All roads lead to ubiquitin
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Major negative regulators of necrosome include STUB1, A20, PPM1B, and AURKA.
“Major negative regulators of the necrosome include: (1) STIP1 homology and U-box containing protein 1 (STUB1; also known as CHIP), which promotes RIPK1 and RIPK3 ubiquitination followed by lysosomal degradation [472, 473]; (2) A20, which inhibits necrosome assembly by deubiquitinating RIPK3 [473, 474]; (3) protein phosphatase, Mg2+/Mn2+ dependent 1B (PPM1B), which prevents MLKL recruitment to the”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [473]
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Cites
Ubiquitination in disease pathogenesis and treatment
Popovic, D., Vucic, D., & Đikić, I. (2014) · Nature Medicine · doi:10.1038/nm.3739 · Cited by 1,405 · see citing works
The increasing complexity of the ubiquitin code
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Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages
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Initiation and execution mechanisms of necroptosis: an overview
Grootjans, S., Vanden Berghe, T., & Vandenabeele, P. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.65 · Cited by 566 · see citing works
CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different
Lork, M., Verhelst, K., & Beyaert, R. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.46 · Cited by 282 · see citing works
Regulation of NF‐κB by deubiquitinases
Harhaj, E. W., & Dixit, V. M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01100.x · Cited by 259 · see citing works
Linear ubiquitination in immunity
Shimizu, Y., Taraborrelli, L., & Walczak, H. (2015) · Immunological Reviews · doi:10.1111/imr.12309 · Cited by 135 · see citing works
Diverse ubiquitin linkages regulate RIP kinases-mediated inflammatory and cell death signaling
Witt, A., & Vucic, D. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.33 · Cited by 126 · see citing works
The role of hybrid ubiquitin chains in the MyD88 and other innate immune signalling pathways
Cohen, P., & Strickson, S. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.17 · Cited by 123 · see citing works
Roles of linear ubiquitinylation, a crucial regulator of NF ‐κB and cell death, in the immune system
Sasaki, K., & Iwaï, K. (2015) · Immunological Reviews · doi:10.1111/imr.12308 · Cited by 110 · see citing works
The paracaspase MALT1: biological function and potential for therapeutic inhibition
Jaworski, M., & Thome, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2059-z · Cited by 109 · see citing works
Met1‐linked ubiquitination in immune signalling
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Self-citationFeltham, R., & Silke, J. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.67 · Cited by 33 · see citing works
SPATA2: more than a missing link
Schlicher, L., Brauns‐Schubert, P., Schubert, F., & Maurer, U. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.26 · Cited by 26 · see citing works
Flagged first, then by citations
Research works printed but not linked: 14
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Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
The interplay of autophagy and non-apoptotic cell death pathways
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.12.004 · Cited by 50 · see citing works
- Authors
- Gyrd-Hansen, M.
- Venue
- Cell Death & Differentiation
- Published
- 2017-06-26
- Volume
- 24
- Issue
- 7
- Pages
- 1135-1136
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC5520178
- OpenAlex
- W2630047952
- Cited by
- 15
- References
- 14
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ludwig Institute for Cancer Research
- Wellcome Trust (102894/Z/13/Z)
- Danmarks Frie Forskningsfond
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- ubiquitination, ubiquitin, post-translational modification, polyubiquitin chains, lysine conjugation, ubiquitin system, cell death, inflammatory signalling, pathogen defense, genome stability
- MeSH terms
- Animals, Humans, Inflammation, Models, Biological, Protein Processing, Post-Translational, Signal Transduction, Ubiquitin, Ubiquitination
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