Cannabidiol protects oligodendrocyte progenitor cells from inflammation-induced apoptosis by attenuating endoplasmic reticulum stress
Open accessAbstract
Cannabidiol (CBD) is the most abundant cannabinoid in Cannabis sativa that has no psychoactive properties. CBD has been approved to treat inflammation, pain and spasticity associated with multiple sclerosis (MS), of which demyelination and oligodendrocyte loss are hallmarks. Thus, we investigated the protective effects of CBD against the damage to oligodendrocyte progenitor cells (OPCs) mediated by the immune system. Doses of 1 μM CBD protect OPCs from oxidative stress by decreasing the production of reactive oxygen species. CBD also protects OPCs from apoptosis induced by LPS/IFNγ through the decrease of caspase 3 induction via mechanisms that do not involve CB1, CB2, TRPV1 or PPARγ receptors. Tunicamycin-induced OPC death was attenuated by CBD, suggesting a role of endoplasmic reticulum (ER) stress in the mode of action of CBD. This protection against ER stress-induced apoptosis was associated with reduced phosphorylation of eiF2α, one of the initiators of the ER stress pathway. Indeed, CBD diminished the phosphorylation of PKR and eiF2α induced by LPS/IFNγ. The pro-survival effects of CBD in OPCs were accompanied by decreases in the expression of ER apoptotic effectors (CHOP, Bax and caspase 12), and increased expression of the anti-apoptotic Bcl-2. These findings suggest that attenuation of the ER stress pathway is involved in the 'oligoprotective' effects of CBD during inflammation.
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CBD exerts antioxidant activities against toxicity induced by different agents, such as amphetamine.
“Furthermore, CBD exerts antioxidant activities against toxicity induced different agents, such as amphetamine (89, 116, 121)”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [121]
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- Authors
- Mecha, M., Torrao, A. S., Mestre, L., Carrillo-Salinas, F. J., Mechoulam, R., & Guaza, C.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Guaza, C
- Venue
- Cell Death & Disease
- Published
- 2012-06-28
- Volume
- 3
- Issue
- 6
- Pages
- e331-e331
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC3388241
- OpenAlex
- W2064802817
- Cited by
- 140
- References
- 36
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 6 · 2023: 13 · 2022: 12 · 2021: 16 · 2020: 17 · 2019: 14 · 2018: 14 · 2017: 11 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 5 · 2012: 1
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Cell Death and Disease (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III (RD07/0060/0010)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- cannabidiol, oligodendrocyte precursor cells, endoplasmic reticulum stress, apoptosis, neuroinflammation, multiple sclerosis, oxidative stress, reactive oxygen species, caspase-3, PKR, eIF2α, CHOP, Bcl-2, Bax, caspase-12, demyelination, cannabinoid receptors
- MeSH terms
- Animals, Cannabidiol, Inflammation, Oligodendroglia, Stem Cells, Rats, Wistar, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Receptors, Cannabinoid, Rats, Endoplasmic Reticulum Stress
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