Comparative Effectiveness of Weight-Loss Interventions in Clinical Practice

Appel, Lawrence J.; Clark, Jeanne M.; Yeh, Hsin-Chieh; Wang, Nae-Yuh; Coughlin, Janelle W.; Daumit, Gail; Miller, Edgar R.; Dalcin, Arlene; Jerome, Gerald J.; Geller, Steven; Noronha, Gary; Pozefsky, Thomas; Charleston, Jeanne; Reynolds, Jeffrey B.; Durkin, Nowella; Rubin, Richard R.; Louis, Thomas A.; Brancati, Frederick L.

doi:10.1056/nejmoa1108660

Cited by 783Obesity and Health PracticesObesity, Physical Activity, DietMobile Health and mHealth Applications

Comparative Effectiveness of Weight-Loss Interventions in Clinical Practice

Open access

Appel, Lawrence J., Clark, Jeanne M., Yeh, Hsin-Chieh, Wang, Nae-Yuh, Coughlin, Janelle W., Daumit, Gail, Miller, Edgar R., Dalcin, Arlene +10 more·2011·New England Journal of Medicine

DOI 10.1056/nejmoa1108660PMC PMC4074540

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Obesity and its cardiovascular complications are extremely common medical problems, but evidence on how to accomplish weight loss in clinical practice is sparse. METHODS: We conducted a randomized, controlled trial to examine the effects of two behavioral weight-loss interventions in 415 obese patients with at least one cardiovascular risk factor. Participants were recruited from six primary care practices; 63.6% were women, 41.0% were black, and the mean age was 54.0 years. One intervention provided patients with weight-loss support remotely--through the telephone, a study-specific Web site, and e-mail. The other intervention provided in-person support during group and individual sessions, along with the three remote means of support. There was also a control group in which weight loss was self-directed. Outcomes were compared between each intervention group and the control group and between the two intervention groups. For both interventions, primary care providers reinforced participation at routinely scheduled visits. The trial duration was 24 months. RESULTS: At baseline, the mean body-mass index (the weight in kilograms divided by the square of the height in meters) for all participants was 36.6, and the mean weight was 103.8 kg. At 24 months, the mean change in weight from baseline was -0.8 kg in the control group, -4.6 kg in the group receiving remote support only (P<0.001 for the comparison with the control group), and -5.1 kg in the group receiving in-person support (P<0.001 for the comparison with the control group). The percentage of participants who lost 5% or more of their initial weight was 18.8% in the control group, 38.2% in the group receiving remote support only, and 41.4% in the group receiving in-person support. The change in weight from baseline did not differ significantly between the two intervention groups. CONCLUSIONS: In two behavioral interventions, one delivered with in-person support and the other delivered remotely, without face-to-face contact between participants and weight-loss coaches, obese patients achieved and sustained clinically significant weight loss over a period of 24 months. (Funded by the National Heart, Lung, and Blood Institute and others; ClinicalTrials.gov number, NCT00783315.).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1056/nejmoa1108660

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In that 2011 U.S. RCT, the percentages of participants who lost 5% or more of their weight in the two interventions were 38.2% and 41.4%, versus 18.8% in the control group.
“The percentages of participants who lost 5% or more of their weight in the two respective interventions were 38.2% and 41.4%, versus only 18.8% in the control group.”
From The Empirical Foundations of Telemedicine Interventions in Primary Care (2016) · cites this paper as [120]
In a 2011 U.S. RCT, after 24 months, weight losses in the two intervention groups (remote support and remote support plus in-person support) were 4.6 kg and 5.1 kg, respectively, whereas weight loss in the control group was 0.8 kg.
“After 24 months, weight losses in the two intervention groups-support by the three media and support by the three media plus in-person support-were 4.6 kg and 5.1 kg, respectively, whereas weight loss in the control group was 0.8 kg.”
From The Empirical Foundations of Telemedicine Interventions in Primary Care (2016) · cites this paper as [120]
The addition of allied health experts to the interprofessional healthcare team either by physical colocation, distance consultation, or engagement in staff training can help to achieve higher-quality, more cost-effective care.
“The addition of these experts to the interprofessional healthcare team either by physical colocation, distance consultation, or engagement in staff training can help to achieve higher-quality, more cost-effective care.57–63”
From Better Population Health Through Behavior Change in Adults: A Call to Action (2013) · cites this paper as [61]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526 · see citing works
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820 · see citing works
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580 · see citing works
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981 · see citing works
Self-citation
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621 · see citing works
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies
Prospective Studies Collaboration (2009) · The Lancet · doi:10.1016/s0140-6736(09)60318-4 · Cited by 4,807 · see citing works
International table of glycemic index and glycemic load values: 2002,
Foster-Powell, K., Holt, S. H., & Brand-Miller, J. C. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.5 · Cited by 3,080 · see citing works
Mediterranean Diet, Traditional Risk Factors, and the Rate of Cardiovascular Complications After Myocardial Infarction: Final Report of the Lyon Diet Heart Study
de Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910 · see citing works
Excess Deaths Associated With Underweight, Overweight, and Obesity
Flegal, K. M. (2005) · JAMA · doi:10.1001/jama.293.15.1861 · Cited by 2,834 · see citing works
The Diabetes Prevention Program (DPP)
The Diabetes Prevention Program (DPP) Research Group (2002) · Diabetes Care · doi:10.2337/diacare.25.12.2165 · Cited by 1,938 · see citing works
Cholesterol-lowering effects of dietary fiber: a meta-analysis
Brown, L., Rosner, B., Willett, W. W., & Sacks, F. M. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.1.30 · Cited by 1,857 · see citing works
Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
Selvin, E., Steffes, M. W., Zhu, H., Matsushita, K., Wagenknecht, L., Pankow, J., Coresh, J., & Brancati, F. L. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908359 · Cited by 1,544 · see citing works
Self-citation
Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials
Mensink, R. P., & Katan, M. B. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.8.911 · Cited by 1,477 · see citing works
Influence of Weight Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Neter, J. E., Stam, B. E., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M. (2003) · Hypertension · doi:10.1161/01.hyp.0000094221.86888.ae · Cited by 1,391 · see citing works
Effects of Comprehensive Lifestyle Modification on Blood Pressure Control: Main Results of the PREMIER Clinical Trial
(2003) · JAMA · doi:10.1001/jama.289.16.2083 · Cited by 1,331 · see citing works
Effects of Protein, Monounsaturated Fat, and Carbohydrate Intake on Blood Pressure and Serum Lipids: Results of the OmniHeart Randomized Trial
Appel, L. J., Sacks, F. M., Carey, V. J., Obarzanek, E., Swain, J. F., Miller, E. R., Conlin, P. R., Erlinger, T. P., Rosner, B. A., Laranjo, N. M., et al. (2005) · JAMA · doi:10.1001/jama.294.19.2455 · Cited by 1,170 · see citing works
Self-citation
The glycemic index: methodology and clinical implications
Wolever, T., Jenkins, D., Jenkins, A., & Josse, R. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.5.846 · Cited by 1,168 · see citing works
Long-term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus: Four-Year Results of the Look AHEAD Trial
(2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.334 · Cited by 1,162 · see citing works
National Medical Spending Attributable To Overweight And Obesity: How Much, And Who's Paying?: Further evidence that overweight and obesity are contributing to the nation's health care bill at a growing rate.
Finkelstein, E. A., Fiebelkorn, I. C., & Wang, G. (2003) · Health Affairs · doi:10.1377/hlthaff.w3.219 · Cited by 1,135 · see citing works
Long-Term Weight Loss and Changes in Blood Pressure: Results of the Trials of Hypertension Prevention, Phase II
Stevens, V. J., Obarzanek, E., Cook, N. R., Lee, I.-M., Appel, L. J., Smith West, D., Milas, N. C., Mattfeldt-Beman, M., Belden, L., Bragg, C., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-1-200101020-00007 · Cited by 886 · see citing works
Self-citation
15 Design and Analysis of Cross-Over Trials
Kenward, M. G., & Jones, B. C. (2007) · Handbook of statistics · doi:10.1016/s0169-7161(07)27015-4 · Cited by 873 · see citing works
Effect of a Low–Glycemic Index or a High–Cereal Fiber Diet on Type 2 Diabetes: A Randomized Trial
Jenkins, D. J. A., Kendall, C. W. C., McKeown-Eyssen, G., Josse, R. G., Silverberg, J., Booth, G. L., Vidgen, E., Josse, A. R., Nguyen, T. H., Corrigan, S., et al. (2008) · JAMA · doi:10.1001/jama.2008.808 · Cited by 718 · see citing works
Changes in Plasma Lipids and Lipoproteins in Overweight Men during Weight Loss through Dieting as Compared with Exercise
Wood, P. D., Stefanick, M. L., Dreon, D. M., Frey-Hewitt, B., Garay, S. C., Williams, P. T., Superko, H. R., Fortmann, S. P., Albers, J. J., Vranizan, K. M., et al. (1988) · New England Journal of Medicine · doi:10.1056/nejm198811033191801 · Cited by 675 · see citing works
Effects of Weight Loss and Sodium Reduction Intervention on Blood Pressure and Hypertension Incidence in Overweight People With High-Normal Blood Pressure: The Trials of Hypertension Prevention, Phase II
(1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440270105009 · Cited by 646 · see citing works
Effects on blood lipids of a blood pressure–lowering diet: the Dietary Approaches to Stop Hypertension (DASH) Trial
Obarzanek, E., Sacks, F. M., Vollmer, W. M., Bray, G. A., Miller, E. R., Lin, P.-H., Karanja, N. M., Most-Windhauser, M. M., Moore, T. J., Swain, J. F., et al. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.1.80 · Cited by 598 · see citing works
Self-citation
Effects of Comprehensive Lifestyle Modification on Diet, Weight, Physical Fitness, and Blood Pressure Control: 18-Month Results of a Randomized Trial
Elmer, P. J., Obarzanek, E., Vollmer, W. M., Simons-Morton, D., Stevens, V. J., Young, D. R., Lin, P.-H., Champagne, C., Harsha, D. W., Svetkey, L. P., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-7-200604040-00007 · Cited by 596 · see citing works
Self-citation
Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients.
Järvi, A. E., Karlström, B. E., Granfeldt, Y. E., Björck, I. E., Asp, N. G., & Vessby, B. O. (1999) · Diabetes Care · doi:10.2337/diacare.22.1.10 · Cited by 484 · see citing works
Glycemic response and health—a systematic review and meta-analysis: relations between dietary glycemic properties and health outcomes
Livesey, G., Taylor, R., Hulshof, T., & Howlett, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.258s · Cited by 439 · see citing works
Effects of Dietary Composition on Energy Expenditure During Weight-Loss Maintenance
Ebbeling, C. B., Swain, J. F., Feldman, H. A., Wong, W. W., Hachey, D. L., Garcia-Lago, E., & Ludwig, D. S. (2012) · JAMA · doi:10.1001/jama.2012.6607 · Cited by 431 · see citing works
A randomized trial comparing human E-mail counseling, computer-automated tailored counseling, and no counseling in an Internet weight loss program
Tate, D. F., Jackvony, E. H., & Wing, R. R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.15.1620 · Cited by 427 · see citing works
Screening for Obesity in Adults: Recommendations and Rationale
U.S. Preventive Services Task Force* (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-11-200312020-00012 · Cited by 347 · see citing works
Comparison of 4 Diets of Varying Glycemic Load on Weight Loss and Cardiovascular Risk Reduction in Overweight and Obese Young Adults: A Randomized Controlled Trial
McMillan-Price, J., Petocz, P., Atkinson, F., O’Neill, K., Samman, S., Steinbeck, K., Caterson, I., & Brand-Miller, J. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.14.1466 · Cited by 335 · see citing works
The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein
Wolever, T. M., Gibbs, A. L., Mehling, C., Chiasson, J.-L., Connelly, P. W., Josse, R. G., Leiter, L. A., Maheux, P., Rabasa-Lhoret, R., Rodger, N. W., et al. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.114 · Cited by 333 · see citing works
Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure. The Trials of Hypertension Prevention, phase II. The Trials of Hypertension Prevention Collaborative Research Group
(1997) · Archives of Internal Medicine · doi:10.1001/archinte.157.6.657 · Cited by 317 · see citing works
No difference in body weight decrease between a low-glycemic-index and a high-glycemic-index diet but reduced LDL cholesterol after 10-wk ad libitum intake of the low-glycemic-index diet
Sloth, B., Krog-Mikkelsen, I., Flint, A., Tetens, I., Björck, I., Vinoy, S., Elmståhl, H. L., Astrup, A. V., Lang, V., & Raben, A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.337 · Cited by 273 · see citing works
The use of low-glycaemic index diets in diabetes control
Thomas, D. E., & Elliott, E. J. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510001534 · Cited by 225 · see citing works
Treatment of Obesity in Primary Care Practice in the United States: A Systematic Review
Tsai, A. G., & Wadden, T. A. (2009) · Journal of General Internal Medicine · doi:10.1007/s11606-009-1042-5 · Cited by 223 · see citing works
Evaluation of the overall efficacy of the Omron office digital blood pressure HEM-907 monitor in adults
White, W. B., & Anwar, Y. A. (2001) · Blood Pressure Monitoring · doi:10.1097/00126097-200104000-00007 · Cited by 213 · see citing works
Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial
Jebb, S. A., Lovegrove, J. A., Griffin, B. A., Frost, G. S., Moore, C. S., Chatfield, M. D., Bluck, L. J., Williams, C. M., & Sanders, T. A. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.29096 · Cited by 192 · see citing works
Effects of Weight Loss and Long-Term Weight Maintenance With Diets Varying in Protein and Glycemic Index on Cardiovascular Risk Factors: The Diet, Obesity, and Genes (DiOGenes) Study: A Randomized, Controlled Trial
Gögebakan, Ö., Kohl, A., Osterhoff, M. A., van Baak, M. A., Jebb, S. A., Papadaki, A., Martinez, J. A., Handjieva-Darlenska, T., Hlavaty, P., Weickert, M. O., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.033274 · Cited by 180 · see citing works
Weight Control in the Physician's Office
Ashley, J. M., St Jeor, S. T., Schrage, J. P., Perumean-Chaney, S. E., Gilbertson, M. C., McCall, N. L., & Bovee, V. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.13.1599 · Cited by 163 · see citing works
Associations of Glycemic Index and Load With Coronary Heart Disease Events: A Systematic Review and Meta‐Analysis of Prospective Cohorts
Mirrahimi, A., de Souza, R. J., Chiavaroli, L., Sievenpiper, J. L., Beyene, J., Hanley, A. J., Augustin, L. S. A., Kendall, C. W. C., & Jenkins, D. J. A. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.112.000752 · Cited by 161 · see citing works
Low glycaemic index diets and blood lipids: a systematic review and meta-analysis of randomised controlled trials
Goff, L. M., Cowland, D. E., Hooper, L., & Frost, G. S. (2013) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.06.002 · Cited by 151 · see citing works
Comparison of Methods for Delivering a Lifestyle Modification Program for Obese Patients: A Randomized Trial
Digenio, A. G., Mancuso, J. P., Gerber, R. A., & Dvorak, R. V. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-4-200902170-00006 · Cited by 148 · see citing works
Dietary glycaemic index and glycaemic load in relation to the risk of type 2 diabetes: a meta-analysis of prospective cohort studies
Dong, J.-Y., Zhang, L., Zhang, Y.-H., & Qin, L.-Q. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451100540x · Cited by 124 · see citing works
The Effect of High- and Low-Glycemic Index Energy Restricted Diets on Plasma Lipid and Glucose Profiles in Type 2 Diabetic Subjects with Varying Glycemic Control
Heilbronn, L. K., Noakes, M., & Clifton, P. M. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719204 · Cited by 124 · see citing works
Reduced Glycemic Index and Glycemic Load Diets Do Not Increase the Effects of Energy Restriction on Weight Loss and Insulin Sensitivity in Obese Men and Women
Raatz, S. K., Torkelson, C. J., Redmon, J. B., Reck, K. P., Kwong, C. A., Swanson, J. E., Liu, C., Thomas, W., & Bantle, J. P. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2387 · Cited by 112 · see citing works
An 18-mo randomized trial of a low-glycemic-index diet and weight change in Brazilian women
Sichieri, R., Moura, A. S., Genelhu, V. A., Hu, F. B., & Willett, W. C. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.707 · Cited by 98 · see citing works
Transtheoretical Model‐Chronic Disease Care for Obesity in Primary Care: A Randomized Trial
Logue, E. E., Sutton, K., Jarjoura, D. G., Smucker, W. D., Baughman, K. R., & Capers, C. F. (2005) · Obesity Research · doi:10.1038/oby.2005.106 · Cited by 93 · see citing works
Beneficial effects of a 5-week low-glycaemic index regimen on weight control and cardiovascular risk factors in overweight non-diabetic subjects
de Rougemont, A., Normand, S., Nazare, J., Skilton, M. R., Sothier, M., Vinoy, S., & Laville, M. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507778674 · Cited by 82 · see citing works
Targeting dietary fat or glycemic load in the treatment of obesity and type 2 diabetes: A randomized controlled trial
Fabricatore, A. N., Wadden, T. A., Ebbeling, C. B., Thomas, J. G., Stallings, V. A., Schwartz, S. S., & Ludwig, D. S. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.12.016 · Cited by 75 · see citing works
PREMIER—A Trial of Lifestyle Interventions for Blood Pressure Control: Intervention Design and Rationale
Funk, K. L., Elmer, P. J., Stevens, V. J., Harsha, D. W., Craddick, S. R., Lin, P.-H., Young, D. R., Champagne, C. M., Brantley, P. J., McCarron, P. B., et al. (2008) · Health Promotion Practice · doi:10.1177/1524839906289035 · Cited by 74 · see citing works
Self-citation
Multiple Inferences Using Confidence Intervals
Ludbrook, J. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03223.x · Cited by 74 · see citing works
Effects of low- and high-glycemic index/glycemic load diets on coronary heart disease risk factors in overweight/obese men
Shikany, J. M., Phadke, R. P., Redden, D. T., & Gower, B. A. (2009) · Metabolism · doi:10.1016/j.metabol.2009.06.006 · Cited by 67 · see citing works
Glycemic load effect on fasting and post-prandial serum glucose, insulin, IGF-1 and IGFBP-3 in a randomized, controlled feeding study
Runchey, S. S., Pollak, M. N., Valsta, L. M., Coronado, G. D., Schwarz, Y., Breymeyer, K. L., Wang, C., Wang, C.-Y., Lampe, J. W., & Neuhouser, M. L. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.107 · Cited by 56 · see citing works
Effects of glycemic load on metabolic risk markers in subjects at increased risk of developing metabolic syndrome
Vrolix, R., & Mensink, R. P. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28339 · Cited by 55 · see citing works
Continuous glucose monitoring to assess the ecologic validity of dietary glycemic index and glycemic load
Fabricatore, A. N., Ebbeling, C. B., Wadden, T. A., & Ludwig, D. S. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.020354 · Cited by 51 · see citing works
Kansas Primary Care Weighs In: A Pilot Randomized Trial of a Chronic Care Model Program for Obesity in 3 Rural Kansas Primary Care Practices
Ely, A. C., Banitt, A., Befort, C. A., Hou, Q., Rhode, P. C., Grund, C., Greiner, A. K., Jeffries, S. K., & Ellerbeck, E. F. (2008) · The Journal of Rural Health · doi:10.1111/j.1748-0361.2008.00148.x · Cited by 50 · see citing works
Design considerations and rationale of a multi-center trial to sustain weight loss: the weight loss maintenance trial
Brantley, P. J., Appel, L. J., Hollis, J. F., Stevens, V. J., Ard, J. D., Champagne, C. M., Elmer, P. J., Harsha, D. W., Myers, V. H., Proschan, M. A., et al. (2008) · Clinical Trials · doi:10.1177/1740774508096315 · Cited by 45 · see citing works
Self-citation
Effect of the glycemic index of carbohydrates on day-long (10 h) profiles of plasma glucose, insulin, cholecystokinin and ghrelin
Reynolds, R. C., Stockmann, K. S., Atkinson, F. S., Denyer, G. S., & Brand-Miller, J. C. (2008) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2008.52 · Cited by 44 · see citing works
Tackling Obesity
Kushner, R. F. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.479 · Cited by 42 · see citing works
Recent Advances in Internet-Delivered, Evidence-Based Weight Control Programs for Adults
Krukowski, R. A., West, D. S., & Harvey‐Berino, J. (2009) · Journal of Diabetes Science and Technology · doi:10.1177/193229680900300122 · Cited by 29 · see citing works
Independent but coordinated trials: insights from the Practice-based Opportunities for Weight Reduction Trials Collaborative Research Group
Yeh, H., Clark, J. M., Emmons, K. M., Moore, R. H., Bennett, G. G., Warner, E. T., Sarwer, D. B., Jerome, G. J., Miller, E. R., Volger, S., et al. (2010) · Clinical Trials · doi:10.1177/1740774510374213 · Cited by 29 · see citing works
Self-citation
Treatment of Obesity in Primary Care Practice: The Practice Based Opportunities for Weight Reduction (POWER) Trial at Johns Hopkins
Jerome, G. J., Yeh, H., Dalcin, A., Reynolds, J. B., Gauvey-Kern, M., Charleston, J. B., Durkin, N., & Appel, L. J. (2009) · Obesity and Weight Management · doi:10.1089/obe.2009.0506 · Cited by 11 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292 · see citing works
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., Hu, F. B., Hubbard, V. S., Jakicic, J. M., Kushner, R. F., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.004 · Cited by 4,058 · see citing works
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., Hu, F. B., Hubbard, V. S., Jakicic, J. M., Kushner, R. F., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437739.71477.ee · Cited by 2,735 · see citing works
Mechanisms, Pathophysiology, and Management of Obesity
Heymsfield, S. B., & Wadden, T. A. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1514009 · Cited by 1,867 · see citing works
From ideas to efficacy: The ORBIT model for developing behavioral treatments for chronic diseases
Czajkowski, S. M., Powell, L. H., Adler, N., Naar-King, S., Reynolds, K. D., Hunter, C. M., Laraia, B., Olster, D. H., Perna, F. M., Peterson, J. C., et al. (2015) · Health Psychology · doi:10.1037/hea0000161 · Cited by 1,161 · see citing works
Interactive telemedicine: effects on professional practice and health care outcomes
Flodgren, G., Rachas, A., Farmer, A. J., Inzitari, M., & Shepperd, S. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002098.pub2 · Cited by 806 · see citing works
Effect of Weight Reduction and Cardiometabolic Risk Factor Management on Symptom Burden and Severity in Patients With Atrial Fibrillation: A Randomized Clinical Trial
Abed, H. S., Wittert, G. A., Leong, D. P., Shirazi, M. G., Bahrami, B., Middeldorp, M. E., Lorimer, M. F., Lau, D. H., Antic, N. A., Brooks, A. G., et al. (2013) · JAMA · doi:10.1001/jama.2013.280521 · Cited by 776 · see citing works
A Behavioral Weight-Loss Intervention in Persons with Serious Mental Illness
Daumit, G. L., Dickerson, F. B., Wang, N.-Y., Dalcin, A., Jerome, G. J., Anderson, C. A. M., Young, D. R., Frick, K. D., Yu, A., Gennusa, J. V., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214530 · Cited by 523 · see citing works
Self-citation
Long-Term Adherence to Health Behavior Change
Middleton, K. R., Anton, S. D., & Perri, M. G. (2013) · American Journal of Lifestyle Medicine · doi:10.1177/1559827613488867 · Cited by 499 · see citing works
Behavioral and Pharmacotherapy Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
LeBlanc, E. S., Patnode, C. D., Webber, E. M., Redmond, N., Rushkin, M., & O’Connor, E. A. (2018) · JAMA · doi:10.1001/jama.2018.7777 · Cited by 463 · see citing works
Digital health interventions for the prevention of cardiovascular disease: a systematic review and meta-analysis
Widmer, R. J., Collins, N. M., Collins, C. S., West, C. P., Lerman, L. O., & Lerman, A. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.12.026 · Cited by 416 · see citing works
<scp>eH</scp> ealth interventions for the prevention and treatment of overweight and obesity in adults: a systematic review with meta‐analysis
Hutchesson, M. J., Rollo, M. E., Krukowski, R., Ells, L., Harvey, J., Morgan, P. J., Callister, R., Plotnikoff, R., & Collins, C. E. (2015) · Obesity Reviews · doi:10.1111/obr.12268 · Cited by 380 · see citing works
The Empirical Foundations of Telemedicine Interventions in Primary Care
Bashshur, R. L., Howell, J. D., Krupinski, E. A., Harms, K. M., Bashshur, N., & Doarn, C. R. (2016) · Telemedicine and e-Health · doi:10.1089/tmj.2016.0045 · Cited by 370 · see citing works
Behavioral Counseling to Promote a Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Cardiovascular Disease Risk Factors: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Patnode, C. D., Evans, C. V., Senger, C. A., Redmond, N., & Lin, J. S. (2017) · JAMA · doi:10.1001/jama.2017.3303 · Cited by 380 · see citing works
Integrating Technology Into Standard Weight Loss Treatment: A Randomized Controlled Trial
Spring, B., Duncan, J. M., Janke, E. A., Kozak, A. T., McFadden, H. G., DeMott, A., Pictor, A., Epstein, L. H., Siddique, J., Pellegrini, C. A., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1221 · Cited by 234 · see citing works
Neural responses to visual food cues according to weight status: a systematic review of functional magnetic resonance imaging studies
Pursey, K. M., Stanwell, P., Callister, R. J., Brain, K., Collins, C. E., & Burrows, T. L. (2014) · Frontiers in Nutrition · doi:10.3389/fnut.2014.00007 · Cited by 239 · see citing works
8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: Standards of Care in Diabetes–2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Echouffo-Tcheugui, J. B., Ekhlaspour, L., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s008 · Cited by 236 · see citing works
8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes: <i>Standards of Care in Diabetes–2024</i>
American Diabetes Association Professional Practice Committee, ElSayed, N. A., Aleppo, G., Bannuru, R. R., Bruemmer, D., Collins, B. S., Ekhlaspour, L., Hilliard, M. E., Johnson, E. L., Khunti, K., et al. (2024) · Diabetes Care · doi:10.2337/dc24-s008 · Cited by 213 · see citing works
Better Population Health Through Behavior Change in Adults: A Call to Action
Spring, B., Ockene, J. K., Gidding, S. S., Mozaffarian, D., Moore, S., Rosal, M. C., Brown, M. D., Vafiadis, D. K., Cohen, D. L., Burke, L. E., et al. (2013) · Circulation · doi:10.1161/01.cir.0000435173.25936.e1 · Cited by 195 · see citing works
Telehealth methods to deliver dietary interventions in adults with chronic disease: a systematic review and meta-analysis
Kelly, J. T., Reidlinger, D. P., Hoffmann, T. C., & Campbell, K. L. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136333 · Cited by 162 · see citing works
The Comparative Effectiveness of Diabetes Prevention Strategies to Reduce Postpartum Weight Retention in Women With Gestational Diabetes Mellitus: The Gestational Diabetes’ Effects on Moms (GEM) Cluster Randomized Controlled Trial
Ferrara, A., Hedderson, M. M., Brown, S. D., Albright, C. L., Ehrlich, S. F., Tsai, A.-L., Caan, B. J., Sternfeld, B., Gordon, N. P., Schmittdiel, J. A., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1254 · Cited by 171 · see citing works
Intensive lifestyle intervention for obesity: principles, practices, and results.
Webb, V. L., & Wadden, T. A. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.045 · Cited by 167 · see citing works
Effectiveness of behavioural weight loss interventions delivered in a primary care setting: a systematic review and meta-analysis
Booth, H. P., Prevost, T. A., Wright, A. J., & Gulliford, M. C. (2014) · Family Practice · doi:10.1093/fampra/cmu064 · Cited by 144 · see citing works
Systematic review and meta‐analysis of internet‐delivered interventions providing personalized feedback for weight loss in overweight and obese adults
Sherrington, A., Newham, J. J., Bell, R., Adamson, A., McColl, E., & Araujo‐Soares, V. (2016) · Obesity Reviews · doi:10.1111/obr.12396 · Cited by 138 · see citing works
A brief intervention for weight control based on habit-formation theory delivered through primary care: results from a randomised controlled trial
Beeken, R. J., Leurent, B., Vickerstaff, V, Wilson, R., Croker, H., Morris, S., Omar, R. Z., Nazareth, I., & Wardle, J. (2017) · International Journal of Obesity · doi:10.1038/ijo.2016.206 · Cited by 126 · see citing works
Reduced reward-driven eating accounts for the impact of a mindfulness-based diet and exercise intervention on weight loss: Data from the SHINE randomized controlled trial
Mason, A. E., Epel, E. S., Aschbacher, K., Lustig, R. H., Acree, M., Kristeller, J., Cohn, M., Dallman, M., Moran, P. J., Bacchetti, P., et al. (2016) · Appetite · doi:10.1016/j.appet.2016.02.009 · Cited by 125 · see citing works
Web-Based Interventions Targeting Cardiovascular Risk Factors in Middle-Aged and Older People: A Systematic Review and Meta-Analysis
Beishuizen, C. R., Stephan, B. C., van Gool, W. A., Brayne, C., Peters, R. J., Andrieu, S., Kivipelto, M., Soininen, H., Busschers, W. B., Moll van Charante, E. P., et al. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.5218 · Cited by 128 · see citing works
The development of a mobile monitoring and feedback tool to stimulate physical activity of people with a chronic disease in primary care: a user-centered design
van der Weegen, S., Verwey, R., Spreeuwenberg, M., Tange, H., van der Weijden, T., & de Witte, L. (2013) · JMIR mhealth and uhealth · doi:10.2196/mhealth.2526 · Cited by 128 · see citing works
The Healthy Living Partnerships to Prevent Diabetes Study
Katula, J. A., Vitolins, M. Z., Morgan, T. M., Lawlor, M. S., Blackwell, C. S., Isom, S. P., Pedley, C. F., & Goff, D. C. (2013) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.12.015 · Cited by 127 · see citing works
Intensive Behavioral Therapy for Obesity Combined with Liraglutide 3.0 mg: A Randomized Controlled Trial
Wadden, T. A., Walsh, O. A., Berkowitz, R. I., Chao, A. M., Alamuddin, N., Gruber, K., Leonard, S., Mugler, K., Bakizada, Z., & Tronieri, J. S. (2019) · Obesity · doi:10.1002/oby.22359 · Cited by 116 · see citing works
Understanding weight regain after a nutritional weight loss intervention: systematic review and meta-analysis
Machado, A. M., Guimarães, N. S., Bocardi, V. B., da Silva, T. P. R., Carmo, A. S. D., Menezes, M. C. D., & Duarte, C. K. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.03.020 · Cited by 109 · see citing works
Technology-Assisted Weight Loss Interventions in Primary Care: A Systematic Review
Levine, D. M., Savarimuthu, S., Squires, A., Nicholson, J., & Jay, M. (2015) · Journal of General Internal Medicine · doi:10.1007/s11606-014-2987-6 · Cited by 105 · see citing works
Personalised eHealth interventions in adults with overweight and obesity: A systematic review and meta-analysis of randomised controlled trials
Lau, Y., Chee, D. G. H., Chow, X. P., Cheng, L. J., & Wong, S. N. (2020) · Preventive Medicine · doi:10.1016/j.ypmed.2020.106001 · Cited by 78 · see citing works
Cardiovascular effects of bariatric surgery
Beamish, A. J., Olbers, T., Kelly, A. S., & Inge, T. H. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.162 · Cited by 84 · see citing works
Randomised controlled feasibility trial of a web-based weight management intervention with nurse support for obese patients in primary care
Yardley, L., Ware, L. J., Smith, E. R., Williams, S., Bradbury, K. J., Arden-Close, E. J., Mullee, M. A., Moore, M. V., Peacock, J. L., Lean, M. E., et al. (2014) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-11-67 · Cited by 84 · see citing works
Growing Right Onto Wellness (GROW): A family-centered, community-based obesity prevention randomized controlled trial for preschool child–parent pairs
Po'e, E. K., Heerman, W. J., Mistry, R. S., & Barkin, S. L. (2013) · Contemporary Clinical Trials · doi:10.1016/j.cct.2013.08.013 · Cited by 78 · see citing works
Virtual small groups for weight management: an innovative delivery mechanism for evidence-based lifestyle interventions among obese men
Azar, K. M. J., Aurora, M., Wang, E. J., Muzaffar, A., Pressman, A., & Palaniappan, L. P. (2015) · Translational Behavioral Medicine · doi:10.1007/s13142-014-0296-6 · Cited by 59 · see citing works
2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome
Ndumele, C. E., Rodriguez, F., Dixon, D. L., Khan, S. S., Mukherjee, D., Bajaj, M., Bangalore, S., Bozkurt, B., Breathett, K., Clarke, S. L., et al. (2026) · JACC · doi:10.1016/j.jacc.2026.03.056 · Cited by 90 · see citing works
Pharmacotherapy for Obesity—Trends Using a Population Level National Database
Elangovan, A., Shah, R., & Smith, Z. L. (2021) · Obesity Surgery · doi:10.1007/s11695-020-04987-2 · Cited by 56 · see citing works
Long-Term Effect of Weight Regain Following Behavioral Weight Management Programs on Cardiometabolic Disease Incidence and Risk: Systematic Review and Meta-Analysis
Hartmann-Boyce, J., Theodoulou, A., Oke, J. L., Butler, A. R., Bastounis, A., Dunnigan, A., Byadya, R., Cobiac, L. J., Scarborough, P., Hobbs, F. D. R., et al. (2023) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.122.009348 · Cited by 53 · see citing works
The challenge of a 2-year follow-up after intervention for weight loss in primary care
Holzapfel, C., Cresswell, L., Ahern, A. L., Fuller, N. R., Eberhard, M., Stoll, J., Mander, A. P., Jebb, S. A., Caterson, I. D., & Hauner, H. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.180 · Cited by 51 · see citing works
App-technology to increase physical activity among patients with diabetes type 2 the diacert-study, a randomized controlled trial
Bonn, S. E., Alexandrou, C., Hjörleifsdottir Steiner, K., Wiklander, K., Östenson, C.-G., Löf, M., & Trolle Lagerros, Y. (2018) · BMC Public Health · doi:10.1186/s12889-018-5026-4 · Cited by 48 · see citing works
Web-Based Weight Loss Intervention for Men With Type 2 Diabetes: Pilot Randomized Controlled Trial
Haste, A., Adamson, A. J., McColl, E., Araujo-Soares, V., & Bell, R. (2017) · JMIR Diabetes · doi:10.2196/diabetes.7430 · Cited by 39 · see citing works
The past, present, and future of behavioral obesity treatment
Chao, A. M., Moore, M., & Wadden, T. A. (2025) · International Journal of Obesity · doi:10.1038/s41366-024-01525-3 · Cited by 40 · see citing works
The impact of continued intervention on weight: five-year results from the weight loss maintenance trial
Coughlin, J. W., Brantley, P. J., Champagne, C. M., Vollmer, W. M., Stevens, V. J., Funk, K., Dalcin, A. T., Jerome, G. J., Myers, V. H., Tyson, C., et al. (2016) · Obesity · doi:10.1002/oby.21454 · Cited by 37 · see citing works
Self-citation
Using artificial intelligence to optimize delivery of weight loss treatment: protocol for an efficacy and cost-effectiveness trial
Forman, E. M., Berry, M. P., Butryn, M. L., Hagerman, C. J., Huang, Z., Juarascio, A. S., LaFata, E. M., Ontañón, S., Tilford, J. M., & Zhang, F. (2023) · Contemporary Clinical Trials · doi:10.1016/j.cct.2022.107029 · Cited by 24 · see citing works
Reducing depression during the menopausal transition with health coaching: Results from the healthy menopausal transition randomised controlled trial
Almeida, O. P., Marsh, K., Murray, K., Hickey, M., Sim, M., Ford, A., & Flicker, L. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.07.012 · Cited by 21 · see citing works
Dietary adherence and program attrition during a severely energy-restricted diet among people with complex class III obesity: A qualitative exploration
Maston, G., Franklin, J., Hocking, S., Swinbourne, J., Gibson, A., Manson, E., Sainsbury, A., & Markovic, T. (2021) · PLOS ONE · doi:10.1371/journal.pone.0253127 · Cited by 14 · see citing works
The effects of contemporary behavioural weight loss maintenance interventions for long term weight loss: A systematic review
Gilmartin, J., & Murphy, M. (2015) · Journal of Research in Nursing · doi:10.1177/1744987115599671 · Cited by 11 · see citing works
Effect of survodutide, a glucagon and GLP-1 receptor dual agonist, on weight loss: a meta-analysis of randomized controlled trials
Wan, H., Xu, N., Wang, L., Liu, Y., Fatahi, S., Sohouli, M. H., & Guimarães, N. S. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01501-x · Cited by 8 · see citing works
Clinical interventions to break the obesity and cancer link: a narrative review
Bhardwaj, N. J., Chae, K., Sheng, J. Y., & Yeh, H.-C. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10055-1 · Cited by 5 · see citing works
Self-citation

Authors: Appel, L. J., Clark, J. M., Yeh, H.-C., Wang, N.-Y., Coughlin, J. W., Daumit, G., Miller, E. R., Dalcin, A., Jerome, G. J., Geller, S., Noronha, G., Pozefsky, T., Charleston, J., Reynolds, J. B., Durkin, N., Rubin, R. R., Louis, T. A., & Brancati, F. L.
Affiliations: Johns Hopkins University (US)
Centennial Medical Group (US)
ORCID: Appel, Lawrence J.
Clark, Jeanne M.
Yeh, Hsin-Chieh
Wang, Nae-Yuh
Coughlin, Janelle W.
Daumit, Gail
Miller, Edgar R.
Dalcin, Arlene
Jerome, Gerald J.
Geller, Steven
Charleston, Jeanne
Durkin, Nowella
Louis, Thomas A.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2011-11-24
Volume: 365
Issue: 21
Pages: 1959-1968
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmoa1108660
PMC: PMC4074540
OpenAlex: W2113892656
Semantic Scholar: 574a317645440e815416d39f009c5723e5be2352
Cited by: 783
References: 65
Citations by year: 2026: 15 · 2025: 29 · 2024: 39 · 2023: 24 · 2022: 39 · 2021: 50 · 2020: 51 · 2019: 52 · 2018: 57 · 2017: 44 · 2016: 71 · 2015: 74 · 2014: 65 · 2013: 100 · 2012: 68
FWCI: 177.78
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5p60dk079637-02)
National Heart, Lung, and Blood Institute (U01HL087085, HL087085)
National Institute of Diabetes and Digestive and Kidney Diseases (P60 DK-079637, P30DK079637)
National Center for Research Resources (UL1RR025005)
Topics: Health Sciences › Health Professions › Pharmacy › Obesity and Health Practices
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
Keywords: obesity, weight loss, behavioral weight loss, primary care, cardiovascular risk factors, weight loss maintenance
MeSH terms: Behavior Therapy, Cardiovascular Diseases, Counseling, Diet, Reducing, Female, Humans, Male, Middle Aged, Obesity, Risk Factors, Weight Loss, Health Behavior, Exercise, Telemedicine, Physicians, Primary Care

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Comparative Effectiveness of Weight-Loss Interventions in Clinical Practice

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks