Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders

Campos, Alline C.; Fogaça, Manoela V.; Scarante, Franciele F.; Joca, Sâmia R. L.; Sales, Amanda J.; Gomes, Felipe V.; Sonego, Andreza B.; Rodrigues, Naielly S.; Galve-Roperh, Ismael; Guimarães, Francisco S.

doi:10.3389/fphar.2017.00269

Cited by 175Cannabis and Cannabinoid ResearchPsychedelics and Drug StudiesNeuroscience and Neuropharmacology Research

Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders

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Campos, Alline C., Fogaça, Manoela V., Scarante, Franciele F., Joca, Sâmia R. L., Sales, Amanda J., Gomes, Felipe V., Sonego, Andreza B., Rodrigues, Naielly S. +2 more·2017·Frontiers in Pharmacology

DOI 10.3389/fphar.2017.00269PMC PMC5441138

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Abstract

Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and depression. The mechanisms responsible for these effects, however, are still poorly understood. Similar to clinical antidepressant or atypical antipsychotic drugs, recent findings clearly indicate that CBD, either acutely or repeatedly administered, induces plastic changes. For example, CBD attenuates the decrease in hippocampal neurogenesis and dendrite spines density induced by chronic stress and prevents microglia activation and the decrease in the number of parvalbumin-positive GABA neurons in a pharmacological model of schizophrenia. More recently, it was found that CBD modulates cell fate regulatory pathways such as autophagy and others critical pathways for neuronal survival in neurodegenerative experimental models, suggesting the potential benefit of CBD treatment for psychiatric/cognitive symptoms associated with neurodegeneration. These changes and their possible association with CBD beneficial effects in psychiatric disorders are reviewed here.

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CBD has antioxidant activity, acting against the exacerbation of ROS/RNS production and consequent DNA oxidation, polyunsaturated fatty acid peroxidation, and protein nitration/carbonylation.
“CBD also has antioxidants activity, acting against the exacerbation of oxygen/nitrogen species (ROS/RNS) production and consequently DNA oxidation, polyunsaturated fatty acids peroxidation and nitration/carbonylation of proteins, leading to cell injury or death (112).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [112]
Chronic CBD treatment increases autophagy in animals submitted to chronic unpredictable stress, as observed by effects on phosphorylated mTOR, Beclin-1 and LC3.
“Recent findings from our group suggest that chronic CBD treatment increase autophagy in animals submitted to CUS, as observed by its effect in phosphorylated form of mTOR, Beclin-1 and LC3, signaling proteins involved in autophagy induction (112).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [112]

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Fogaça M. V. (2016). Mechanisms Involved in the Behavioral and Pro-neurogenic Effects of Repeated Administration of Cannabidiol in Mice Submitted to the Chronic Unpredictable Stress. Ph.D. Thesis, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo.
James W. (1890). The Principles of Psychology, Chapter IV-Habits. New York, NY: Henry Holt and Company.

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Authors: Campos, A. C., Fogaça, M. V., Scarante, F. F., Joca, S. R. L., Sales, A. J., Gomes, F. V., Sonego, A. B., Rodrigues, N. S., Galve-Roperh, I., & Guimarães, F. S.
Affiliations: Universidade de São Paulo (BR)
University of Pittsburgh (US)
Corresponding author: Campos, Alline C.
ORCID: Campos, Alline C.
Fogaça, Manoela V.
Scarante, Franciele F.
Joca, Sâmia R. L.
Sales, Amanda J.
Gomes, Felipe V.
Sonego, Andreza B.
Guimarães, Francisco S.
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2017-05-23
Volume: 8
Pages: 269-269
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2017.00269
PMC: PMC5441138
OpenAlex: W2619979905
Cited by: 175
References: 197
Citations by year: 2026: 8 · 2025: 13 · 2024: 30 · 2023: 11 · 2022: 20 · 2021: 22 · 2020: 31 · 2019: 15 · 2018: 23 · 2017: 2
FWCI: 2.46
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Ministerio de Economía y Competitividad (S2010/BMD-2336)
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Instituto de Salud Carlos III (PI15/00310)
European Regional Development Fund (S2010/BMD-2336)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: cannabidiol, neuroplasticity, neuroprotection, mental illness, anxiety, psychosis, depression, schizophrenia, hippocampal neurogenesis, dendritic spine density, chronic stress, microglial activation, parvalbumin interneurons, autophagy, neurodegeneration, cognitive symptoms

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Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders

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