Hypoxia-inducible factor: roles in development, physiology, and disease

Chandel, N S; Simon, M C

doi:10.1038/cdd.2008.11

Cited by 26Cancer, Hypoxia, and MetabolismErythropoietin and Anemia TreatmentHigh Altitude and Hypoxia

Hypoxia-inducible factor: roles in development, physiology, and disease

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Chandel, N S, Simon, M C·2008·Cell Death & Differentiation

DOI 10.1038/cdd.2008.11

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HIFs form the core regulatory axis governing cellular responses to hypoxic and oxidative stress, integrating redox signals with metabolic, vascular, and immune responses through genome-wide transcriptional reprogramming.
“Hypoxia-inducible factors form the core regulatory axis governing cellular responses to hypoxic and oxidative stress, integrating redox signals with metabolic, vascular, and immune responses through genome-wide transcriptional reprogramming [[216], [217], [218], [219]].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [216]
In the main text (page unavailable), the paper describes HIF as a transcription factor involved in responses to oxygen deprivation. It says mitochondrial reactive oxygen species and metabolites likely regulate HIF activation, and links HIF to vascular development and inflammatory disease. It does not establish HIF as governing oxidative-stress responses or describe metabolic, vascular, and immune responses as integrated through genome-wide transcriptional reprogramming. (LLM, conf=0.86)
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Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro
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Authors: Chandel, N. S., & Simon, M. C.
Affiliations: Northwestern University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Chandel, N S
ORCID: Chandel, N S
Simon, M C
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2008-03-17
Volume: 15
Issue: 4
Pages: 619-620
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/cdd.2008.11
OpenAlex: W1996372375
Cited by: 26
References: 30
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 1 · 2019: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 3
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › High Altitude and Hypoxia
Keywords: hypoxia-inducible factor, hypoxia, oxygen sensing, carotid body, erythropoietin, pulmonary vasoconstriction, high altitude, pulmonary hypertension, chronic obstructive pulmonary disease, sepsis, myocardial ischemia, cancer, development (biology)
MeSH terms: Endothelial PAS Domain-Containing Protein 1, Animals, Hypoxia, Humans, Stem Cells, Signal Transduction, MicroRNAs, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit

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