2022) · Biomedicines · doi:10.3390/biomedicines10071559 · Cited by 12
Metadata
- Authors
- Qiu, S., Huang, D., Yin, D., Li, F., Li, X., Kung, H.-F., & Peng, Y.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 1832
- Issue
- 10
- Pages
- 1697-1707
- ISSN
- 0925-4439
- Cited by
- 87
- References
- 2
- Language
- en
- Licence
- Funders
- National Natural Science Foundation of China (81272197, 30973479 and 31070953)
- Oversea Collaboration Grant of NSFC, China (81228010)
- International Collaboration Program of Universities in Guangdong Province (2012gjhz001)
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