The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
TERRA: telomeric repeat‐containing RNA
Open accessAbstract
Telomeres, the physical ends of eukaryotic chromosomes, consist of tandem arrays of short DNA repeats and a large set of specialized proteins. A recent analysis has identified telomeric repeat‐containing RNA (TERRA), a large non‐coding RNA in animals and fungi, which forms an integral component of telomeric heterochromatin. TERRA transcription occurs at most or all chromosome ends and it is regulated by RNA surveillance factors and in response to changes in telomere length. TERRA functions that are emerging suggest important roles in the regulation of telomerase and in orchestrating chromatin remodelling throughout development and cellular differentiation. The accumulation of TERRA at telomeres can also interfere with telomere replication, leading to a sudden loss of telomere tracts. Such a phenotype can be observed upon impairment of the RNA surveillance machinery or in cells from ICF (Immunodeficiency, Centromeric region instability, Facial anomalies) patients, in which TERRA is upregulated because of DNA methylation defects in the subtelomeric region. Thus, TERRA may mediate several crucial functions at the telomeres, a region of the genome that had been considered to be transcriptionally silent.
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Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
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Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802
Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome
Zhao, J., Sun, B. K., Erwin, J. A., Song, J.-J., & Lee, J. T. (2008) · Science · doi:10.1126/science.1163045 · Cited by 1,579
Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends
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Self-citationSIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · cited 1×
“Abnormal telomeric chromatin states have been linked to severe stochastic telomere sequence loss phenotypes, suggesting crucial roles of this structure during telomere replication (Michishita et al, 2008; Yehezkel et al, 2008).”
BackgroundTelomere end-replication problem and cell aging
Levy, M. Z., Allsopp, R. C., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90096-3 · Cited by 1,069
A mutant with a defect in telomere elongation leads to senescence in yeast
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Cited by
Telomeres and telomerase: three decades of progress
Shay, J. W., & Wright, W. E. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0099-1 · Cited by 924
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Volatile evolution of long noncoding RNA repertoires: mechanisms and biological implications
Kapusta, A., & Feschotte, C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.08.004 · Cited by 295
Telomerase: Structure, functions, and activity regulation
Zvereva, M. I., Shcherbakova, D. M., & Dontsova, O. A. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910130055 · Cited by 165
Telomerase efficiently elongates highly transcribing telomeres in human cancer cells
Farnung, B. O., Brun, C. M., Arora, R., Lorenzi, L. E., & Azzalin, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035714 · Cited by 91
Metadata
- Authors
- Luke, B., & Lingner, J.
- Venue
- The EMBO Journal
- Published
- 2009-07-23
- Volume
- 28
- Issue
- 17
- Pages
- 2503-2510
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2164389045
- Cited by
- 266
- References
- 49
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- green
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