The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
The interaction network of the chaperonin CCT
Open accessAbstract
The eukaryotic cytosolic chaperonin containing TCP-1 (CCT) has an important function in maintaining cellular homoeostasis by assisting the folding of many proteins, including the cytoskeletal components actin and tubulin. Yet the nature of the proteins and cellular pathways dependent on CCT function has not been established globally. Here, we use proteomic and genomic approaches to define CCT interaction networks involving 136 proteins/genes that include links to the nuclear pore complex, chromatin remodelling, and protein degradation. Our study also identifies a third eukaryotic cytoskeletal system connected with CCT: the septin ring complex, which is essential for cytokinesis. CCT interactions with septins are ATP dependent, and disrupting the function of the chaperonin in yeast leads to loss of CCT-septin interaction and aberrant septin ring assembly. Our results therefore provide a rich framework for understanding the function of CCT in several essential cellular processes, including epigenetics and cell division.
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“in S. cerevisiae all five septin subunits physically interact with the CCT complex”
From Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans (2018) · cites this paper as Dekker et al., 2008
In the citing paper
“the CCT interaction network includes over 136 genes involved in the nuclear pore complex, chromatin remodeling, and protein degradation in S. cerevisiae (Dekker et al., 2008”
From Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans (2018) · cites this paper as Dekker et al., 2008
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Cites
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Research works printed but not linked: 1
- Amberg DC, Burke DJ, Strathern JN (2005) Methods in Yeast Genetics. Cold Spring Harbour, New York, USA: Cold Spring Harbour Laboratory Press
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The molecular chaperone CCT: Functions beyond folding
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Metadata
- Authors
- Dekker, C., Stirling, P. C., McCormack, E. A., Filmore, H., Paul, A., Brost, R. L., Costanzo, M., Boone, C., Leroux, M. R., & Willison, K. R.
- Affiliations
- Institute of Cancer Research (GB)
- Simon Fraser University (CA)
- University of Toronto (CA)
- Venue
- The EMBO Journal
- Published
- 2008-05-29
- Volume
- 27
- Issue
- 13
- Pages
- 1827-1839
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC2486426
- OpenAlex
- W2039639602
- Cited by
- 220
- References
- 59
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 10 · 2023: 2 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 12 · 2018: 18 · 2017: 13 · 2016: 10 · 2015: 15 · 2014: 10 · 2013: 13 · 2012: 15
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Genome Canada
- Michael Smith Health Research BC
- Cancer Research UK
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- chaperonin CCT, TCP1, protein folding, protein-protein interaction network, nuclear pore complex, chromatin remodeling, protein degradation, septins, cytokinesis, actin folding, tubulin folding, epigenetics, cell division, yeast
- MeSH terms
- Saccharomyces cerevisiae, Chaperonins, Genomics, Saccharomyces cerevisiae Proteins, Proteomics, Multiprotein Complexes, Cytokinesis, Chaperonin Containing TCP-1
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