Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis

Mitochondrial membrane permeabilization in cell death

Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

Shimizu, S., Narita, M., Tsujimoto, Y., & Tsujimoto, Y. (1999) · Nature · doi:10.1038/20959 · Cited by 2,178

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., & Green, D. R. (2004) · Science · doi:10.1126/science.1092734 · Cited by 2,108

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631

Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

Bernardi, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1127 · Cited by 1,546

Reactive Oxygen Species (Ros-Induced) Ros Release

Zorov, D. B., Filburn, C. R., Klotz, L.-O., Zweier, J. L., & Sollott, S. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1001 · Cited by 1,412

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

Goldstein, J. C., Waterhouse, N. J., Juin, P. P., Evan, G. I., & Green, D. R. (2000) · Nature Cell Biology · doi:10.1038/35004029 · Cited by 1,073

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

Baines, C. P., Kaiser, R. A., Sheiko, T., Craigen, W. J., & Molkentin, J. D. (2007) · Nature Cell Biology · doi:10.1038/ncb1575 · Cited by 971

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol

Han, D., Antunes, F., Canali, R., Rettori, D., & Cadenas, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210269200 · Cited by 711

PE-induced apoptosis in SMMC-7721 cells: Involvement of Erk and Stat signalling pathways

Li, X., Li, M., Chen, T., Sun, H., Zhu, J., Li, X., WU, F., Wang, B., Li, J., & Chen, Y. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1777 · Cited by 15

Unraveling the role of high-intensity resistance training on left ventricle proteome: Is there a shift towards maladaptation?

Dantas, P. S., Sakata, M. M., Perez, J. D., Watanabe, R. L. H., Bizerra, F. C., das Neves, V. J., Guzzoni, V., Marcondes, F. K., Casarini, D. E., & Cunha, T. S. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.03.040 · Cited by 14

Folded Structure and Membrane Affinity of the N-Terminal Domain of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion-Selective Channel

Manzo, G., Serra, I., Magrì, A., Casu, M., Pinto, V. D., Ceccarelli, M., & Scorciapino, M. A. (2018) · ACS Omega · doi:10.1021/acsomega.8b01536 · Cited by 12

Small-Molecule Modulators of Mitochondrial Channels as Chemotherapeutic Agents

Parrasia, S., Mattarei, A., Furlan, A., Zoratti, M., & Biasutto, L. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000192 · Cited by 12

Serum and glucocorticoid-regulated kinase 1 (SGK1) as an emerging therapeutic target for cardiac diseases

Yarmohammadi, F., & Karimi, G. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107369 · Cited by 11

Glucose‐6‐phosphate tips the balance in modulating apoptosis in cerebellar granule cells

Bobba, A., Amadoro, G., Piana, G. L., Petragallo, V. A., Calissano, P., & Atlante, A. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.01.031 · Cited by 13

Cell death in HeLa mediated by thermoplastic polyurethane with co-immobilized IFN-γ plus TNF-α

Guan, Y., Zheng, Z., Li, Z., & Liu, J. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.11.023 · Cited by 10

In vitro and in vivo anticancer potential and molecular targets of the new colchicine analog IIIM-067

Malik, S., Mintoo, M. J., Reddy, C. N., Kumar, R., Kotwal, P., Bharate, S. B., Nandi, U., Mondhe, D. M., & Shukla, S. K. (2022) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2022.09.006 · Cited by 9

Cell signaling and cancer‐possible targets for therapy

Wenner, C. E. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22021 · Cited by 9

Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury

Shi, Y., He, T., Liu, H., Li, X., Li, Z., Wen, Q., Dai, Z.-H., Sun, X., Tan, Q., Yang, W., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.97106 · Cited by 9

Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone

Zhang, L., Townsend, D. M., Morris, M. E., Maldonado, E. N., Jiang, Y.-L., Broome, A., Bethard, J. R., Ball, L. E., & Tew, K. D. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.000009 · Cited by 9

Bisindolylpyrrole triggers transient mitochondrial permeability transitions to cause apoptosis in a VDAC1/2 and cyclophilin D-dependent manner via the ANT-associated pore

Koushi, M., Aoyama, Y., Kamei, Y., & Asakai, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-73667-z · Cited by 8

ECM stiffness regulates calcium influx into mitochondria via tubulin and VDAC1 activity

Kim, M., Han, K., Choi, G., Ahn, S.-H., Suh, J., & Kim, T. (2024) · Animal Cells and Systems · doi:10.1080/19768354.2024.2393811 · Cited by 7

Green synthesis of copper oxide nanoparticles using Ficus pumila and their multifunctional biomedical and environmental applications

Muthalagu, S., MohamedAsik, A., Selvaraj, M., Assiri, M. A., & Suganthy, N. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.109272 · Cited by 7

Mitochondrial Regulation of Cell Death

Liu, D., Perfettini, J., & Brenner, C. (2018) · Springer eBooks · doi:10.1007/978-3-319-73344-9_6 · Cited by 8

Isolation and Metabolic Assessment of Cancer Cell Mitochondria

Long, N. P., Min, J. E., Anh, N. H., Kim, S. J., Park, S., Kim, H. M., Yoon, S. J., Lim, J., Lee, S. J., & Kwon, S. W. (2020) · ACS Omega · doi:10.1021/acsomega.0c03612 · Cited by 7

Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise

Ma, J., Son, A. Y., Son, Y., Wang, P., & Hwang, P. M. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.05.004 · Cited by 6

TSPO, reactive oxygen species and oxidative stress in physiological and pathological situations: a complex relationship

Morin, D., & Lacapère, J.-J. (2025) · Biochimie · doi:10.1016/j.biochi.2025.08.002 · Cited by 7

Cyclophilin‐D is dispensable for atrophy and mitochondrial apoptotic signalling in denervated muscle

Daussin, F., Godin, R., Ascah, A., Deschênes, S., & Burelle, Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.202036 · Cited by 6

Diet Restriction Impact on High-Fat-Diet-Induced Obesity by Regulating Mitochondrial Cardiolipin Biosynthesis and Remodeling

Li, Q., Lin, Y., Xu, J., Liu, Y., Jing, Y., Huang, R., Song, C., Zhang, L., & Jin, S. (2023) · Molecules · doi:10.3390/molecules28114522 · Cited by 5

Association between Mitochondrial Bioenergetics and Radiation- Related Fatigue: A Possible Mechanism and Novel Target

Hsiao, C. P. (2015) · Archives in Cancer Research · doi:10.21767/2254-6081.100014 · Cited by 5

GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice

Huot, J. R., Jamnick, N. A., Pin, F., Livingston, P. D., Callaway, C. S., Morrow, S. K., & Bonetto, A. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00035.2025 · Cited by 4

Role of voltage-dependent anion channel 1 in neurodegeneration: Mechanisms, implications, and therapeutic potential

Parikh, A., Cholavaram, A. S., Babu, A. K. C., Deepankumar, K., & Vijayan, M. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00368 · Cited by 4

Attenuation of Equine Lentivirus Alters Mitochondrial Protein Expression Profile from Inflammation to Apoptosis

Du, C., Duan, Y., Wang, X., Lin, Y., Lei, N., Wang, X., Chen, K., & Wang, X. (2019) · Journal of Virology · doi:10.1128/jvi.00653-19 · Cited by 4

Modulation of mitochondrial voltage dependent anion channel: studies on bilayer electrophysiology

Koren, D. T., Malik, C., Siddiqui, S. I., Shrivastava, R., & Ghosh, S. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1666994 · Cited by 3

HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Metabolism and Cell Fate

Pesce, N. A., Seminara, G., Giarrusso, G., & Tomasello, M. F. (2025) · Advanced Biology · doi:10.1002/adbi.202500472 · Cited by 3

Disruption of sphingolipid metabolism triggers lung vascular inflammation and aging-like changes under hypoxia through VDAC1-mediated mitochondrial DNA release

Xu, J., Ge, Y., Zhang, B., He, S., Cao, Q.-L., Li, P., Bu, Y.-R., Bai, Y., Zhang, L., Tan, G., et al. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02296-0 · Cited by 3

Characterization and Functional Analysis of Voltage‐Dependent Anion Channel 1 (VDAC1) from Orange‐Spotted Grouper (Epinephelus coioides)

Shi, Y., Zhao, Z., Hong, X., Chen, K., & Zhu, X. (2014) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21565 · Cited by 3

PA1b-like peptides alleviate mitochondrial dysfunction induced by glucose toxicity through interaction with VDAC1 in β-cells

Huang, H., Zeng, X., Zhang, L., Cheng, H., Hu, K., Shang, X., & Yao, C. (2025) · Food & Function · doi:10.1039/d5fo00054h · Cited by 2

VEGF and the VEGF73-101 Fragment Prevent MPP+ Induced Mitochondrial Dysfunction in a Cell Model of Parkinson’s Disease

Zimbone, S., Battiato, G., Nibali, S. C., Николаевна, Н. И., Pesce, N. A., Pinto, V. D., Messina, A. A., Magrì, A., Tomasello, M. F., & Grasso, G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05213-9 · Cited by 2

From gatekeepers to mitochondrial mischief: how bacterial outer membrane proteins crash the host cell party

Osset-Trénor, P., Proft, M., & Pascual‐Ahuir, A. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf062 · Cited by 2

Cytopathic BVDV engages VDAC1 through NS3 to trigger mitochondrial permeability transition–dependent intrinsic apoptosis

Zhang, X., Chang, L., Sun, Y., Zhang, H., Haoxiang, Z., Ma, L., Ma, X., Tong, D., & Zhao, X. (2026) · Veterinary Microbiology · doi:10.1016/j.vetmic.2026.111069 · Cited by 2

Effect of maternal cigarette smoke exposure on COPD progression in offspring mice

Sun, J., Chen, H., Xu, X., Dou, Y., Wu, B., Zhang, H., Shang, S., & Sun, W. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108646 · Cited by 1

Rafoxanide disrupts mitochondrial homeostasis through VDAC1 modulation in colorectal cancer cells

Tomassini, L., Pacifico, T., Serra, M. A., Sommella, E., Sambucci, M., Sica, G. S., Savino, L., Vitale, S., Ortenzi, A., Biancone, L., et al. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-02986-3 · Cited by 1

Hepatoprotective Effects of Imeglimin Are Associated With Preserved Mitochondrial Bioenergetics and Reduced Oxidative Stress in a Murine Cholestasis Model

Goto, H., Suda, K., Yasukawa, T., Fujimoto, T., Rao, X., Tsunoda, Y., Hida, M., Meng, X., Piao, C., Zhang, J., et al. (2026) · Hepatology Research · doi:10.1111/hepr.70258 · Cited by 1

PolyQ-expanded ataxin-3 is associated with mitochondrial alterations in Machado–Joseph disease

Simó, I., Robinson, K. J., Kam, J. Y., Wang, Y., Kuriakose, A., Parić, E., Cheng, F., Potapenko, A., An, Y., Watchon, M., et al. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052757 · Cited by 1

Plant VDAC Permeability: Molecular Basis and Role in Oxidative Stress

Homblé, F., Kmita, H., Saidani, H., & Léonetti, M. (2017) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-319-55539-3_7 · Cited by 1

High‐Throughput Flow Cytometry Analysis of Apoptosis

Giorgi, F. D., & Ichas, F. (2013) · doi:10.1002/9781118538203.ch6 · Cited by 1

Evaluating the anti-leukemia activity of avocatin B

Lee, E. A. (2015) · UWSpace (University of Waterloo) · Cited by 1

Self-Assembling Synthetic Peptides Remodel Mitochondrial Properties via Nanopore FormationPreprint

Nguyen, N., Fujita, S., Takeuchi, N., Kawano, R., & Inoue, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.26.672490 · Cited by 1

Hepatocyte Apoptosis at the Interplay of Intracellular Organelles and Membrane-Bound Receptors: Targets for Therapy

Karimian, G., & Faber, K. N. (2012) · Clinical and Experimental Pharmacology · doi:10.4172/2161-1459.s3-002

The role of the mitochondrial permeability transition pore in human myocardial protection

Shanmuganathan, S. (2015) · UCL Discovery (University College London)

THE PROSURVIVAL ACTIVITIES OF APOPTOSIS-INDUCING FACTOR CONVERGE UPON THE REGULATION OF MITOCHONDRIAL METABOLISM, A NOVEL CELL DEATH PATHWAY, AND THE PROGRESSION OF PROSTATE CANCER

Lenhausen, A. M. (2013) · WakeSpace Scholarship (Wake Forest University)

Faculty Opinions recommendation of Mitochondrial permeability uncouples elevated autophagy and lifespan extension.

Friedman, D. J., & Shah, S. S. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735403474.793565712

Faculty Opinions recommendation of Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS.

Rouleau, G. A. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.12801959.14078059

Faculty Opinions recommendation of Mitochondrial permeability uncouples elevated autophagy and lifespan extension.

Schumacher, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735403474.793563330

Faculty Opinions recommendation of Mitochondrial permeability uncouples elevated autophagy and lifespan extension.

Nyathi, Y. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735403474.793566076

Shedding of mitochondrial Voltage-Dependent Anion Channel-1 (VDAC1) Reflects COVID-19 Severity and Reveals Macrophage DysfunctionPreprint

Sjögren, M., Dunér, P., Marinis, Y. Z. D., Neumann, A., Leandersson, K., Rasmussen, M., Wollheim, C. B., & Salehi, A. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.07.663218

VDAC1: at the crossroads of cancer signalling and metabolism

Choudhari, M., Taunk, K., Kalita, B., & Rapole, S. (2025) · Expert Review of Proteomics · doi:10.1080/14789450.2025.2607512

Synthèse asymétrique de l’épi-jasmonate de méthyle et de son énantiomère (ent-épi-jasmonate de méthyle) par voie chimique et enzymatique

Deau, E. (2011) · theses.fr (ABES) · doi:10.70675/2507541ezfdaaz4b2fzb15az4676f0f05e81

Lésions d'ischémie-reperfusion myocardiques : régulation de la transition de perméabilité et rôle de l'activation de l'inflammation locale et systémique

Bochaton, T. (2016) · theses.fr (ABES) · doi:10.70675/07ba3facze6fcz4d4cz93d1z8feb45c4022a

Target and small molecule discovery for therapeutic innovation in cardiovascular area

Liu, D. (2019) · theses.fr (ABES) · doi:10.70675/da9fa152zdcc0z498dz9194z563d22d0b77c

Rôles des régulateurs de l’apoptose Bcl-wav et Nrz, au cours du développement embryonnaire du poisson zèbre

Prudent, J. (2011) · theses.fr (ABES) · doi:10.70675/1f03460cze5d6z42c6za18ez352e34a4dee4

Laser powder bed fusion of zinc-based biomaterials: Process-microstructure-property relationships for biomedical applications

Nigam, A., Powar, S., Balan, A. S. S., & Doddamani, M. R. (2026) · Additive Manufacturing Frontiers · doi:10.1016/j.amf.2026.200343

Disruption of Fructose 1,6-Bisphosphatase 2 Proximity to MIC60 Correlates with Mitochondrial Ultrastructural Changes

Pietras, Ł., Migocka-Patrzałek, M., Budziak, B., Rakus, D., & Gizak, A. (2026) · Cells · doi:10.3390/cells15100942

Induction of mitochondrial fission and mtDNA leakage via the Smad3/Drp1 axis by PEDV infection activates the TLR9/NF-κB/IL-1β inflammatory pathway

Xie, H., Guan, J.-L., Tian, F., Xiong, T., Feng, H., Xu, F., zhou, Z., 贺东生, Liu, D. X., & Chen, R. (2026) · Virologica Sinica · doi:10.1016/j.virs.2026.05.004

Allosteric activation of Trx1 by antagonizing nitrative modification at tyrosine 49 confers neuroprotection against ischemic stroke

Guo, M., Guo, H., Ren, W., Wang, X., Wang, X., (4829), Y. L., Kong, W., & Guo, Q. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104246

Delphinidin targets voltage-dependent anion channel 1 to inhibit ferroptosis and protect against retinal photochemical damage

Wang, H., Li, K., Pu, H., Xiong, Y., Luo, D., Song, J., Jiang, H., Yu, X., & Deng, T. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158455

Effects of magnesium ions on the physicochemical properties of a model outer mitochondrial membrane in cytosol mimic conditions

Michaluk, P., Szuniewicz, K., Mierzejewska, M., Sęk, S., & Dziubak, D. (2026) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2026.109492

Characterizing the Role of HspB2 in Cardiac Metabolism and Muscle Structure Using Yeast and Mammalian Systems

Neubert, J. P. (2012) · ScholarsArchive (Brigham Young University)

THE EFFECT OF INSULIN ON STRESS-RESPONSE PATHWAYS IN A CELLULAR MODEL OF RAT CARDIOMYOCYTES

Jones, Q. R. D. (2011) · Library and Archives Canada (Government of Canada)

The role of VDAC in cell death: Friend or foe?

McCommis, K. S., & Baines, C. P. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.10.025 · Cited by 150

The voltage-dependent anion channel: an essential player in apoptosis

Tsujimoto, Y., & Shimizu, S. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01370-6 · Cited by 249

The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death

Granville, D. J., & Gottlieb, R. A. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033457214 · Cited by 58

VDAC2 is required for truncated BID‐induced mitochondrial apoptosis by recruiting BAK to the mitochondria

Roy, S. S., Ehrlich, A. M., Craigen, W. J., & Hajnóczky, G. (2009) · EMBO Reports · doi:10.1038/embor.2009.219 · Cited by 150

The Role of Mitochondria in Apoptosis

Tang, Z. (2006) · Progress in Veterinary Medicine · Cited by 1