The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Molecular mechanisms of hepatic apoptosis
Open accessAbstract
Apoptosis is a prominent feature of liver diseases. Causative factors such as alcohol, viruses, toxic bile acids, fatty acids, drugs, and immune response, can induce apoptotic cell death via membrane receptors and intracellular stress. Apoptotic signaling network, including membrane death receptor-mediated cascade, reactive oxygen species (ROS) generation, endoplasmic reticulum (ER) stress, lysosomal permeabilization, and mitochondrial dysfunction, is intermixed each other, but one mechanism may dominate at a particular stage. Mechanisms of hepatic apoptosis are complicated by multiple signaling pathways. The progression of liver disease is affected by the balance between apoptotic and antiapoptotic capabilities. Therapeutic options of liver injury are impacted by the clear understanding toward mechanisms of hepatic apoptosis.
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Cited by
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
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Metadata
- Authors
- Wang, K.
- Venue
- Cell Death & Disease
- Published
- 2014-01-16
- Volume
- 5
- Issue
- 1
- Pages
- e996-e996
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2070549269
- Cited by
- 329
- References
- 118
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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