Costanzo, Michael

The Genetic Landscape of a Cell

Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 2,162

A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, M., VanderSluis, B., Koch, E. N., Baryshnikova, A., Pons, C., Tan, G., Wang, W., Usaj, M., Hanchard, J., Lee, S. D., et al. (2016) · Science

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 1,240

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

Hart, T., Tong, A. H. Y., Chan, K., Van Leeuwen, J., Seetharaman, A., Aregger, M., Chandrashekhar, M., Hustedt, N., Seth, S., Noonan, A., et al. (2017) · G3 Genes|Genomes|Genetics

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 599

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

Yang, X., Coulombe-Huntington, J., Kang, S., Sheynkman, G. M., Hao, T., Richardson, A., Sun, S., Yang, F., Shen, Y. A., Murray, R. R., et al. (2016) · Cell

RNA Research and SplicingBioinformatics and Genomic Networks

Cited by 583

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

Baryshnikova, A., Costanzo, M., Kim, Y., Ding, H., Koh, J., Toufighi, K., Youn, J.-Y., Ou, J., San Luis, B.-J., Bandyopadhyay, S., et al. (2010) · Nature Methods

Fungal and yeast genetics researchBioinformatics and Genomic Networks

Cited by 364

Global Genetic Networks and the Genotype-to-Phenotype Relationship

Costanzo, M., Kuzmin, E., van Leeuwen, J., Mair, B., Moffat, J., Boone, C., & Andrews, B. (2019) · Cell

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 241

The interaction network of the chaperonin CCT

Dekker, C., Stirling, P. C., McCormack, E. A., Filmore, H., Paul, A., Brost, R. L., Costanzo, M., Boone, C., Leroux, M. R., & Willison, K. R. (2008) · The EMBO Journal

Heat shock proteins researchMicrotubule and mitosis dynamics

Cited by 220

Genetic interactions reveal the evolutionary trajectories of duplicate genes

VanderSluis, B., Bellay, J., Musso, G., Costanzo, M., Papp, B., Vizeacoumar, F. J., Baryshnikova, A., Andrews, B., Boone, C., & Myers, C. L. (2010) · Molecular Systems Biology

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 110

Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell

Magtanong, L., Ho, C. H., Barker, S. L., Jiao, W., Baryshnikova, A., Bahr, S., Smith, A. M., Heisler, L. E., Choy, J. S., Kuzmin, E., et al. (2011) · Nature Biotechnology

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 108

Combining functional genomics and chemical biology to identify targets of bioactive compounds

Ho, C. H., Piotrowski, J., Dixon, S. J., Baryshnikova, A., Costanzo, M., & Boone, C. (2011) · Current Opinion in Chemical Biology

Fungal and yeast genetics researchComputational Drug Discovery Methods

Cited by 78

Conserved rules govern genetic interaction degree across species

Koch, E. N., Costanzo, M., Bellay, J., Deshpande, R., Chatfield-Reed, K., Chua, G., D'Urso, G., Andrews, B. J., Boone, C., & Myers, C. L. (2012) · Genome Biology

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 68

A Comparative Genomic Approach for Identifying Synthetic Lethal Interactions in Human Cancer

Deshpande, R., Asiedu, M. K., Klebig, M., Sutor, S., Kuzmin, E., Nelson, J., Piotrowski, J., Ho Shin, S., Yoshida, M., Costanzo, M., et al. (2013) · Cancer Research

Chromatin Remodeling and CancerCancer Genomics and Diagnostics

Cited by 64

Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs

Mount, H. O., Revie, N. M., Todd, R. T., Anstett, K., Collins, C., Costanzo, M., Boone, C., Robbins, N., Selmecki, A., & Cowen, L. E. (2018) · PLOS Genetics

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 34