The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Role of Mitochondria in Nonalcoholic Fatty Liver Disease
Open accessAbstract
Nonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Significant insight has been gained into our understanding of the pathogenesis of NALFD; however the key metabolic aberrations underlying lipid accumulation in hepatocytes and the progression of NAFLD remain to be elucidated. Accumulating and emerging evidence indicate that hepatic mitochondria play a critical role in the development and pathogenesis of steatosis and NAFLD. Here, we review studies that document a link between the pathogenesis of NAFLD and hepatic mitochondrial dysfunction with particular focus on new insights into the role of impaired fatty acid oxidation, the transcription factor peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and sirtuins in development and progression of NAFLD.
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Cites
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Autophagy regulates lipid metabolism
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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
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Human Fatty Liver Disease: Old Questions and New Insights
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“Hepatic steatosis is defined as liver content exceeding 5% of liver weight [3–6].”
BackgroundSIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature · doi:10.1038/nature08778 · Cited by 1,687
Regulation of hepatic fatty acid oxidation and ketone body production
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“Hepatic β-oxidation provides ketone bodies (acetoacetate and β-hydroxyacetate), which are important fuel for extra-hepatic organs such as the brain when blood glucose levels are low [62,63].”
Background
Cited by
Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
Ipsen, D. H., Lykkesfeldt, J., & Tveden-Nyborg, P. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2860-6 · Cited by 1,471
Mikolasevic, I., Orlic, L., Franjic, N., Hauser, G., Stimac, D., & Milic, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7236 · Cited by 273
Winther-Sørensen, M., Galsgaard, K. D., Santos, A., Trammell, S. A. J., Sulek, K., Kuhre, R. E., Pedersen, J., Andersen, D. B., Hassing, A. S., Dall, M., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101080 · Cited by 135
Sabag, A., Barr, L., Armour, M., Armstrong, A., Baker, C. J., Twigg, S. M., Chang, D., Hackett, D. A., Keating, S. E., George, J., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab795 · Cited by 88
Lu, W., Mei, J., Yang, J., Wu, Z., Liu, J., Miao, P., Chen, Y., Wen, Z., Zhao, Z., Kong, H., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117601 · Cited by 65
Metadata
- Authors
- Nassir, F., & Ibdah, J.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2014-05-15
- Volume
- 15
- Issue
- 5
- Pages
- 8713-8742
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2070188060
- Cited by
- 364
- References
- 47
- FWCI
- 12.36
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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