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Cited by 1,156MicroRNA in disease regulationMetabolism, Diabetes, and CancerCholesterol and Lipid Metabolism

MicroRNAs in metabolism and metabolic disorders

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Rottiers, Veerle, Näär, Anders M.·2012·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm3313PMC PMC4021399
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Abstract

MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. The discovery of circulating miRNAs has highlighted their potential as both endocrine signalling molecules and disease markers. Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that miRNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.

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Authors
Rottiers, V., & Näär, A. M.
Affiliations
  • Massachusetts General Hospital (US)
  • Harvard University (US)
Corresponding author
Näär, Anders M.
ORCID
Näär, Anders M.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2012-03-22
Volume
13
Issue
4
Pages
239-250
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
DOI
10.1038/nrm3313
PMC
PMC4021399
OpenAlex
W2027744584
Cited by
1,156
References
17
Citations by year
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FWCI
7.33
Type
journal article
Language
en
Update notices
erratum (2012-04-23)
Open access
Licence
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R21DK084459, R01DK094184)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords
microRNA, metabolism, metabolic disorders, miR-33a, miR-33b, SREBP, cholesterol metabolism, lipid metabolism, insulin, glucose homeostasis, miR-103, miR-107, miR-34a, hepatic lipid homeostasis, circulating microRNAs, disease biomarkers, therapeutic target, cardiometabolic disease
MeSH terms
Cholesterol, Endocrine System, Fatty Liver, Glucose, Homeostasis, Humans, Insulin, Metabolic Diseases, Obesity, Signal Transduction, Oligoribonucleotides, Antisense, Metabolic Syndrome, MicroRNAs, Lipid Metabolism, Sterol Regulatory Element Binding Proteins, Non-alcoholic Fatty Liver Disease

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