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Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

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Is mPTP the gatekeeper for necrosis, apoptosis, or both?

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VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria

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Mitochondrial Channels: Ion Fluxes and More

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Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

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The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore

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Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis

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VDAC, a multi-functional mitochondrial protein as a pharmacological target

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The mitochondrial voltage-dependent anion channel 1 in tumor cells

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VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases

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Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

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VDAC1: from structure to cancer therapy

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Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

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Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress

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VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress

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Characterization of human VDAC isoforms: A peculiar function for VDAC3?

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VDAC1 functions in Ca2+ homeostasis and cell life and death in health and disease

Shoshan‐Barmatz, V., Krelin, Y., & Shteinfer‐Kuzmine, A. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.06.007 · Cited by 165

Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo

Shoshan‐Barmatz, V., Keinan, N., Abu‐Hamad, S., Tyomkin, D., & Aram, L. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.03.003 · Cited by 155

Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy

Shoshan‐Barmatz, V., & Golan, M. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712798992110 · Cited by 142

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca2+ Transport, Apoptosis, and Their Regulation

Shoshan‐Barmatz, V., De, S., & Meir, A. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00060 · Cited by 127

Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity

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Cyclophilin D Deficiency Rescues Axonal Mitochondrial Transport in Alzheimer’s Neurons

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Ca2+-mediated regulation of VDAC1 expression levels is associated with cell death induction

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The mitochondrial permeability transition: Nexus of aging, disease and longevity

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VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications

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The role of mitophagy in innate immune responses triggered by mitochondrial stress

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Mitochondrial ion channels as oncological targets

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Oligomerization of the Mitochondrial Protein VDAC1

Shoshan‐Barmatz, V., Mizrachi, D., & Keinan, N. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386931-9.00011-8 · Cited by 91

Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives

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Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway

Leone, A., Roca, M. S., Ciardiello, C., Terranova-Barberio, M., Vitagliano, C., Ciliberto, G., Mancini, R., Gennaro, E. D., Bruzzese, F., & Budillon, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.155 · Cited by 84

Reactive oxygen species‐provoked mitochondria‐dependent cell death during ageing of elm (Ulmus pumila L.) seeds

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Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress

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Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism

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The Voltage-Dependent Anion Selective Channel 1 (VDAC1) Topography in the Mitochondrial Outer Membrane as Detected in Intact Cell

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Hexokinase I N-terminal based peptide prevents the VDAC1-SOD1 G93A interaction and re-establishes ALS cell viability

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Autoantibody-Specific Signalling in Pemphigus

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Structural basis of complex formation between mitochondrial anion channel VDAC1 and Hexokinase-II

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Mitochondria: Novel Mechanisms and Therapeutic Targets for Secondary Brain Injury After Intracerebral Hemorrhage

Chen, W., Guo, C., Feng, H., & Chen, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.615451 · Cited by 64

Inhibition of VDAC1 prevents Ca2+-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages

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Role of microRNA in metabolic shift during heart failure

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An iTRAQ-based mitoproteomics approach for profiling the nephrotoxicity mechanisms of ochratoxin A in HEK 293 cells

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Organophosphorus flame retardant TDCPP induces neurotoxicity via mitophagy-related ferroptosis in vivo and in vitro

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Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast

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IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF‐κB retention

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Charged Residues Distribution Modulates Selectivity of the Open State of Human Isoforms of the Voltage Dependent Anion-Selective Channel

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Hyperglycemia-induced oxidative stress exacerbates mitochondrial apoptosis damage to cochlear stria vascularis pericytes via the ROS-mediated Bcl-2/CytC/AIF pathway

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Cell apoptosis induced by zinc deficiency in osteoblastic MC3T3-E1 cells via a mitochondrial-mediated pathway

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VDAC1 cysteine residues: topology and function in channel activity and apoptosis

Aram, L., Geula, S., Arbel, N., & Shoshan‐Barmatz, V. (2010) · Biochemical Journal · doi:10.1042/bj20091690 · Cited by 48

miR-197-3p Represses the Proliferation of Prostate Cancer by Regulating the VDAC1/AKT/β-catenin Signaling Axis

Huang, Q., Ma, B., Su, Y., Chan, K., Qu, H., Huang, J., Wang, D., Qiu, J., Liu, H., Yang, X., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.42019 · Cited by 45

Characterization of Functional Reprogramming during Osteoclast Development Using Quantitative Proteomics and mRNA Profiling

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Deletion of β-strands 9 and 10 converts VDAC1 voltage-dependence in an asymmetrical process

Reina, S., Magrì, A., Lolicato, M., Guarino, F., Impellizzeri, A. A. R., Maier, E., Benz, R., Ceccarelli, M., Pinto, V. D., & Messina, A. A. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.03.007 · Cited by 41

Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells

Koul, M., Kumar, A., Deshidi, R., Sharma, V., Singh, R. D., Singh, J., Sharma, P. R., Shah, B. A., Jaglan, S., & Singh, S. K. (2017) · BMC Cell Biology · doi:10.1186/s12860-017-0141-0 · Cited by 40

Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells

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Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury

Ghio, A. J., Soukup, J. M., Dailey, L. A., & Madden, M. C. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.007 · Cited by 39

MAP4 Mechanism that Stabilizes Mitochondrial Permeability Transition in Hypoxia: Microtubule Enhancement and DYNLT1 Interaction with VDAC1

Fang, Y.-D., Xu, X., Dang, Y.-M., Zhang, Y., Zhang, J.-P., Hu, J., Zhang, Q., Dai, X., Teng, M., Zhang, D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028052 · Cited by 40

Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage‐dependent anion channel‐1

Joo, H. K., Lee, Y. R., Lim, S., Lee, E. J., Choi, S., Cho, E., Park, M. S., Ryoo, S., Park, J. B., & Jeon, B. H. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.03.049 · Cited by 38

Zinc Protects Human Kidney Cells from Depleted Uranium‐induced Apoptosis

Hao, Y., Ren, J., Liu, C., Li, H., Liu, J., Yang, Z., Li, R., & Su, Y. (2013) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12167 · Cited by 38

Communication between mitochondria and nucleus: Putative role for VDAC in reduction/oxidation mechanism

Gałgańska, H., Karachitos, A., Wojtkowska, M., Stobienia, O., Budzińska, M., & Kmita, H. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.02.004 · Cited by 40

Sequestration of mitochondrial iron by silica particle initiates a biological effect

Ghio, A. J., Tong, H., Soukup, J. M., Dailey, L. A., Cheng, W.-Y., Samet, J. M., Kesic, M. J., Bromberg, P. A., Turi, J. L., Upadhyay, D., et al. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00099.2013 · Cited by 37

Translocator Protein (TSPO) in Breast Cancer

Mukherjee, S., & Das, S. (2012) · Current Molecular Medicine · doi:10.2174/1566524011207040443 · Cited by 38

Apoptosis Inducing Factor Binding Protein PGAM5 Triggers Mitophagic Cell Death That Is Inhibited by the Ubiquitin Ligase Activity of X-Linked Inhibitor of Apoptosis

Lenhausen, A. M., Wilkinson, A. S., Lewis, E. M., Dailey, K. M., Scott, A. J., Khan, S., & Wilkinson, J. C. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00306 · Cited by 37

Molecular Mechanisms of Perfluorooctanoate-Induced Hepatocyte Apoptosis in Mice Using Proteomic Techniques

Li, K., Sun, J., Yang, J., Roberts, S. M., Zhang, X., Cui, X., Wei, S., & Ma, L. Q. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b02690 · Cited by 33

Mitochondrion-Dependent Cell Death in TDP-43 Proteinopathies

Lucini, C. B., & Braun, R. J. (2021) · Biomedicines · doi:10.3390/biomedicines9040376 · Cited by 34

Differential Expression of Genes Related to Mitochondrial Biogenesis and Bioenergetics in Fatigued Prostate Cancer Men Receiving External Beam Radiation Therapy

Hsiao, C., Wang, D., Kaushal, A., Chen, M., & Saligan, L. N. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2014.03.010 · Cited by 33

External mitochondrial NADH-dependent reductase of redox cyclers: VDAC1 or Cyb5R3?

Nikiforova, A. B., Saris, N.-E. L., & Kruglov, A. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.06.005 · Cited by 33

E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson’s Disease model

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VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration

Argueti-Ostrovsky, S., Barel, S., Kahn, J., & Israelson, A. (2024) · Biomolecules · doi:10.3390/biom15010033 · Cited by 31

A novel colchicine-based microtubule inhibitor exhibits potent antitumor activity by inducing mitochondrial mediated apoptosis in MIA PaCa-2 pancreatic cancer cells

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The Potential Role of Voltage‐Dependent Anion Channel in the Treatment of Parkinson’s Disease

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A proteomic approach to study parathyroid glands

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The Influence of MicroRNAs on Mitochondrial Calcium

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Targeting mitochondrial impairment for the treatment of cardiovascular diseases: From hypertension to ischemia-reperfusion injury, searching for new pharmacological targets

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Ethyl Acetate Extract of Colletotrichum gloeosporioides Promotes Cytotoxicity and Apoptosis in Human Breast Cancer Cells

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iTRAQ Mitoproteome Analysis Reveals Mechanisms of Programmed Cell Death in Arabidopsis thaliana Induced by Ochratoxin A

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The ER-mitochondria Ca2+ signaling in cancer progression: Fueling the monster

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The 18-kDa Translocator Protein Inhibits Vascular Cell Adhesion Molecule-1 Expression via Inhibition of Mitochondrial Reactive Oxygen Species

Joo, H. K., Lee, Y. R., Kang, G., Choi, S., Kim, C., Ryoo, S., Park, J. B., & Jeon, B. H. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0165 · Cited by 28

Neuroglobin and friends

Fiocchetti, M., Cipolletti, M., Brandi, V., Polticelli, F., & Ascenzi, P. (2017) · Journal of Molecular Recognition · doi:10.1002/jmr.2654 · Cited by 28

CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice

Hseu, Y., Thiyagarajan, V., Ou, T., & Yang, H. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2050-6 · Cited by 28

Hydrogen-rich saline protects rat from oxygen glucose deprivation and reperusion-induced apoptosis through VDAC1 via Bcl-2

Mo, X., Li, X., She, C., Lu, X., Xiao, C., Wang, S.-H., & Huang, G. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.037 · Cited by 27

Picroside II Exerts a Neuroprotective Effect by Inhibiting mPTP Permeability and EndoG Release after Cerebral Ischemia/Reperfusion Injury in Rats

Li, S., Wang, T., Zhai, L., Ge, K., Zhao, J., Cong, W., & Guo, Y. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-1012-z · Cited by 26

Live cell interactome of the human voltage dependent anion channel 3 (VDAC3) revealed in HeLa cells by affinity purification tag technique

Messina, A. A., Reina, S., Guarino, F., Magrì, A., Tomasello, M. F., Clark, R. E., Ramsay, R. R., & Pinto, V. D. (2014) · Molecular BioSystems · doi:10.1039/c4mb00237g · Cited by 26

News about VDAC1 in Hypoxia

Mazure, N. M. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00193 · Cited by 25

Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1

Li, D., & Vaux, D. L. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2599-5 · Cited by 24

The release of cytochrome c and the regulation of the programmed cell death progress in the endosperm of winter wheat (Triticum aestivum L.) under waterlogging

Qi, Y., Mao, F.-F., Zhou, Z.-Q., Liu, D., MinYU, Deng, X., Li, J., & Mei, F. (2018) · PROTOPLASMA · doi:10.1007/s00709-018-1256-7 · Cited by 24

Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions

Rosa, M. C. D., Guarino, F., Nibali, S. C., Magrì, A., & Pinto, V. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.675708 · Cited by 21

The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities.

Guardiani, C., Scorciapino, M. A., Amodeo, G., Grdadolnik, J., Pappalardo, G., Pinto, V. D., Ceccarelli, M., & Casu, M. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00469 · Cited by 20

MIRO‐1 interacts with VDAC‐1 to regulate mitochondrial membrane potential in Caenorhabditis elegans

Ren, X., Zhou, H., Sun, Y., Fu, H., Ran, Y., Yang, B., Yang, F., Björklund, M., & Xu, S. (2023) · EMBO Reports · doi:10.15252/embr.202256297 · Cited by 19

Age and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity

Louwagie, E. J., Larsen, T. D., Wachal, A. L., Gandy, T. C. T., Eclov, J. A., Rideout, T. C., Kern, K. A., Cain, J. T., Anderson, R. H., Mdaki, K. S., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101746 · Cited by 20

Iron diminishes the in vitro biological effect of vanadium

Ghio, A. J., Stonehuerner, J., Soukup, J. M., Dailey, L. A., Kesic, M. J., & Cohen, M. D. (2015) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2015.03.008 · Cited by 19

A sustainable and nondestructive method to high-throughput decolor Lycium barbarum L. polysaccharides by graphene-based nano-decoloration

Shi, S., Zhang, W., Liu, X., Ren, X., Li, M., Sun, J., Wang, Y., Yue, T., & Wang, J. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127749 · Cited by 18

Mitochondrial α7 nicotinic acetylcholine receptors are displaced from complexes with VDAC1 to form complexes with Bax upon apoptosis induction

Kalashnyk, O., Lykhmus, O., Uspenska, K., Izmailov, M., Комісаренко, С. В., & Skok, M. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105879 · Cited by 18

Central role of RIPK1-VDAC1 pathway on cardiac impairment in a non-human primate model of rheumatoid arthritis

Zeng, F., Wen, W., Cui, W., Zheng, W., Liu, Y., Sun, X., Hou, N., Ma, D., Yuan, Y., Shi, H., et al. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.10.015 · Cited by 16

Mechanism of translation control of the alternative Drosophila melanogaster Voltage Dependent Anion-selective Channel 1 mRNAs

Leggio, L., Guarino, F., Magrì, A., Accardi, R., Reina, S., Specchia, V., Damiano, F., Tomasello, M. F., Tommasino, M., & Messina, A. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-23730-7 · Cited by 17

Sweet as honey, bitter as bile: Mitochondriotoxic peptides and other therapeutic proteins isolated from animal tissues, for dealing with mitochondrial apoptosis

Colella, F., Scillitani, G., & Pierri, C. L. (2020) · Toxicology · doi:10.1016/j.tox.2020.152612 · Cited by 17

Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

Sekigawa, A., Fujita, M., Sekiyama, K., Takamatsu, Y., Hatano, T., Rockenstein, E. M., Spada, A. R. L., Masliah, E., & Hashimoto, M. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-34 · Cited by 15

The role of VDAC in cell death: Friend or foe?

McCommis, K. S., & Baines, C. P. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.10.025 · Cited by 150

The voltage-dependent anion channel: an essential player in apoptosis

Tsujimoto, Y., & Shimizu, S. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01370-6 · Cited by 249

The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death

Granville, D. J., & Gottlieb, R. A. (2003) · Current Medicinal Chemistry · doi:10.2174/0929867033457214 · Cited by 58

VDAC2 is required for truncated BID‐induced mitochondrial apoptosis by recruiting BAK to the mitochondria

Roy, S. S., Ehrlich, A. M., Craigen, W. J., & Hajnóczky, G. (2009) · EMBO Reports · doi:10.1038/embor.2009.219 · Cited by 150

The Role of Mitochondria in Apoptosis

Tang, Z. (2006) · Progress in Veterinary Medicine · Cited by 1