Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling
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SAHPA1 and xStAx are capable of penetrating the cell membrane and binding with β-catenin.
“Both SAHPA1 and xStAx are capable of penetrating the cell membrane and binding with β-catenin.”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [13]
In the Dear Editor section (page not available), the paper reports that SAHPA1 binds β-catenin and that FITC-labeled SAHPA1 enters the cytoplasm of HeLa cells. It does not identify a peptide called xStAx or establish both properties for it; it discusses a different peptide, fStAx-35R. (LLM, conf=0.87)
Experimental — accuracy not yet measuredxStAx inhibits Wnt/β-catenin signaling.
“SAHPA1 was shown to activate Wnt/β-catenin signaling, while xStAx inhibited it13,14.”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [13]
SAHPA1 activates Wnt/β-catenin signaling.
“SAHPA1 was shown to activate Wnt/β-catenin signaling, while xStAx inhibited it13,14.”
From A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer (2020) · cites this paper as [13]
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- Authors
- Cui, H.-K., Zhao, B., Li, Y., Guo, Y., Hu, H., Liu, L., & Chen, Y.-G.
- Affiliations
- Center for Life Sciences (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Liu, Lei
- Chen, Ye-Guang
- Venue
- Cell Research
- Published
- 2013-02-26
- Volume
- 23
- Issue
- 4
- Pages
- 581-584
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3616433
- OpenAlex
- W2039188214
- Cited by
- 42
- References
- 14
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 5
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (973 Program, 30930050, 2011CB943803, 30921004)
- Tsinghua University
- Xiamen University
- National Key Research and Development Program of China (2011CB943803, 2011CB965300)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- Wnt/β-catenin signaling, hydrocarbon-stapled peptides, β-catenin stabilization, Wnt agonist, protein-protein interaction disruption, armadillo repeats, cell-permeable peptide, stem cell self-renewal, tissue regeneration
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, HeLa Cells, Humans, Models, Molecular, Molecular Sequence Data, Peptides, Protein Binding, Signal Transduction, Wnt Proteins, beta Catenin, Mice, Embryonic Stem Cells, HEK293 Cells, Axin Protein
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