Revisiting caspases in sepsis

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Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

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A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

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Caspase Functions in Cell Death and DiseasePreprint

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Non-canonical inflammasome activation targets caspase-11

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

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In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

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Molecular mechanisms of necroptosis: an ordered cellular explosion

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Human ICE/CED-3 Protease Nomenclature

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Molecular mechanisms of caspase regulation during apoptosis

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Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

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Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

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Mechanisms of caspase activation

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Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

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Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

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Molecular Cloning of the Interleukin-1β Converting Enzyme

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Caspase‐1‐induced pyroptotic cell death

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Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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Sir Isaac Newton, sepsis, SIRS, and CARS

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Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans

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The protein structures that shape caspase activity, specificity, activation and inhibition

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Inflammatory caspases and inflammasomes: master switches of inflammation

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Apoptosis and caspases regulate death and inflammation in sepsis

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Caspase-independent cell death

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

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RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

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Caspases in cell survival, proliferation and differentiation

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Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.Preprint

Salmena, L., Lemmers, B., Hakem, A., Matysiak-Zablocki, E., Murakami, K., Au, P. Y. B., Berry, D., Tamblyn, L., Shehabeldin, A., Migon, E., et al. (2003) · Genes & Development · doi:10.1101/gad.1063703 · Cited by 517 · see citing works

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

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Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

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Prevention of lymphocyte cell death in sepsis improves survival in mice

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Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

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Requirement for Caspase-8 in NF-κB Activation by Antigen Receptor

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Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

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Recognition of Bacteria by Inflammasomes

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Many stimuli pull the necrotic trigger, an overview

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Overexpression of Bcl-2 in Transgenic Mice Decreases Apoptosis and Improves Survival in Sepsis

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Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

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Accelerated Lymphocyte Death in Sepsis Occurs by both the Death Receptor and Mitochondrial Pathways

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Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice

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The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock

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Specific involvement of caspases in the differentiation of monocytes into macrophages

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IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

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Current trends in inflammatory and immunomodulatory mediators in sepsis

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Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways

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Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

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Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin‐1β

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Neuroprotection by a caspase inhibitor in acute bacterial meningitis

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Caspase-1-Mediated Activation of Interleukin-1β (IL-1β) and IL-18 Contributes to Innate Immune Defenses againstSalmonella entericaSerovar Typhimurium Infection

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The new normal: immunomodulatory agents against sepsis immune suppression

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IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

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Caspase inhibition causes hyperacute tumor necrosis factor–induced shock via oxidative stress and phospholipase A2

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Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

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Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

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Inhibitor of Apoptosis Protein cIAP2 Is Essential for Lipopolysaccharide-Induced Macrophage Survival

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Cutting Edge: Innate Immunity Conferred by B Cells Is Regulated by Caspase-8

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Syncytial fusion of human trophoblast depends on caspase 8

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In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice

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Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity

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Simultaneous Targeting of IL-1 and IL-18 Is Required for Protection against Inflammatory and Septic Shock

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Intravenous TAT–Bcl‐Xl is protective after middle cerebral artery occlusion in mice

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Caspase-1 Regulates Escherichia coli Sepsis and Splenic B Cell Apoptosis Independently of Interleukin-1β and Interleukin-18

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Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity

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Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism

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Akt Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis

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TAT-BH4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo

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Recombinant human MFG-E8 attenuates cerebral ischemic injury: Its role in anti-inflammation and anti-apoptosis

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Milk Fat Globule-Epidermal Growth Factor-Factor 8 Attenuates Neutrophil Infiltration in Acute Lung Injury via Modulation of CXCR2

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Over-Expression of Bcl-2 Provides Protection in Septic Mice by a trans Effect

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Improved survival in experimental sepsis with an orally administered inhibitor of apoptosis

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Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia

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Novel Therapeutic Targets for Sepsis: Regulation of Exaggerated Inflammatory Responses

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Increased inducible apoptosis in CD4+ T lymphocytes during polymicrobial sepsis is mediated by Fas ligand and not endotoxin

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Caspase Activity Is Required for Stimulated B Lymphocytes to Enter the Cell Cycle

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Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival

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Protease-activated Nanomaterials for Targeted Cancer Theranostics

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A Systematic Review of Nonclinical Studies on the Effect of Curcumin in Chemotherapy- induced Cardiotoxicity

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Research progress on the role of mesenchymal stem cells in pyroptosis in sepsis

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