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Interactions of Amphipathic CPPs with Model Membranes

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Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges

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Cell Penetrating Peptides as Molecular Carriers for Anti-Cancer Agents

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Stapled Helical Peptides Bearing Different Anchoring Residues

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Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area

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A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer

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Emerging Methods and Design Principles for Cell‐Penetrant Peptides

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Is β-Catenin a Druggable Target for Cancer Therapy?

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Direct targeting of β ‐catenin in the Wnt signaling pathway: Current progress and perspectives

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Targeting intracellular protein–protein interactions with macrocyclic peptides

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Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

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Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors

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Targeting the β-catenin signaling for cancer therapy

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Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro

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Enhancing the Cell Permeability of Stapled Peptides with a Cyclic Cell-Penetrating Peptide

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Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System

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Selection of Nucleotide-Encoded Mass Libraries of Macrocyclic Peptides for Inaccessible Drug Targets

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The Therapeutic Potential of PTEN Modulation: Targeting Strategies from Gene to Protein

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Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

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Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε

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Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling

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Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library

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Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins

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Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides

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Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification

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Peptide‐based covalent inhibitors of protein–protein interactions

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Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer

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β-catenin inhibitors in cancer therapeutics: intricacies and way forward

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De novo designed peptides for cellular delivery and subcellular localisation

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Linear and Rationally Designed Stapled Peptides Abrogate TLR4 Pathway and Relieve Inflammatory Symptoms in Rheumatoid Arthritis Rat Model

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Peptides as a Material Platform for Gene Delivery: Emerging Concepts and Converging Technologies

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Revolutionizing Molecular Design for Innovative Therapeutic Applications through Artificial Intelligence

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Photoswitching of Cell Penetration of Amphipathic Peptides by Control of α-Helical Conformation

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Targeting Transcription Factors in Cancer: From “Undruggable” to “Druggable”

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Recent structural advances in constrained helical peptides

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Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors

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Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules

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Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods

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Covalent and Noncovalent Targeting of the Tcf4/β-Catenin Strand Interface with β-Hairpin Mimics

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WNT signaling in cancer: molecular mechanisms and potential therapies

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An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

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Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction

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Constrained peptides mimic a viral suppressor of RNA silencing

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Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 (cemp1-p4) Promotes Mineralization through wnt/β-catenin Signaling in Human Oral Mucosa Stem Cells

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Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor

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Neue Methoden und Designprinzipien für zellgängige Peptide

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Native mass spectrometry of complexes formed by molecular glues reveals stoichiometric rearrangement of E3 ligases

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Targeting and therapeutic peptide-based strategies for polycystic kidney disease

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Stapling of Peptides Potentiates the Antibiotic Treatment of Acinetobacter baumannii In Vivo

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Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf

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Late-stage construction of stapled peptides through Fujiwara–Moritani reaction between tryptophan and olefins

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Guanidinium‐Stapled Helical Peptides for Targeting Protein‐Protein Interactions

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Peptide stapling with the retention of double native side-chains

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Medicinal Chemistry Strategies for the Development of Inhibitors Disrupting β-Catenin’s Interactions with Its Nuclear Partners

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Targeting Oncogenic WNT Signalling with WNT Signalling-Derived Peptides

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A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection

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Peptide Based Inhibitors of Protein Binding to the Mitogen-Activated Protein Kinase Docking Groove

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Identification of an H-Ras nanocluster disrupting peptide

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Design, Synthesis, and Biological Evaluation of Lysine-Stapled Peptide Inhibitors of p53-MDM2/MDMX Interactions with Potent Antitumor Activity In Vivo

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Identification of a short ACE2-derived stapled peptide targeting the SARS-CoV-2 spike protein

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Advances in the development of Wnt/β-catenin signaling inhibitors

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Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions

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Zooming in on the WNT/CTNNB1 Destruction Complex: Functional Mechanistic Details with Implications for Therapeutic Targeting

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Structure‐Based Design of Bicyclic Helical Peptides That Target the Oncogene β‐Catenin

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Rational Design of a Dual-Targeting Natural Toxin-Like Bicyclic Peptide for Selective Bioenergetic Blockage in Cancer Cells

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Glucuronic acid as a helix-inducing linker in short peptides

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HBx-Derived Constrained Peptides Inhibit the Secretion of Hepatitis B Virus Antigens

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Cell-Permeable Peptide Inhibitors of the p53-hDM2 Interaction via Foldamer Helix Mimicry and Bis-Thioether Stapling

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Programmable short peptides for modulating stem cell fate in tissue engineering and regenerative medicine

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Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

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Membrane-Active Peptides Attack Cell Membranes in a Lipid-Regulated Curvature-Generating Mode

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A new biology of cell penetrating peptides

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Synthesis and biological evaluation of novel all-hydrocarbon cross-linked aza-stapled peptides

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Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness

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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

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Identification of the Stapled α-Helical Peptide ATSP-7041 as a Substrate and Strong Inhibitor of OATP1B1 In Vitro

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Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein–Protein Interactions on a Cell-Penetrating Peptide Scaffold

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Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

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Patent Landscape Highlighting double-edged Scaffold of a WNT5A-agonizing peptide, Foxy5

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Integrative Peptide Drug Development: Chemical Engineering, AI-Driven Design, and Cell-Penetrating Peptides

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Ketohexokinase-A deficiency attenuates the proliferation via reducing β-catenin in gastric cancer cells

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Nanoparticle-mediated delivery of peptide-based degraders enables targeted protein degradationPreprint

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Structure‐Based Design of Bicyclic Helical Peptides That Target the Oncogene β‐Catenin

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Thrombopoietin receptor‐based protein–protein interaction screening (THROPPIS)

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Cell Penetrability of a γ-Crystallin Peptide Fragment from the Discarded Cataractous Eye Emulsion

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Dissecting the geometric and hydrophobic constraints of stapled peptides

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Towards Cell-Permeable Hepatitis B Virus Core Protein Variants as Potential Antiviral Agents

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Guanidinium‐Stapled Helical Peptides for Targeting Protein‐Protein Interactions

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Zellgängige Peptide zur Inhibition des Wnt/β-Catenin Signalweges

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Development of peptide-based inhibitors against β-catenin using in silico approach

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Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein–Protein Interactions on a Cell-Penetrating Peptide Scaffold

Nagano, Y., Arafiles, J. V. V., Kuwata, K., Kawaguchi, Y., Imanishi, M., Hirose, H., & Futaki, S. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00671 · Cited by 5 · see citing works